Plasmonic Janus hybrids for the detection of small metabolites

Abstract

Janus hybrids with amphiphilic structures were used for the sensitive detection of small metabolites.

Nanomaterial based aptasensors for clinical and environmental diagnostic applications

“…12,13 These receptors called aptamers (a term with Latin and Greek origins: aptus meaning t and meros meaning part) have shown notable moldable selectivity for diverse target analytes, ranging from small inorganic molecules, ions, sugars, proteins, and viruses to cells. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Such a varied target range is lacking in antibody generation due to the restriction of target receptor exposure in their native forms. This is more evident in whole cells where the surface antigens contain certain hidden trans-membrane regions, a fact which is generally not accounted for during the maturation of antibodies.…”

Design of plasmonic nanomaterials for diagnostic spectrometry

“…5,8 However, it is difficult to detect biomarkers in real cases owing to the high complexity of biological samples and low abundance of target molecules. 9,10 Currently, nanomaterials with tailored structural characteristics exhibit superior enrichment effects and signal enhancement in molecular diagnostics, which signicantly boost the development of biomarker assays.…”

“…Engineered plasmonic nanomaterials have dened chemophysical properties, and used in a series of state-of-the-art applications with unique mechanisms. 5,10,11 Typically, the design of plasmonic nanomaterials requires consideration of composition, morphology, and surface chemistry. 12,13 With regard to composition, noble metals (e.g., Au and Ag) are the most used candidates for desirable surface plasmons.…”

“…Spectrometry methods display advantages in terms of sensitivity, throughput, and cost compared with conventional diagnostic methods such as physical examination. 10 Among the diagnostic spectrometry methods, MALDI MS 14,21 and SERS 22,23 are two prominent emerging tools. In MALDI MS, matrix materials determine the LDI efficiency with identication of diverse molecules over a broad mass range.…”

TiO2 Nanocoral Structures as Versatile Substrates for Surface‐Assisted Laser Desorption/Ionization Mass Spectrometry

“…Various molecules such as peptides, drugs, carbohydrates, glycolipids, natural products, and polymers were successfully analyzed with excellent sensitivities using this type of substrate . Due to the success of DIOS substrates, the application of SALDI‐MS was investigated using various nano/micromaterials as substrates, including carbon and silicon‐based materials, metal nanoparticles, metal‐based nanomaterials with unique structures, and other inorganic materials . Among metal oxides, TiO 2 shows potential as a SALDI‐MS substrate.…”