Platelet-derived nanomotor coated balloon for atherosclerosis combination therapy

Huang, Yangyang; Li, Ting; Gao, Wentao; Wang, Qi; Li, Xiaoyun; Mao, Chun; Zhou, Min; Wan, Mimi; Shen, Jian

doi:10.1039/d0tb00789g

Cited by 62 publications

(63 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, carboxylic groups were activated through EDC-NHS chemistry and conjugated with an antibody. To reduce non-specific binding, the remaining amine reactive-esters of the activated thiol monolayer were blocked with ethanolamine [101] The EDC-NHS coupling was used for the immobilization of VCAM-1 polyclonal antibody on platelet-derived nanomotors [209]. Another approach used modification through thiol terminated PEG linker that allowed for coupling of the targeting moiety antibody [210].…”

Section: Methods Of Immobilization Of Antibodies and Aptamers At The Surface Of Nanomotorsmentioning

confidence: 99%

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

2021

View full text Add to dashboard Cite

Polymer nanoparticles and nano/micromotors are novel nanostructures that are of increased interest especially in the diagnosis and therapy of cancer. These structures are modified by antibodies or nucleic acid aptamers and can recognize the cancer markers at the membrane of the cancer cells or in the intracellular side. They can serve as a cargo for targeted transport of drugs or nucleic acids in chemo- immuno- or gene therapy. The various mechanisms, such as enzyme, ultrasound, magnetic, electrical, or light, served as a driving force for nano/micromotors, allowing their transport into the cells. This review is focused on the recent achievements in the development of polymer nanoparticles and nano/micromotors modified by antibodies and nucleic acid aptamers. The methods of preparation of polymer nanoparticles, their structure and properties are provided together with those for synthesis and the application of nano/micromotors. The various mechanisms of the driving of nano/micromotors such as chemical, light, ultrasound, electric and magnetic fields are explained. The targeting drug delivery is based on the modification of nanostructures by receptors such as nucleic acid aptamers and antibodies. Special focus is therefore on the method of selection aptamers for recognition cancer markers as well as on the comparison of the properties of nucleic acid aptamers and antibodies. The methods of immobilization of aptamers at the nanoparticles and nano/micromotors are provided. Examples of applications of polymer nanoparticles and nano/micromotors in targeted delivery and in controlled drug release are presented. The future perspectives of biomimetic nanostructures in personalized nanomedicine are also discussed.

show abstract

Section: Methods Of Immobilization Of Antibodies and Aptamers At The Surface Of Nanomotorsmentioning

confidence: 99%

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

2021

View full text Add to dashboard Cite

show abstract

“…72 In the treatment of AS, Huang et al synthesized a paclitaxel drug-loaded platelet membrane bionic Janus mesoporous silica porous nanomotors (JAMS) that were obtained by asymmetric modification of platinum (Pt) nanoparticles. 71 After the NIR irradiation, the nanomotors can not only penetrate the plaque and enhance the drug retention efficiency but also realize short-term photothermal elimination of inflammatory macrophages and longterm anti-proliferation effect of the drug (Figure 5C). The introduction of nanomotor, platelet membrane coating and the combination of photothermal and drug therapy provided a new avenue for the treatment of AS with high efficiency.…”

Section: Application Of Mesoporous Silica Nanomaterial-based Drug Delivery System In Atherosclerosismentioning

confidence: 99%

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha¹,

Dai²,

Song³

et al. 2021

IJN

View full text Add to dashboard Cite

Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

show abstract

“…Magnetite is one of the most attractive magnetic inorganic metal-oxides due to its biocompatibility, relatively high magnetic properties, and a wide range of synthetic procedures [91]. The main synthetic procedures include the co-precipitation [92,93], hydro-and solvothermal syntheses [94,95], reduction in template iron oxide with desired shape and size (for example, α-FeOOH, β-FeOOH, α-Fe 2 O 3 ) in wet (polyol reduction [96], hydrazine [97]) and dry reduction [98] (mixed atmosphere of Ar and H 2 ), and thermal decomposition of iron precursors [99].…”

Section: Metal-oxide Particlesmentioning

confidence: 99%

“…Concurrently, it leads to a beneficial decrease in the main pro-atherogenic parameters, for instance, atheroma area reduction by 80%. Direct delivery of paclitaxel-loaded nanocapsules on the surface of the balloon catheter was proposed in [95]. The composition of particles was rather complex, possessing Janus-like behavior ( Table 2).…”

Section: Angiogenesis Preventionmentioning

confidence: 99%

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

et al. 2020

View full text Add to dashboard Cite

Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020.

show abstract

Platelet-derived nanomotor coated balloon for atherosclerosis combination therapy

Abstract:
A nanorobot is used to realize deep penetration of drugs in atherosclerotic plaque, photothermal ablation of inflammatory macrophages and long-term anti-proliferation effects.

Cited by 62 publications

References 49 publications

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Contact Info

Product

Resources

About

Platelet-derived nanomotor coated balloon for atherosclerosis combination therapy

Abstract: A nanorobot is used to realize deep penetration of drugs in atherosclerotic plaque, photothermal ablation of inflammatory macrophages and long-term anti-proliferation effects.

Cited by 62 publications

References 49 publications

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Contact Info

Product

Resources

About

Abstract:
A nanorobot is used to realize deep penetration of drugs in atherosclerotic plaque, photothermal ablation of inflammatory macrophages and long-term anti-proliferation effects.