Platelet adhesiveness, plasma free fatty acids, and serum triglycerides in kwashiorkor

Khalil, Mona; Aref, M. K.; Saifeddine, Mahmoud; Abdel-Malek, A. T.; Guirgis, F. K.; Moghazy, M.; Abdel-Hay, M M

doi:10.1136/adc.49.7.568

Cited by 5 publications

(2 citation statements)

References 8 publications

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“… 39 They were highly vulnerable to infections (despite penicillin prophylaxis), and had persistent oedema. Like children with kwashiorkor, 40 they had markedly increased platelet stickiness. Low-dose aspirin is used to counter this in CNS, but of course if the same mechanism was responsible in kwashiorkor it would correct as the albumin rises with nutritional treatment.…”

Section: The Physiology Of Kwashiorkor Looks a Lot Like Finnish Congementioning

confidence: 96%

Oedema in kwashiorkor is caused by hypoalbuminaemia

Coulthard

2014

Paediatrics and International Child Health

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It has been argued that the oedema of kwashiorkor is not caused by hypoalbuminaemia because the oedema disappears with dietary treatment before the plasma albumin concentration rises. Reanalysis of this evidence and a review of the literature demonstrates that this was a mistaken conclusion and that the oedema is linked to hypoalbuminaemia. This misconception has influenced the recommendations for treating children with severe acute malnutrition. There are close pathophysiological parallels between kwashiorkor and Finnish congenital nephrotic syndrome (CNS) pre-nephrectomy; both develop protein-energy malnutrition and hypoalbuminaemia, which predisposes them to intravascular hypovolaemia with consequent sodium and water retention, and makes them highly vulnerable to develop hypovolaemic shock with diarrhoea. In CNS this is successfully treated with intravenous albumin boluses. By contrast, the WHO advise the cautious administration of hypotonic intravenous fluids in kwashiorkor with shock, which has about a 50% mortality. It is time to trial intravenous bolus albumin for the treatment of children with kwashiorkor and shock.

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Section: The Physiology Of Kwashiorkor Looks a Lot Like Finnish Congementioning

confidence: 96%

Oedema in kwashiorkor is caused by hypoalbuminaemia

Coulthard

2014

Paediatrics and International Child Health

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“…Serum albumin concentration in all these infants was below normal. Coexisting malnutrition may also have played a role in the production of gangrene and is supported by the finding of increased platelet adhesiveness in kwashiorkor (Khalil et al, 1974) and Peripheral gangrene in hypernatraemic dehydration of infancy 619 the fact that blood is hypercoagulable in fasted animals (Antoniades et al, 1973).…”

Section: Discussionmentioning

confidence: 93%

Peripheral gangrene in hypernatraemic dehydration of infancy.

Comay¹,

Karabus²

1975

Archives of Disease in Childhood

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Cystic fibrosis and Helicobacter pylori gastritis, megaloblastic anaemia, subnormal mentality and minor anomalies in two siblings: a new syndrome?

et al. 1991

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Two siblings of consanguineous Arab parents were found to have cystic fibrosis and gastritis associated with Helicobacter pylori, folate deficiency megaloblastic anaemia, subnormal mentality and minor anomalies. The association of H. pylori and megaloblastic anaemia has not been described in patients with cystic fibrosis. H. pylori infection and gastritis is probably more common in patients with cystic fibrosis than appreciated. We believe that the constellation of features in the two sibs represent a possible new autosomal recessive cystic fibrosis-like syndrome.

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Platelet adhesiveness, plasma free fatty acids, and serum triglycerides in kwashiorkor

Cited by 5 publications

References 8 publications

Oedema in kwashiorkor is caused by hypoalbuminaemia

Oedema in kwashiorkor is caused by hypoalbuminaemia

Peripheral gangrene in hypernatraemic dehydration of infancy.

Cystic fibrosis and Helicobacter pylori gastritis, megaloblastic anaemia, subnormal mentality and minor anomalies in two siblings: a new syndrome?

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