Optical Diagnostic Based on Functionalized Gold Nanoparticles

Ou, Jiemei; Zhou, Zidan; Chen, Zhong; Tan, Huijun

doi:10.3390/ijms20184346

Cited by 42 publications

(31 citation statements)

References 125 publications

(165 reference statements)

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“…Diagnostics are very essential to medical science and clinical practice. Some diagnostic methods (such as immunoassay diagnosis) have been applied to clinical diagnosis but have limitations in precision molecular diagnostics because of their inaccuracy and low sensitivity ( Ou et al, 2019 ). With the development of nanotechnology, the sensitivity, specificity, and multiplexing of diagnostic tests have been improved.…”

Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

“…With the development of nanotechnology, the sensitivity, specificity, and multiplexing of diagnostic tests have been improved. AuNPs exhibit substantial and excellent optical properties, mainly including localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS), which play an important role in their application to diagnostics ( Ou et al, 2019 ; Venditti, 2019 ). LSPR-based application of AuNPs is due to spectral modulation ( Figure 11 ) ( Ou et al, 2019 ).…”

Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

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Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

348

206

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Nanotechnology has become a trending area in science and has made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for a wide range of medical applications. Among them, gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence and are highly remarkable. AuNPs, with their multiple, unique functional properties, and easy of synthesis, have attracted extensive attention. Their intrinsic features (optics, electronics, and physicochemical characteristics) can be altered by changing the characterization of the nanoparticles, such as shape, size and aspect ratio. They can be applied to a wide range of medical applications, including drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and radiation therapy (RT), diagnosis, X-ray imaging, computed tomography (CT) and other biological activities. However, to the best of our knowledge, there is no comprehensive review that summarized the applications of AuNPs in the medical field. Therefore, in this article we systematically review the methods of synthesis, the modification and characterization techniques of AuNPs, medical applications, and some biological activities of AuNPs, to provide a reference for future studies.

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Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

348

206

View full text Add to dashboard Cite

show abstract

“…Spherical nucleic acid Au NPs conjugates consisting of densely packed recognition oligonucleotides with complementary sequences to the target mRNA was studied. It was able to detect intracellular mRNA level [ 89 ]. Ultrasmall polyaminocarboxylate-coated Au NPs, a dithiolated derivative of diethylenetriaminepentaacetic acid, and 1,4,7,10-tetraazacyclododecan-1-glutaric acid-4,7,10-triacetic acid functionalized by thioctic acid show potential for image-guided radiotherapy.…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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“…The aggregation of AuNPs results in a pronounced color change from red to blue (shift to longer wavelengths) dependent on inter-particle distances ( Figure 6 ) [ 63 ]. Color changes of NPs are closely correlated with the resonance between an oscillation of electrons and the incident electromagnetic radiation [ 74 ]. It is worth mentioning that optical properties are changed with size for other types of NPs such as quantum dots [ 75 ], as well.…”

Section: Glycan-functionalized Nanoparticles (Nps)mentioning

confidence: 99%

Glycan Nanobiosensors

et al. 2020

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This review paper comprehensively summarizes advances made in the design of glycan nanobiosensors using diverse forms of nanomaterials. In particular, the paper covers the application of gold nanoparticles, quantum dots, magnetic nanoparticles, carbon nanoparticles, hybrid types of nanoparticles, proteins as nanoscaffolds and various nanoscale-based approaches to designing such nanoscale probes. The article covers innovative immobilization strategies for the conjugation of glycans on nanoparticles. Summaries of the detection schemes applied, the analytes detected and the key operational characteristics of such nanobiosensors are provided in the form of tables for each particular type of nanomaterial.

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Optical Diagnostic Based on Functionalized Gold Nanoparticles

Cited by 42 publications

References 125 publications

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Glycan Nanobiosensors

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