Platelet-derived growth factor signaling in mesenchymal cells

Abstract

Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs). Their role in enhancing migratory and proliferative responses and extracellular matrix synthesis in these cells, make them key regulators of critical biological functions and in tissue diseases including tissue remodeling, scarring and fibrosis. The activities of the PDGFs have been extensively characterized at the molecular and cellular level and in in vivo model systems. This, in turn, has lead to an increasing number of PDGF-based therapies designed to accelerate or combat defects in tissue repair. This review aims to summarize recent developments in the role of PDGF in key mesenchymal cell functions. Many of the current developments in this field have primarily focused on advancements in understanding cell differentiation, migration, proliferation and the development of emerging PDGF-based therapies and hence will be primary focus of this review.

Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

“…The role of growth factors and cytokines in the fibroblast during wound healing has been discussed in other excellent reviews. [22][23][24][25] Since its manipulation and augmentation is emerging in clinical treatment (including use of acellular dermal matrices and topical wound dressings), the influence of the ECM on the fibroblast, both mechanically and through modulation of molecular pathways, warrants further discussion.…”

Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders

“…Thus it is not a differentiating factor [33]. In receptor turnover, PDGF-BB regulates the recycling of the OPN receptor integrin α V β 3 after internalization back to the cell surface for the formation of focal complexes that are necessary for cell adhesion in osteoblasts [34]. The presence of PDGF-BB potentiates the FGF-2-mediated VEGF expression via the MAP kinase and SAPK/JNK pathways [33].…”

The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation

“…It stimulates the proliferation, migration, differentiation and physiological function of mesenchymal cells [11]. Increasing evidence has indicated that PDGF is an important factor promoting cardiac fibrosis.…”