Opening new horizons in regenerative dermatology using platelet‐based autologous therapies

Abstract

Biological therapeutic therapies are gaining the attention of scientists and medical doctors. Accumulating evidence suggests that blood‐derived autologous therapies are safe and effective treatments for skin repair and wound healing. The fibrin network formed after plasmatic activation and the autologous growth factors released when platelets degranulate constitute a real biological medicine that has been shown to promote cell recruitment, stimulate new blood vessel formation, reduce inflammation as well as protect from local infections. This perspective highlights recent basic and clinical results published on blood‐derived autologous therapies in the field of regenerative dermatology and discusses potential challenges and future prospects.

Platelet‐derived transforming growth factor‐β1 promotes keratinocyte proliferation in cutaneous wound healing

“…Platelet lysate (PL) or platelet‐rich plasma (PRP) has increasingly been advocated as a novel personalised therapeutic to facilitate tissue repair and regeneration (Anitua, Pino, & Orive, ). PL enhances migration and wound closure of keratinocytes or dermal fibroblasts in vitro (Barsotti et al, ; Ranzato, Mazzucco, Patrone, & Burlando, ).…”

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

“…Platelet‐based autologous therapies have created a new field in regenerative dermatology . There are many products to choose from, when using platelet‐based autologous therapies.…”

Platelet-Rich Fibrin – new course in regenerative medicine and dentistry

“…20 Autologiczne czynniki wzrostu uwalniane podczas degranulacji płytek krwi, stanowią biologiczny lek. 29 Jak wykazano, PRF stymuluje tworzenie nowych naczyń krwionośnych zarówno in vitro, jak i in vivo. Ratajczak i wsp.…”