Platelet gel in cutaneous radiation dermatitis

Iervolino, Vincenzo; Costanzo, Gaetano Di; Azzaro, Raffaele; Diodato, A.; Macchia, Catia Addolorata Di; Meo, Tommaso; Petruzziello, Arnolfo; Loquercio, Giovanna; Muto, Paolo; Apice, Gaetano; Cacciapuoti, Carmela

doi:10.1007/s00520-012-1635-0

Cited by 11 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Limited data exists on the use of PRP for the treatment of CRI. Iervolino et al reported on the use of autologous platelet gel in the treatment of chronic Common Terminology Criteria for Adverse Events grade 3–4 cutaneous radiation dermatitis in patients with extremity sarcoma treated with postoperative radiation therapy . Of the 10 patients enrolled on the study, 7 patients had complete re‐epithelialization of their ulcerations after a median of 5 platelet gel applications.…”

Section: Discussionmentioning

confidence: 99%

Plasma‐based biomaterials for the treatment of cutaneous radiation injury

Miller

Song

Smith

et al. 2018

Wound Repair Regeneration

View full text Add to dashboard Cite

Cutaneous wounds caused by an exposure to high doses of ionizing radiation remain a therapeutic challenge. While new experimental strategies for treatment are being developed, there are currently no off-the-shelf therapies for the treatment of cutaneous radiation injury that have been proven to promote repair of the damaged tissues. Plasmabased biomaterials are biologically active biomaterials made from platelet enriched plasma, which can be made into both solid and semi-solid forms, are inexpensive, and are available as off-the-shelf, nonrefrigerated products. In this study, the use of plasmabased biomaterials for the mitigation of acute and late toxicity for cutaneous radiation injury was investigated using a mouse model. A 2-cm diameter circle of the dorsal skin was irradiated with a single dose of 35 Gy followed by topical treatment with plasmabased biomaterial or vehicle once daily for 5 weeks postirradiation. Weekly imaging demonstrated more complete wound resolution in the plasma-based biomaterial vs. vehicle group which became statistically significant (p < 0.05) at weeks 12, 13, and 14 postmaximum wound area. Despite more complete wound healing, at 9 and 17 weeks postirradiation, there was no statistically significant difference in collagen deposition or skin thickness between the plasma-based biomaterial and vehicle groups based on Masson trichrome staining nor was there a statistically significant difference in inflammatory or fibrosis-related gene expression between the groups. Although significant improvement was not observed for late toxicity, plasma-based biomaterials were effective at promoting wound closure, thus helping to mitigate acute toxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma‐based biomaterials for the treatment of cutaneous radiation injury

Miller

Song

Smith

et al. 2018

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…Although steroids are commonly advocated to treat radiodermatitis, there is a paucity in the literature on the treatment of the condition with these regenerative proteins. Platelet gels, rich in autologous growth factors, have effectively treated chronic cutaneous radiodermatitis, 15 however, administration of growth factors as creams and solutions has not consistently shown efficacy in their healing properties. 16,17 The case of the 49-year-old female nurse, is noteworthy in that her condition of grade 3 radiodermatitis resolved very effectively within 21 days, without pain or discomfort.…”

Section: Discussionmentioning

confidence: 99%

<p>A Fibroblast-Derived Human Growth Factor Preparation for the Management of Acute Radiodermatitis: A Case Report</p>

Vadarli¹,

Angelo-Khattar²

2020

IMCRJ

View full text Add to dashboard Cite

Radiotherapy is a commonly used modality in breast cancer management. Amongst the consequences of treatment are acute and/or chronic skin changes, which often lead to itching, pain, and a diminished aesthetic appearance, all of which greatly impact the patient’s quality of life. Management of radiation-induced skin effects has not as yet been standardized, with various protocols being applied by different radiotherapy departments. This case study outlines the management of a grade 3 acute radiodermatitis in a female with a synergistic preparation of anti-inflammatory cytokines and growth factors derived from human fibroblasts. The treatment resulted in the total resolution of the radiation-induced skin reaction, with a minimally visible residual scar.

show abstract

“…Given the regenerative potential of platelet‐based autologous treatments, future clinical therapeutic applications have already been launched in different directions. Growth factors released after platelet activation may help to regenerate damaged tissue after skin radiation therapy . Minimal invasive new formulations are also being evaluated in order to topically apply autologous proteins with the aim of accelerated wound healing .…”

Section: Future Prospects and Challengesmentioning

confidence: 99%

Opening new horizons in regenerative dermatology using platelet‐based autologous therapies

2017

View full text Add to dashboard Cite

Biological therapeutic therapies are gaining the attention of scientists and medical doctors. Accumulating evidence suggests that blood‐derived autologous therapies are safe and effective treatments for skin repair and wound healing. The fibrin network formed after plasmatic activation and the autologous growth factors released when platelets degranulate constitute a real biological medicine that has been shown to promote cell recruitment, stimulate new blood vessel formation, reduce inflammation as well as protect from local infections. This perspective highlights recent basic and clinical results published on blood‐derived autologous therapies in the field of regenerative dermatology and discusses potential challenges and future prospects.

show abstract

Platelet gel in cutaneous radiation dermatitis

Abstract: Platelet gel treatment could therefore be used to bring about healing in chronic cutaneous radiation dermatitis, lending itself to better patient compliance and a favourable cost/benefit ratio, due to a reduction in the number of medications and hospital visits required.

Cited by 11 publications

References 44 publications

Plasma‐based biomaterials for the treatment of cutaneous radiation injury

Plasma‐based biomaterials for the treatment of cutaneous radiation injury

<p>A Fibroblast-Derived Human Growth Factor Preparation for the Management of Acute Radiodermatitis: A Case Report</p>

Opening new horizons in regenerative dermatology using platelet‐based autologous therapies

Contact Info

Product

Resources

About