Peripheral gangrene in hypernatraemic dehydration of infancy.

Comay, S C; Karabus, C. D.

doi:10.1136/adc.50.8.616

Cited by 17 publications

(5 citation statements)

References 19 publications

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“…(7,12,13,(31)(32)(33)(34) If dehydration persists long enough, the adverse effects are similar to those mediated by acidosis and hypovolemic shock(34). However, we did not find any significant differences between cases and controls.…”

Section: Discussionmentioning

confidence: 99%

Five-Year Neurodevelopmental Outcome of Neonatal Dehydration

Escobar¹,

Liljestrand²,

Hudes³

et al. 2007

The Journal of Pediatrics

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Objective-To determine the long-term outcome of neonatal dehydration.Study design-We identified 182 newborns rehospitalized with dehydration (weight loss ≥12% of birth weight and/or serum sodium ≥150 mEq/L) and 419 randomly selected controls from a cohort of 106,627 term and near-term infants ≥2000 g born from 1995 through 1998 in Northern California Kaiser Permanente hospitals. Outcomes data were obtained from electronic records, interviews, questionnaire responses, and neurodevelopmental evaluations performed in a masked fashion.Results-Follow-up data to the age of at least two years were available for 173/182 children with a history of dehydration (95%) and 372/419 controls (89%) and included formal evaluation at a mean (±SD) age of 5.1±0.12 years for 106 children (58%) and 168 children (40%) respectively. None of the cases developed shock, gangrene, or respiratory failure. Neither crude nor adjusted scores on cognitive tests differed significantly between groups. There was no significant difference between groups in the proportion of children with abnormal neurologic examinations or neurologic diagnoses. Frequencies of parental concerns and reported behavior problems also were not significantly different in the two groups.Conclusions-Neonatal dehydration in this managed care setting was not associated with adverse neurodevelopmental outcomes in infants born at or near term. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In this report, we focus on non-diarrheal neonatal dehydration. We studied a cohort from the Northern California Kaiser Permanente Medical Care Program (KPMCP), a mature managed care organization with integrated information systems. (6,(16)(17)(18)(19)(20) Given the pathophysiology of dehydration, which does not appear to affect any one particular part of the brain, we did not expect to find discrete neurological deficits among our cohort. We expected to find non-specific neurodevelopmental problems affecting multiple domains (i.e., decreases in performance across multiple areas measured). NIH Public Access METHODSThis report covers two of the three cohorts in the Jaundice and Infant Feeding ("JIFee") study, a follow-up study of infants with neonatal jaundice or dehydration and randomly selected controls. We identified subjects born in 1995-96 in previous nested-case-control studies. (6,19,21) Study participants were drawn from 1995-98 KPMCP live births (N=106,627) with birth weights of at least 2000 grams and gestational age of at least 36 weeks (1995-96 cohorts) or 34 weeks (1997-98 cohorts). Eligible subjects had to meet the dehydration d...

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Section: Discussionmentioning

confidence: 99%

Five-Year Neurodevelopmental Outcome of Neonatal Dehydration

Escobar¹,

Liljestrand²,

Hudes³

et al. 2007

The Journal of Pediatrics

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“…It has been postulated that hyper viscosity and poor perfusion seen in hypernatremic dehydration can lead to capillary stasis and damage which in turn can lead to platelet consumption and DIC. Various other authors have also documented this complication [8].…”

Section: Discussionmentioning

confidence: 94%

Peripheral Gangrene in a Breast Fed Neonate—Is Hypernatremic Dehydration the Cause?

et al. 2011

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Hypernatremic dehydration in breast fed neonates is a rare but increasingly recognized problem. If not identified early, it may lead to potentially life threatening complications. The authors describe a neonate who developed thrombosis and lower limb ischemia secondary to hypernatremic dehydration. Peripheral gangrene, as a result of hypernatremic dehydration is extremely uncommon and has rarely been reported before.

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“…Severe dehydration either due to significant fluid loss or fluid deprivation has been identified as one of the risk factors for gangrene in children. 3,10,11 One of the earliest documented evidence that suggested such association in literature was an old report by Comayet al 10 Similarly, Bass and colleagues 11 had reported cases of extremity gangrene complicating diarrheal disease and dehydration. In neonates and young infants on exclusive breastfeeding, occurrence of peripheral gangrene was also linked to hypernatraemic dehydration resulting from inadequate fluid intake.…”

Section: Discussionmentioning

confidence: 99%

Left lower Limb Gangrene Following Diarrhoeal Disease and Dehydration in a child with Transposition of the Great Arteries

Sani¹

2017

jmscr

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Peripheral gangrene in hypernatraemic dehydration of infancy.

Cited by 17 publications

References 19 publications

Five-Year Neurodevelopmental Outcome of Neonatal Dehydration

Five-Year Neurodevelopmental Outcome of Neonatal Dehydration

Peripheral Gangrene in a Breast Fed Neonate—Is Hypernatremic Dehydration the Cause?

Left lower Limb Gangrene Following Diarrhoeal Disease and Dehydration in a child with Transposition of the Great Arteries

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