Platelet imipramine binding in patients with panic disorder and major familial depression

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

“…Platelet 5-HT reuptake site binding was found to be decreased in PDA patients in two studies (Iny et al 1994; Lewis et al 1985), while most studies reported no difference comparing to controls (Innis et al 1987; Nutt & Fraser 1987; Pecknold et al 1987; Schneider et al 1987a; Uhde et al 1987; Norman et al 1989a, 1989b; Butler et al 1992;). Moreover, platelet 5-HT concentration was reported also not to change in PDA patients (Balon et al 1987; McIntyre et al 1989), except in one report, where decreased 5-HT concentrations were observed (Evans et al 1985).…”

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

“…HCs [33,34] Platelet aggregation in response to 5-HT ↓ vs. HCs [35] Platelet 5-HT uptake ↓ vs. HCs [23,[35][36][37] =vs. HCs [24,[38][39][40][41][42][43] ↑ vs. HCs [42,44] 5-HIAA CSF levels =vs. HCs [45] ↓ in patients with positive response to TCAs [45] ↑ in MDD females with comorbid PDA vs. patients without comorbid PDA and vs. HCs [46] 5-HIAA jugular venous overflow ↑ vs. HCs [47] Plasma anti-5-HT and 5-HT anti-idiotypic antibodies ↑ vs. HCs [48] Dopaminergic system D plasma level ↑ vs. HCs [49] GH levels in response to apomorphine ↑ vs. MDD [50] HVA CSF concentration =vs.…”

“…Platelet 5-HT uptake was measured in different studies, with inconsistent results. Indeed, four studies reported its decrease in PDA patients compared to the HCs [23,[35][36][37], some studies reported no difference [24,[38][39][40][41][42][43], while others reported an increase [42,44].…”