Cystic fibrosis and Helicobacter pylori gastritis, megaloblastic anaemia, subnormal mentality and minor anomalies in two siblings: a new syndrome?

Lubani, M. M.; al-Saleh, Q A; Teebi, Ahmad S.; Moosa, A.; Kalaoui, Maher

doi:10.1007/bf01955524

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…Several case reports and a few larger‐scale studies on H. pylori in persons with ID have been published. Lubani et al (1991) described two siblings from Kuwait with developmental disability, cystic fibrosis and H. pylori gastritis. Mauk (1995) described a 6‐year‐old boy from Philadelphia with severe ID, rumination and H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori in people with intellectual disability in a residential care centre in Israel

Morad¹,

Merrick²,

Nasri³

2002

J intellect Disabil Res

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In 1982, Helicobacter pylori (formerly Campylobacter pylori) was identified as a pathogenic factor in peptic ulcer disease by researchers from Australia. Because only a small number of studies of H. pylori infection have been conducted in people with intellectual disability (ID), and none of these were done in Israel, the present authors decided to conduct a pilot study on its prevalence in this population. The Israeli Division for Mental Retardation provides services to over 6000 people in 54 residential care centres (or institutions), and one centre in the south of the country with kibbutz-style living arrangements was selected for this pilot study. The study was performed as part of the yearly routine medical examination of all residents, and blood specimens were drawn for IgG antibodies to H. pylori (ELISA). Out of the 47 individuals screened, 75% (n=36) were seropositive. In addition to the reported high rates of H. pylori infection in residents with ID living in large facilities, the present pilot study suggests that people with ID living in smaller, kibbutz-style arrangements are also at high risk.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori in people with intellectual disability in a residential care centre in Israel

Morad¹,

Merrick²,

Nasri³

2002

J intellect Disabil Res

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“…Lubani et al [11] from Kuwait described two siblings with developmental disability, cystic fibrosis and Helicobacter gastritis; Mauk [12] from Philadelphia described a 6-year-old boy with severe mental retardation, rumination, and several other behavioral disorders. Helicobacter infection was found on examination, treated and clinical improvement found as decreased frequency of rumination and gain of weight.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Persons with Intellectual Disability in Residential Care in Israel

Merrick

Aspler

Dubman

2001

The Scientific World JOURNAL

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Helicobacter pylori (formerly Campylobacter pylori) was identified in 1982 by researchers from Australia as a pathogenic factor in peptic ulcer disease. Due to the few studies on H. pylori infection conducted in the population of persons with intellectual disability it was decided to conduct a clinical study in Israel. The purpose of the study was to determine the occurrence of H. pylori infection in persons who presented with severe dyspeptic symptoms and to monitor clinically the effect of treatment. The Division for Mental Retardation in Israel provides service to 6,022 persons in 53 residential care centers and 1 in central Israel was selected for this pilot study. The study has been performed since 1999 and each patient who came to the medical clinic of the institution with severe dyspeptic symptoms was examined clinically and a blood specimen drawn for IgG antibodies to H. pylori (ELISA, Pharmatop Millenia). In case of positive serology, triple drug treatment (amoxycillin, metronidazole, and pantoprazole or omepra-zole) was initiated for 1 week. Since 1999 a total of 43 persons (total population in care was 224) had severe dyspeptic symptoms and 42 persons (98%, 26 males, 16 females, mean age 45 years, mean institutionalization 20 years) had Helicobacter infection. All patients were treated for 1 week, but six patients received an extra month of omeprazole due to persistent symptoms. At follow-up, clinically all patients had improvement and only seven still had minor complaints (83% treatment success). Persons with developmental disability, intellectual disability, or mental retardation in residential care presenting with severe dyspeptic symptoms had a high incidence of H. pylori infection. Therefore, we recommend serology or urea breath investigations in this population presenting with dyspeptic symptoms and triple drug treatment for 1 week in case of positive findings.

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“…Growth failure and malnutrition are common in children with cerebral palsy, particularly in those with spastic quadriplegia, of which 85% report feeding problems [30,31]. In addition, 20-30% of hemiplegic and diplegic cerebral palsy children are underweight for age [26,32]. There are multifactorial causes: insufficient food intake, feeding problems, increased nutrient losses from vomiting or diarrhea, and alterations in energy requirements in epileptic or metabolic syndromes where increased muscle tone or involuntary movements are seen.…”

Section: Helicobacter Infection and Gastric Neoplasiamentioning

confidence: 99%

“…Good number of studies have been published in persons with intellectual disability, however, large-scale scientific studies have not been published with a population case-control study [22,32,34]. Harris et al [35] (10) reported that hospital residents under 40 years of age had a 87% prevalence of HP compared with 24% for controls, whereas the overall prevalence for all ages was 87% for residents, and 43% for controls in hospital residents with severe learning disabilities.…”

Section: Helicobacter Infection and Gastric Neoplasiamentioning

confidence: 99%

Helicobacter pyloriInfection and Atrophic Corpus Gastritis on Patients with Intellectual Disability: Challenges in the Clinical Translation of Personalized Medicine

Kaipainen¹,

Kaski²

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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The purpose of this chapter is to clarify the prevalence of Helicobacter pylori infection (HPI) and atrophic corpus gastritis (ACG) in patients with intellectual disability (ID) and review the literature surrounding them. We measured the levels of pepsinogen I, pepsinogen II, gastrin-17b (basal), and Helicobacter pylori antibodies from 243 patients with intellectual disability living in Rinnekoti Research Centre at Lakisto area during 2009-2011. We determined the levels of hemoglobin, mean cell volume (MCV), hematocrit, and the mean amount (MCH) and concentration (MCHC) of red cell hemoglobin, the counts of erythrocytes, leucocytes, and thrombocytes. About 43% had high level of Helicobacter pylori antibodies and 6% ACG. Our results show that Helicobacter pylori infection occurs approximately twice the rate it appears in the normal population. Also, the incidence of ACG was higher among patients with ID than normal population. ID may be a risk of getting the Helicobacter pylori infection (HPI) and ACG. In addition, it was found that the level of thrombocytes was increased in HPI group compared to normal group and decreased in ACG group compared to normal group. This study shows that there is clearly a need to investigate (test) more stomach condition in patients with ID.

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Cystic fibrosis and Helicobacter pylori gastritis, megaloblastic anaemia, subnormal mentality and minor anomalies in two siblings: a new syndrome?

Cited by 12 publications

References 19 publications

Prevalence of Helicobacter pylori in people with intellectual disability in a residential care centre in Israel

Prevalence of Helicobacter pylori in people with intellectual disability in a residential care centre in Israel

Helicobacter pylori Infection in Persons with Intellectual Disability in Residential Care in Israel

Helicobacter pyloriInfection and Atrophic Corpus Gastritis on Patients with Intellectual Disability: Challenges in the Clinical Translation of Personalized Medicine

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