Plasma Thyroxine and Cholesterol Concentrations of Miniature Pigs Are Influenced by Thermally Oxidized Dietary Lipids

Eder, Klaus; Stangl, Gabriele I.

doi:10.1093/jn/130.1.116

Cited by 35 publications

(23 citation statements)

References 39 publications

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“…Hochgraf et al (Hochgraf et al 1997) demonstrated that oxidized linoleic acid, which is present in sunflower seeds, promotes a significant increase in the plasma cholesterol levels in rats. In contrast, some other studies reported reduced levels of plasma cholesterol and triglycerides in rats and pigs in response to the consumption of oxidized dietary oil (Eder and Kirchgessner 1999;Eder 1999;Eder and Stangl 2000;Eder et al 2003;Acikgoz et al 2011). In this context, our results demonstrated increased cholesterol levels with HFD, which agrees with the proposed of Hochgraf et al (Hochgraf et al 1997).…”

Section: Discussionmentioning

confidence: 92%

Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats

Souza

Stolf

Dreifuss

et al. 2015

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 92%

Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats

Souza

Stolf

Dreifuss

et al. 2015

Braz. arch. biol. technol.

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“…Thermally oxidized fats contain a large number of lipid peroxidation products that are known to affect the animal metabolism in several ways [1]. Recent studies have shown that dietary thermally oxidized fats increase the concentrations of free and total thyroxine in plasma of rats [2] and miniature pigs [3]. This indicates that oxidized fats could play a role in the etiology of thyroid disorders such as hyperthyroidism.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Dietary Thermally Oxidized Fat on Thyroid Morphology and mRNA Concentrations of Thyroidal Iodide Transporter and Thyroid Peroxidase in Rats

et al. 2003

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Background/Aim: Recent studies demonstrated that feeding oxidized fats increases the concentrations of total and free thyroxine in blood of rats and pigs. This finding suggested that oxidized fats affect the function of the thyroid gland. This study investigates the effects of a thermally oxidized dietary fat on the morphology of the thyroid gland and on the expression of proteins (Na⁺/I^– symporter, thyroid peroxidase) involved in the synthesis of thyroid hormones in rats at different dietary iodine concentrations. Methods: An experiment was conducted with 48 growing male Sprague-Dawley rats which were allotted to four groups of 12 animals each. According to a bifactorial experimental design, the rats received semisynthetic diets with 10% of either a fresh or an oxidized fat, with low (50 µg/kg) or adequate (400 µg/kg) iodine concentrations, over a period of 38 days. The oxidized fat was prepared by heating sunflower oil at a temperature of 55°C for a period of 5 weeks. The oxidized fat had much higher concentrations of lipid peroxidation products than the fresh fat as assessed by determining the peroxide concentrations (877 vs. 33 mEq O₂/kg) and those of thiobarbituric acid reactive substances (25 vs. 0.7 µmol/kg). Results: Rats fed the diets containing oxidized fat had higher concentrations of total and free thyroxine in plasma, a greater height of thyroid epithelial cells, a smaller diameter of thyroid follicle lumen, a lower Na⁺/I^– symporter mRNA concentration, and a higher thyroid peroxidase mRNA concentration than rats fed the fresh fat (p < 0.05 for all effects). The concentrations of triiodothyronine and thyrotropin were not different between rats fed the fresh fat and those fed the oxidized fat. The dietary iodine supply also had significant effects on some of the parameters analyzed. There were no interactions between type of fat and dietary iodine concentrations. Conclusion: The rat model used here shows that dietary oxidized fats affect the morphology and the function of the thyroid gland, irrespective of the dietary iodine supply.

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“…Takeuchi et al (1995) fed rats a feed containing lard, sunflower oil or linseed oil in amounts of 200 g/kg and observed a significant increase in the level of triiodothyronine in response to vegetable oils. Eder and Stangl (2000), in turn, found a significant rise in the level of thyroxine, from 42.5 nmol/1 to 56.0 nmol/1, and an increase in the T4/T3 ratio in the plasma of miniature pigs fed a feed containing 15% sunflower oil oxidized at 110°C in comparison with fresh oil.…”

Section: Discussionmentioning

confidence: 85%

“…Eder and Stangl (2000) demonstrated a significant negative correlation between thyroxine and cholesterol levels in the blood plasma of pigs.…”

Section: Discussionmentioning

confidence: 91%

The effect of feeding sows conjugated linoleic acid (CLA) in late pregnancy on blood thyroid hormone and cholesterol levels in piglets

Pietras¹,

Barowicz²,

Pieszka³

2002

J. Anim. Feed Sci.

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The effect of CLA supplementation of feeds for sows in late pregnancy on thyroid hormone, total cholesterol and cholesterol fraction (LDL and HDL) concentrations in the serum of piglets was determined. The experiment was conducted on 8 lactating sows (Large White x Polish Landrace) divided into two groups. The sows were fed a complete granulated feed with free access to water. From day 90 of pregnancy to delivery, the sows received a 4% addition of sunflower seed oil or CLA oil (EDENOR UKD 6010, Henkel). Samples of colostrum were taken 24 h after delivery. Milk samples were taken 3 h after the morning feeding on days 8 and 21 of lactation. On day 21, blood from the jugular vein was sampled from two piglets in each litter for determination of thyroid honnone, total cholesterol, HDL and LDL cholesterol. The addition of CLA to the rations of the experimental sows late in pregnancy increased the level of conjugated Hnoleic acid in colostrum in comparison with the control group (P<0.001). On days 8 and 21 of lactation the CLA content of milk was lower than in colostrum (P<0.001). Significantly higher levels of thyroxine and triiodothyronine (P<0.05), lower total cholesterol and HDL (P<0.05) and LDL (P<0.01) levels were found in the blood plasma of piglets in the experimental group in comparison with those in the control group.The obtained results show that conjugated Hnoleic acid contained in the colostrum of sows increases plasma thyroid hormone levels in the blood of piglets and lowers the levels of total cholesterol and cholesterol fractions.

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Plasma Thyroxine and Cholesterol Concentrations of Miniature Pigs Are Influenced by Thermally Oxidized Dietary Lipids

Cited by 35 publications

References 39 publications

Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats

Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats

Effects of a Dietary Thermally Oxidized Fat on Thyroid Morphology and mRNA Concentrations of Thyroidal Iodide Transporter and Thyroid Peroxidase in Rats

The effect of feeding sows conjugated linoleic acid (CLA) in late pregnancy on blood thyroid hormone and cholesterol levels in piglets

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