The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non‐small cell lung cancer

Abstract

Background The prognostic value of platelet distribution width (PDW) is different in various malignancies. The purpose of this study was to identify the relationship between preoperative PDW and survival in patients with non‐small cell lung cancer (NSCLC). Methods Optimal cutoff values of PDW were confirmed using a receiver operating characteristic (ROC) curve. The Kaplan‐Meier method and log‐rank test were used to estimate disease‐free survival (DFS) and overall survival (OS). Univariate and multivariate Cox regression models were used for prognostic analysis. The likelihood ratio test (LRT) and Akaike information criterion (AIC) were used to compare two models of the TNM staging system and the PDW‐TNM staging system (combination of PDW and the TNM staging system). Results Survival analysis indicated that the disease‐free survival (DFS) and overall survival (OS) of patients with PDW > 12.65 were both significantly longer than those of patients with PDW ≤ 12.65. Multivariate analysis showed that PDW was an independent prognostic factor for DFS and OS. After the two prediction models were established, further LRT analysis showed that the PDW‐TNM model had a better ability to assess patient prognosis. Conclusions PDW might act as an independent risk factor to predict progression and prognosis. Preoperative PDW combined with the TNM staging system showed a better ability to assess the prognosis of NSCLC patients. Key points Our study focused on the prognostic value of preoperative PDW in 750 patients with NSCLC. We also analyzed preoperative PDW in different stages and histological subtypes systematically. A model built by preoperative PDW combined with the TNM staging system had a better prognostic ability. LRT was used to calculate values of the goodness of fit between the model and the TNM staging system.

Prognostic Significance of Combined Platelet Distribution Width and C-Reactive Protein Score in Esophageal Cancer

“…By contrast, our findings indicate that low PDWs are related to poor outcomes, which is consistent with several earlier studies (13)(14)(15)(16). Low MPV is reportedly predictive of unfavorable outcomes in diffuse large B-cell lymphoma (29), multiple myeloma (30), and lung cancer (31).…”

The Clinical And Prognostic Value of NLR, PDW, And PNI In Advanced Non-Small-Cell Lung Cancer Treated With Platinum-Based Chemotherapy

“…An increase in platelet number provides a microenvironment that promotes coagulation and aggregation with tumor cells, enabling platelets to guard tumor cells and eventually cause them to escape the host immune system [36]. Our results are inconsistent with those of Liu et al [37], who analyzed 750 postoperative patients with NSCLC and found that low PDW was an independent adverse prognostic factor for DFS and OS. However, discrepancies have been observed in other studies.…”

Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis

“…Nevertheless, the data dealing with these subjects were conflicting among studies. Low PDW has proved to be a strong correlation with poor prognosis in lung ( 28 ), colon ( 29 ), hepatocellular ( 30 ), endometrial ( 31 ), and esophageal cancers ( 32 ), which is consistent with our findings. In the genitourinary tumors, low PDW has shown to be related to more advanced stages in bladder cancer ( 33 ).…”