Design of plasmonic nanomaterials for diagnostic spectrometry

Gurav, Deepanjali D.; Jia, Yi; Ye, Jian; Qian, Kun

doi:10.1039/c8na00319j

Cited by 50 publications

(21 citation statements)

References 67 publications

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“…The optical properties of AuNPs are dependent on surface plasmon resonance (SPR), which is the fluctuation and interaction of electrons between negative and positive charges at the surface ( Ramalingam, 2019 ). SPR can also be described in terms of surface plasmon polariton (SPP), which originates from propagating waves along a planar gold surface ( Gurav et al, 2019 ). Due to their unique optical and electrical properties, and economic importance, AuNPs have abundant applications in various interdisciplinary branches of science, including medicine, material science, biology, chemistry and physics ( Khan et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

347

206

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Nanotechnology has become a trending area in science and has made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for a wide range of medical applications. Among them, gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence and are highly remarkable. AuNPs, with their multiple, unique functional properties, and easy of synthesis, have attracted extensive attention. Their intrinsic features (optics, electronics, and physicochemical characteristics) can be altered by changing the characterization of the nanoparticles, such as shape, size and aspect ratio. They can be applied to a wide range of medical applications, including drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and radiation therapy (RT), diagnosis, X-ray imaging, computed tomography (CT) and other biological activities. However, to the best of our knowledge, there is no comprehensive review that summarized the applications of AuNPs in the medical field. Therefore, in this article we systematically review the methods of synthesis, the modification and characterization techniques of AuNPs, medical applications, and some biological activities of AuNPs, to provide a reference for future studies.

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Section: Introductionmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

347

206

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“…Yet, the majority of reported nanoplasmonic approaches are firmly ground at the level of proof-of-concept, displaying only incremental effects with limited scope. Although rational synthesis of plasmonic materials has been advancing tremendously in the past several years (Xi et al, 2018; Gurav et al, 2019), next-generation systems have not yet been realized and widespread clinical adoption is not feasible (Scarabelli, 2018). While plasmonics-based biosensing will certainly produce a huge impact on global health, particularly for low resource environments, there is still a long way to go.…”

Section: Future Outlookmentioning

confidence: 99%

Nanoplasmonic Approaches for Sensitive Detection and Molecular Characterization of Extracellular Vesicles

et al. 2019

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All cells release a multitude of nanoscale extracellular vesicles (nEVs) into circulation, offering immense potential for new diagnostic strategies. Yet, clinical translation for nEVs remains a challenge due to their vast heterogeneity, our insufficient ability to isolate subpopulations, and the low frequency of disease-associated nEVs in biofluids. The growing field of nanoplasmonics is poised to address many of these challenges. Innovative materials engineering approaches based on exploiting nanoplasmonic phenomena, i.e., the unique interaction of light with nanoscale metallic materials, can achieve unrivaled sensitivity, offering real-time analysis and new modes of medical and biological imaging. We begin with an introduction into the basic structure and function of nEVs before critically reviewing recent studies utilizing nanoplasmonic platforms to detect and characterize nEVs. For the major techniques considered, surface plasmon resonance (SPR), localized SPR, and surface enhanced Raman spectroscopy (SERS), we introduce and summarize the background theory before reviewing the studies applied to nEVs. Along the way, we consider notable aspects, limitations, and considerations needed to apply plasmonic technologies to nEV detection and analysis.

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“…SPRs can be described as surface plasmon polaritons (SPPs) or localized surface plasmon resonance (LSPR). SPPs originates from propagating waves along a plane metal surface while LSPR occurs when a SP is confined to a volume with dimension smaller than the wavelength of incident light for metal nanoparticles [2,33], as illustrated in Scheme 2. For Au NPs, many applications primarily depend on their LSPR properties, including LSPR sensing, SERS, and MEF.…”

Section: Optical Properties Of Au Nanoparticlesmentioning

confidence: 99%

“…Diagnostics are essential in biomedical science and clinical practice to improve global healthcare. Molecular diagnostic, one of the most important frontiers of modern medicine, relies on the efficient detection of biomarkers extracted from a bio-system to achieve disease diagnosis, evaluation of the disease stage, and monitoring of its progresses and treatment [1,2]. The detection of biomarkers in bio-fluids is promising in point-of-care (POC) applications due to its low invasiveness and high adaptability while the detection of biomarkers in tissues serves as the gold standard for precision diagnosis in pathological examination [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Over the past few decades, much progress has been made in the studies of the detection of biomarkers and their applications in diagnostics [6,7,8,9,10]. However, the sensitive and selective detection of biomarkers in real cases is still challenging owing to the high complexity of biological samples and low abundance of target molecules [2,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Optical Diagnostic Based on Functionalized Gold Nanoparticles

Zhou

Chen

et al. 2019

IJMS

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Au nanoparticles (NPs) possess unique physicochemical and optical properties, showing great potential in biomedical applications. Diagnostic spectroscopy utilizing varied Au NPs has become a precision tool of in vitro and in vivo diagnostic for cancer and other specific diseases. In this review, we tried to comprehensively introduce the remarkable optical properties of Au NPs, including localized surfaces plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and metal-enhanced fluorescence (MEF). Then, we highlighted the excellent works using Au NPs for optical diagnostic applications. Ultimately, the challenges and future perspective of using Au NPs for optical diagnostic were discussed.

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Design of plasmonic nanomaterials for diagnostic spectrometry

Abstract: Development of plasmonics for diagnostic spectrometry encompassing the interface, mechanism, and application of nanomaterials.

Cited by 50 publications

References 67 publications

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Nanoplasmonic Approaches for Sensitive Detection and Molecular Characterization of Extracellular Vesicles

Optical Diagnostic Based on Functionalized Gold Nanoparticles

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