Plasmapheresis Therapy in Kidney Transplant Rejection

Xie, Ping; Tao, Min; Peng, Kanfu; Zhao, Hongwen; Zhang, Ke‐Qin; Sheng, Yuxiu; Ankawi, Ghada; Ronco, Claudio

doi:10.1159/000493521

Cited by 11 publications

(9 citation statements)

References 48 publications

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“…For cellular rejection, high-dose corticosteroids or lymphocyte-depleting agents are commonly used. For antibody-mediated rejection, an anti-CD20 antibody or plasmapheresis are applied [ 71 , 72 ].…”

Section: Covid-19 Vaccine Efficacy In Ckd Patients: From Ckd3-5 and Ckd-5d To Post Kidney Transplantationmentioning

confidence: 99%

The Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review

Hou

Kuo

2021

Vaccines

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The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic has posed a huge threat to global health because of its rapid spread and various mutant variants. Critical illness occurs in the elderly and vulnerable individuals, such as those with chronic kidney disease. The severity of SARS-CoV-2 infection is associated with the severity of chronic kidney disease (CKD)and even kidney transplantation (KT) because of the chronic use of immunosuppressive agents. To develop adaptive immunity against SARS-CoV-2, vaccination against the spike protein is important. Current phase III trials of vaccines against SARS-CoV-2 have not focused on a specific group of individuals, such as patients with CKD or those undergoing dialysis or kidney transplantation. Chronic use of immunosuppressive agents might disturb the immune response to the SARS-CoV-2 spike protein. On the basis of limited evidence, the immune compromised status of CKD patients might decrease neutralizing antibody development after a single dose of a specific vaccine. Boosting dosage more than the protocol might increase the titer of the neutralizing antibody in CKD patients. Further evidence is needed to understand the factors disturbing the immunogenicity of the SARS-CoV-2 vaccine, and CKD patients should receive the recommended dose of the SARS-CoV-2 vaccine due to their relatively immune compromised status.

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Section: Covid-19 Vaccine Efficacy In Ckd Patients: From Ckd3-5 and Ckd-5d To Post Kidney Transplantationmentioning

confidence: 99%

The Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review

Hou

Kuo

2021

Vaccines

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“…It is known that PP treatment is effective in antibody-mediated vascular rejection, and the nurse of the renal transplant unit is responsible for performing the technique, and should provide comprehensive assistance to the renal transplant patient. 12,13 It is specified that a study showed the role of the nurse, not only in the care of the renal transplant patient, but also as a health educator, offering adequate and effective guidelines. It is pointed out a significant concern on the part of Nursing to maintain care for the renal transplant within and outside the hospital, with guidelines that address simple and complex issues, which are of paramount importance during the pre-and post-transplant period, ensuring the success and quality of life of the transplant.…”

Section: Methods Resultsmentioning

confidence: 99%

Importância da assistência de enfermagem no cuidado ao paciente transplantado renal

Marques

Freitas²

2018

Rev enferm UFPE on line.

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RESUMOObjetivo: descrever a importância da assistência de Enfermagem ao paciente transplantado renal. Método: trata-se de um estudo bibliográfico, tipo revisão integrativa, na base de dados LILACS e bibliotecas virtuais SciELO e BVS, incluindo artigos completos, em português, inglês ou espanhol. Estabeleceu-se, um período de 15 anos para a inclusão dos estudos, e os resultados apresentam-se em figuras. Resultados: encontraram-se 1114 artigos, dos quais, após a leitura dos títulos e dos resumos e a aplicação dos critérios de inclusão e exclusão, foram selecionados dez, sendo dois na SciELO, três na BVS e quatro na LILACS. Verifica-se que os artigos abordam, de forma significativa, a relação dos diagnósticos de Enfermagem na elaboração de intervenções adequadas ao paciente. Conclusão: conclui-se que a Enfermagem possui um papel fundamental no sucesso, na recuperação e na melhoria da qualidade de vida do paciente transplantado renal. Descritores: Assistência ao Paciente; Cuidados de Enfermagem; Nefropatias; Pacientes; Sobrevida; Transplante de Rim.ABSTRACT Objective: to describe the importance of nursing care to the renal transplant patient. Method: this is a bibliographical study, type integrative, in the LILACS database and virtual libraries SciELO and VHL, including complete articles, in Portuguese, English or Spanish. A period of 15 years for the inclusion of the studies was established, and the results are presented in figures. Results: 1114 articles were found, of which, after reading titles and abstracts and applying the inclusion and exclusion criteria, ten were selected, two in SciELO, three in VHL and four in LILACS. It is verified that the articles approach, in a significant way, the relation of Nursing diagnoses in the elaboration of adequate interventions to the patient. Conclusion: it is concluded that Nursing plays a fundamental role in the success, recovery and improvement of the quality of life of the renal transplant patient. Descriptors: Patient Care; Nursing Care; Kidney Diseases; Patients; Survival; Kidney Transplantation.RESUMEN Objetivo: describir la importancia de la asistencia de enfermería al paciente trasplantado renal. Método: se trata de un estudio bibliográfico, revisión integrada de tipo, la base de datos LILACS y SciELO bibliotecas virtuales y BVS, incluyendo los artículos completos en portugués, inglés o español. Se estableció, un período de 15 años para la inclusión de los estudios, y los resultados se presentan en figuras. Resultados: se encontraron 1114 artículos, de los cuales, después de la lectura de los títulos y de los resúmenes y la aplicación de los criterios de inclusión y exclusión, fueron seleccionados diez, siendo dos en la SciELO, tres en la BVS y cuatro en la LILACS. Se verifica que los artículos abordan de forma significativa la relación de los diagnósticos de Enfermería en la elaboración de intervenciones adecuadas al paciente. Conclusión: se concluye que la Enfermería tiene un papel fundamental en el éxito, la recuperación y la mejora de la calidad de vida del paciente trasplantado renal. Descriptores: Atención al Paciente; Atención de Enfermería; Enfermedades Renales; Pacientes; Supervivencia; Trasplante de Riñón.

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“…Additional benefit of IVIG is its ability to replenish gamma globulin lost during therapeutic apheresis, decreasing infection risk [49].…”

Section: Ivigmentioning

confidence: 99%

“…Both immunoabsorption (IA) and plasmapheresis (PP) are known to lower HLA-specific antibody levels in a variety of clinical settings [49]. Despite the substantial reductions in the titer of donor-specific anti-HLA antibodies achieved by IA and PP, the graft survival in these patients is significantly reduced, due to rebound synthesis of de novo alloantibodies.…”

Section: Plasmapheresismentioning

confidence: 99%

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Antibody Mediated Rejection in Kidney Transplant Recipients

Kojc¹,

Haler²

2019

Perioperative Care for Organ Transplant Recipient

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Antibody mediated rejection (ABMR) presents a significant challenge for long term graft survival in kidney transplantation. New technologies, including genomic studies and assays to detect and define donor-specific antibodies, have provided important insights into the pathophysiology and diagnosis of ABMR. Unfortunately, this progress has not yet translated into better outcomes for patients, as in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This chapter reviews the current understanding of ABMR, and details its diagnosis, and treatments, both those established in current routine clinical practice and those on the horizon.

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Plasmapheresis Therapy in Kidney Transplant Rejection

Cited by 11 publications

References 48 publications

The Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review

The Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review

Importância da assistência de enfermagem no cuidado ao paciente transplantado renal

Antibody Mediated Rejection in Kidney Transplant Recipients

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