Platelet distribution width correlates with prognosis of non-small cell lung cancer

Cui, Ming; Li, Na; Liu, Xing; Yun, Zhi Yuan; Niu, Yucun; Zhang, Yong; Gao, Boning; Liu, Tiemin; Wang, Rui Tao

doi:10.1038/s41598-017-03772-z

Cited by 57 publications

(62 citation statements)

References 25 publications

(17 reference statements)

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“…In the multivariate analyses, we illustrated that PDW was an independent prognostic factor. The results of the survival analysis indicated that elevated PDW was associated with better DFS and OS in patients with NSCLC, which was consistent with our initial results . Next, we performed subgroup analyses according to the different TNM stages and different histological subtypes.…”

Section: Discussionsupporting

confidence: 87%

“…In this study, we investigated the prognostic value of PDW in 750 patients with NSCLC. To the best of our knowledge, some researchers have analyzed the prognostic value of preoperative PDW in some solid tumors . However, the clinical significance of preoperative PDW in NSCLC patients is not yet clear.…”

Section: Discussionmentioning

confidence: 99%

“…PDW as a predictive factor has been investigated in many cancers, including NSCLC . To the best of our knowledge, only one study has reported the prognostic value of PDW in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, only one study has reported the prognostic value of PDW in NSCLC. Cui et al . investigated 270 clinical samples and revealed that patients with decreased PDW were associated with poor OS.…”

Section: Discussionmentioning

confidence: 99%

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The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non‐small cell lung cancer

Liu

Zhang

et al. 2020

Thoracic Cancer

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Background The prognostic value of platelet distribution width (PDW) is different in various malignancies. The purpose of this study was to identify the relationship between preoperative PDW and survival in patients with non‐small cell lung cancer (NSCLC). Methods Optimal cutoff values of PDW were confirmed using a receiver operating characteristic (ROC) curve. The Kaplan‐Meier method and log‐rank test were used to estimate disease‐free survival (DFS) and overall survival (OS). Univariate and multivariate Cox regression models were used for prognostic analysis. The likelihood ratio test (LRT) and Akaike information criterion (AIC) were used to compare two models of the TNM staging system and the PDW‐TNM staging system (combination of PDW and the TNM staging system). Results Survival analysis indicated that the disease‐free survival (DFS) and overall survival (OS) of patients with PDW > 12.65 were both significantly longer than those of patients with PDW ≤ 12.65. Multivariate analysis showed that PDW was an independent prognostic factor for DFS and OS. After the two prediction models were established, further LRT analysis showed that the PDW‐TNM model had a better ability to assess patient prognosis. Conclusions PDW might act as an independent risk factor to predict progression and prognosis. Preoperative PDW combined with the TNM staging system showed a better ability to assess the prognosis of NSCLC patients. Key points Our study focused on the prognostic value of preoperative PDW in 750 patients with NSCLC. We also analyzed preoperative PDW in different stages and histological subtypes systematically. A model built by preoperative PDW combined with the TNM staging system had a better prognostic ability. LRT was used to calculate values of the goodness of fit between the model and the TNM staging system.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

“…PDW as a predictive factor has been investigated in many cancers, including NSCLC . To the best of our knowledge, only one study has reported the prognostic value of PDW in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non‐small cell lung cancer

Liu

Zhang

et al. 2020

Thoracic Cancer

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“…An increase P-LCR with increase MPV in stage 0 and 1 indicates that P-LCR may have a similar diagnostic value as MPV [30] in early stage of breast cancer. Since PDW is a measure of platelet volume heterogeneity [33] it goes to show that slightly high PDW value seen in stage 2, 3, and 4 cancer reflects increase heterogeneity in platelet volume and size in these stages of breast cancer in women.…”

Section: Discussionmentioning

confidence: 99%

Association of Platelet Count and Platelet Indices with Stages of Women Breast Cancer in Yola, Nigeria

Etim¹

2018

HTIJ

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Background/Objective: Platelets are involved in mechanisms that promote tumor growth. Platelet indices are marker of platelet activities in cancer. Platelet indices includes: mean platelet volume (MPV), platelet distribution width (PDW), Plateletocrit (PCT), Platelet large cell ratio (P-LCR). This study aims to evaluate platelet count and platelet indices at different stages of women breast cancer in Yola. Materials and Methods:143 women participated in this study. Platelet count and platelet indices were determined using Sysmex XP 300 hematology analyzer.Results: Mean platelet count in women with stage 0/1, 2, and 3/4, was 207±23.09 x 109/l, 113± 14.58 x 109/l and 412±12.50 x 109/l respectively. While mean PDW in women with stage 0/1, 2, and 3/4, breast cancer was 11.9 ±0.21fl, 13.1 ±1.1fl and 12.1 ±0.30fl respectively. MPV of women with stage 0/1, 2, and 3/4, breast cancer was 12.0 ± 1.20fl, 13.9 ± 0.26fl and 14.4 ± 0.08fl respectively. The mean P-LCR of women with stage 0/1 breast cancer was 32.4 ± 0.88% while P-LCR of those with stage 2 and 3/4 breast cancers was 21.8 ± 1.64% and 19.3 ± 1.13% respectively. Mean PCT of women on stage 0/1, 2, 3/4 was 0.23 ± 0.13%, 0.12 ± 1.02% and 0.29 ± 0.20% respectively. Conclusion:Platelet counts and platelet indices vary with stages of breast cancer. Pattern of MPV variations indicates that MPV can be used as indices to measure platelet activation, tumor metastasis/invasion and inflammatory processes in women with breast cancer in Yola Nigeria.

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Clinical application of red cell distribution width, mean platelet volume, and cancer antigen 125 detection in endometrial cancer

Zhang

Liang

et al. 2020

Clinical Laboratory Analysis

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Background Red cell distribution width (RDW) and mean platelet volume (MPV) are considered to be associated with tumors. We investigated the diagnostic value of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, in the diagnosis of endometrial cancer and endometrial hyperplasia. Methods This study included 144 patients with endometrial cancer (stage I: 32; II: 42; III: 48; and IV: 22), 104 patients with endometrial hyperplasia, and 80 healthy control subjects. The whole blood cell parameters were analyzed by a Mindray Blood Cell Analyzer (CAL8000), whereas CA125 was analyzed using an Architect i2000 Analyzer (Abbott). Results Significant differences in RDW, MPV, and CA125 level were observed in the endometrial cancer, endometrial hyperplasia, and control groups ( P < .05). Red cell distribution width was positively correlated ( r = .735) whereas MPV was negatively correlated with ( r = −.736) endometrial cancer staging. The area under the receiver operating characteristic curve of the combined diagnosis of endometrial cancer based on RDW, MPV, and CA125 was 0.924 (95% CI: 0.881‐0.955). The sensitivity and specificity of the combined diagnosis were larger than those of the independent detections involving RDW, MPV, and CA125. Conclusions The combination of RDW, MPV, and CA125 can improve the differential diagnosis of endometrial cancer and endometrial hyperplasia.

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Platelet distribution width correlates with prognosis of non-small cell lung cancer

Cited by 57 publications

References 25 publications

The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non‐small cell lung cancer

The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non‐small cell lung cancer

Association of Platelet Count and Platelet Indices with Stages of Women Breast Cancer in Yola, Nigeria

Clinical application of red cell distribution width, mean platelet volume, and cancer antigen 125 detection in endometrial cancer

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