The Structured Clinical Interview for DSM-III-R (SCID)

Spitzer, Robert L.; Williams, Janet B. W.; Gibbon, Miriam; First, Michael B.

doi:10.1001/archpsyc.1992.01820080032005

Cited by 5,838 publications

(4,553 citation statements)

References 31 publications

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“…Diagnoses were made if the required number of DSM-IV personality symptoms were positive, and at least one of these caused distress, social or occupational dysfunction. Antisocial personality disorder was assessed with questions about conduct disorder before age 15 and adult antisocial symptoms at or after age 15, similar to other standardized interviews 60-64 . Consistent with DSM-IV, we required conduct disorder before age 15 and at least three adult antisocial symptoms for a diagnosis of antisocial personality disorder.…”

Section: Methodsmentioning

confidence: 99%

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Hasin

Fenton

Skodol

et al. 2011

Arch Gen Psychiatry

183

100

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Context Little is known about the role of a broad range of personality disorders in the course of substance use disorder (SUD), and whether these differ by substance. The existing literature focuses mostly on antisocial personality disorder and does not come to clear conclusions. Objective To determine the association between the ten DSM-IV personality disorders and the persistence of common SUDs in a 3-year prospective study of a national sample. Design Data were drawn from participants in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) who had alcohol dependence (N=1,172), cannabis use disorder (N=454) or nicotine dependence (N=4,017) at baseline and who were re-interviewed three years later. Control variables included demographic characteristics, family history of substance disorders, baseline Axis I disorders and treatment status, and prior SUD duration. Main outcome measure Persistent SUD, defined as meeting full criteria for the relevant SUD throughout the 3-year follow-up period. Results Persistent SUD was found among 30.1% of participants with alcohol dependence, 30.8% with cannabis use disorder, and 56.6% with nicotine dependence at baseline. Axis I disorders did not have strong or consistent associations with persistent SUD. In contrast, antisocial personality disorder was significantly associated with persistent alcohol, cannabis and nicotine use disorders (adjusted odds ratios: 2.46-3.51), as was borderline personality disorder (adjusted odds ratios: 2.04-2.78) and schizotypal personality disorder (adjusted odds ratios: 1.65-5.90). Narcissistic, schizoid, and obsessive-compulsive personality disorders were less consistently associated with SUD persistence. Conclusions The consistent findings on the association of antisocial, borderline and schizotypal personality disorders with persistent SUD indicates the importance of these personality disorders in understanding the course of SUD. Future studies should examine dimensional representations of personality disorders and the role of specific components of these disorders, biological and environmental contributors to these relationships, and potential applications of these findings to treatment development.

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Section: Methodsmentioning

confidence: 99%

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Hasin

Fenton

Skodol

et al. 2011

Arch Gen Psychiatry

183

100

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“…All subjects were interviewed by two senior psychiatrists using The Structured Clinical Interview for DSM-III-R (SCID) 33 and were diagnosed using DSM-III-R criteria. The AD and alcohol abuse subjects were all male criminal offenders undergoing forensic psychiatric evaluation as inpatients in the Department of Psychiatry, University of Helsinki.…”

Section: Subjectsmentioning

confidence: 99%

Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence

Anderson

Neyer

et al. 2007

Pharmacogenomics J

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To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5 0 region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at Pp0.01 corrected for multiple testing), whereas a common 18 locus haplotype within the largest LD block of NTRK2, a 119-kb region containing the 5 0 flanking region and exons 1-15, was marginally overrepresented in control subjects compared to AD individuals (global P ¼ 0.057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD.

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“…All subjects received a medical evaluation including medical history and physical examination, laboratory tests (hematology, serum chemistry profile, liver and thyroid studies, urinalysis, urine toxicology, VDRL, urine pregnancy test (for females), and EKG. Diagnosis was confirmed by interview with a research psychiatrist, a structured psychiatric interview for DSM-III-RP (Spitzer et al, 1990), chart review and by contact with an informant and primary clinician. Alcohol consumption history over the preceding 3 months was determined using a validated calendar completion technique (Sobell et al, 1992).…”

Section: Subjects and Screeningmentioning

confidence: 99%

Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia

D’Souza

Gil

Madonick

et al. 2006

Neuropsychopharmacol

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The purpose of this study was to determine whether schizophrenia was associated with alterations in alcohol response that might explain the elevated risk for AUDs in this population. In a randomized, double-blind, placebo-controlled, counter-balanced 3 test day laboratory study, the effects of alcohol were compared in 23 subjects with schizophrenia (without any previous alcohol use disorder (AUD) but with some alcohol exposure) and in 14 healthy subjects matched for age, gender, education, and lifetime exposure to alcohol. Standard alcohol drinks in a scheduled design were administered to produce blood alcohol levels of 0, 0.02-0.04 mg%, or 0.06-0.08 mg%. Schizophrenia symptoms, perceptual alterations, stimulant and depressant subjective effects of alcohol, and 'high' were measured before alcohol administration and at several post-drug time points. Verbal learning and recall, vigilance and distractibility, and motor function were assessed once per test day. Relative to healthy subjects, subjects with schizophrenia reported greater euphoria and stimulatory effects in response to alcohol. Alcohol produced small transient increases in positive psychotic symptoms and perceptual alterations without affecting negative symptoms. Alcohol also impaired several aspects of immediate and delayed recall, and vigilance, and distractibility. Schizophrenia patients showed increased euphoric and stimulatory responses to alcohol. These exaggerated positive responses to alcohol doses may contribute to the increased risk for AUDs associated with schizophrenia. The absence of 'beneficial' effects of alcohol does not support a self-medication hypothesis of alcohol use in schizophrenia.

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The Structured Clinical Interview for DSM-III-R (SCID)

Cited by 5,838 publications

References 31 publications

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence

Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia

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