Plasma polymerization for biomedical applications: A review

Coad, Bryan R.; Favia, Pietro; Vasilev, Krasimir; Griesser, Hans J.

doi:10.1002/ppap.202200121

Cited by 19 publications

(12 citation statements)

References 145 publications

(206 reference statements)

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“…[70] From the above assessment, mainly C 2 H 2 and C 2 H 4 are well-suited polymerizable monomers used, for example, to deposit hard coatings or diffusion-controlling layers. [71][72][73] However, they do not bear interesting functionalities, which is why they are also mixed with nonpolymerizable gases such as N 2 , NH 3 , CO 2 , CO, H 2 O, O 2 , and so on, to incorporate functional groups in a cross-linked hydrocarbon matrix. Importantly, the threshold energy for the hydrocarbon molecules, as derived from the Arrhenius-like approach, was found to be retained independent of the gas admixture.…”

Section: Plasma Polymerizationmentioning

confidence: 99%

Plasma activation mechanisms governed by specific energy input: Potential and perspectives

Hegemann

2023

Plasma Processes & Polymers

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In a low‐temperature plasma, the electrons pick up energy from the electric field in collisions with atoms and molecules, gaining high kinetic energy that must be sufficient for ionizing reactions to sustain the plasma. For molecular gases, an average energy per heavy gas particle is thus available in the plasma, the specific energy input, yielding plasma activation by inelastic collisions. Following a distribution law, the probability for the activation mechanism can be described by an Arrhenius‐like equation. The potential of this approach is demonstrated on the basis of plasma polymerization and plasma CO2 conversion. For perspective, energy efficiencies are discussed as a function of conversion indicating the optimum that can be achieved by electron impact activation compared with additional ways of energy transfer, probably depending on certain constraints.

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Section: Plasma Polymerizationmentioning

confidence: 99%

Plasma activation mechanisms governed by specific energy input: Potential and perspectives

Hegemann

2023

Plasma Processes & Polymers

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“…PECVD has also been employed as a method to enhance the resistance of biomaterials to degradation [89]. It has been demonstrated that PECVD of biocompatible diamond-like carbon (DLC) on metal surfaces reduces corrosion, making such coatings suitable for metal implants [90,91].…”

Section: Pecvdmentioning

confidence: 99%

Applications of soft biomaterials based on organic and hybrid thin films deposited from the vapor phase

Marcelja,

Demelius,

Ali

et al. 2023

J. Phys. Mater.

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Soft biomaterials are a crucial component in several application fields. They are used, for example, in biomedical implants, biosensors, drug delivery systems as well as in tissue engineering. In parallel to extensive ongoing efforts to synthesize new materials, the development of means to tailor the materials’ surface properties and thus their interaction with the environment is an important field of research. This has led to the emergence of several surface modification techniques that enable the exploitation of the modified materials in a broader range of technologies. In particular, the use of functional thin films can enable a plethora of biomedical applications, that benefit from the bulk properties of the substrate (e.g., flexibility, lightweight, structural strength) combined to the surface properties of the thin film (e.g, enhancing/prevention cell proliferation, controlled drug release). In addition, for some biomedical applications, the thin films can be the main functional components, e.g. in biosensors. The present review focuses on recent developments in the applications of soft biomaterials based on thin films deposited from the vapor phase. In the field of soft biomaterials, the possibility of depositing from the vapor phase - without the need for any solvents - offers the unprecedent benefit that no toxic leachables are included in the biomaterial. Further, due to the complete lack of solvents, and chemicals overall being used in small quantities only, depositing thin films from the vapor phase can be a more sustainable choice than other techniques that are commonly used.

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“…[ 10 ] Plasma polymerization introduces specific functional groups to the surface such as amines, carboxylic acids, aldehydes, and esters through the use of relevant volatile monomers. [ 11 ] Coupling agents such as carbodiimide and N ‐hydroxysuccinimide [ 12 ] react with these functional groups to covalently bind the biomolecules to the surface. Both aminosilanization and functional groups addition through plasma polymerization are time‐consuming processes with multiple steps.…”

Section: Introductionmentioning

confidence: 99%

Plasma‐Activated Coated Glass: A Novel Platform for Optimal Optical Performance and Cell Culture Substrate Customization

Tran,

Gilmour,

Boumelhem

et al. 2024

Small Science

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Borosilicate glass surpasses polystyrene in optical quality; however, it is less frequently used for cell culture due to poor protein and cell adhesion. To overcome this impasse, the surface of glass coverslips requires functionalization to enable facile covalent attachment of proteins to promote cell attachment and differentiation. Herein, a novel approach is presented to covalently attach proteins to glass by depositing a thin layer of radical‐rich carbon film using a plasma polymerization process. The surface chemistry of these plasma‐activated coatings can be controlled by varying the gas composition used during the deposition. Mass spectrometry reveals different protein profiles attached to functionalized glass coverslips when they are exposed to cell culture media. Mouse embryonic stem cell adhesion and subsequent differentiation into neural lineage on plasma‐treated coverslips are significantly enhanced compared to bare coverslips. Importantly, the coatings are in the nanometer range, preserve the optical properties of the glass coverslips for imaging, and remain stable for at least 4 weeks in simulated body fluid. These results demonstrate the utility of covalently attaching proteins to glass for enhanced cell attachment and stem cell differentiation and provide a promising technique to achieve better outcomes in cell culture in a range of biomedical applications.

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Plasma polymerization for biomedical applications: A review

Cited by 19 publications

References 145 publications

Plasma activation mechanisms governed by specific energy input: Potential and perspectives

Plasma activation mechanisms governed by specific energy input: Potential and perspectives

Applications of soft biomaterials based on organic and hybrid thin films deposited from the vapor phase

Plasma‐Activated Coated Glass: A Novel Platform for Optimal Optical Performance and Cell Culture Substrate Customization

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