Plasma phospholipid fatty acid pattern in severe liver disease

Clemmesen, J; Høy, Carl‐Erik; Jeppesen, Palle Bekker; Ott, Peter

doi:10.1016/s0168-8278(00)80400-6

Cited by 23 publications

(17 citation statements)

References 32 publications

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“…Possible reasons include a poor dietary intake of LA and EPA, changes of Δ-6, Δ-5 and Δ-9 desaturase activity due to chronic alcohol consumption and hepatocellular insuficiency (42–44) and/or an increased degradation of PUFA due to lipid peroxidation. (45) Previously published data (46–48) suggest that a high level of palmitic acid in cirrhotic patients (found also in our study) is related to the cirrhotic process and not to alcohol consumption. High level of palmitic acid in our cirrhotic patients does not seem to be affected by malnutrition.…”

Section: Discussionsupporting

confidence: 81%

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

Ristić‐Medić

Takić

Vučić

et al. 2013

J. Clin. Biochem. Nutr.

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The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p<0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p<0.001) and ratio of n-6/n-3 fatty acids was higher (p<0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic acid and long-chain PUFA were found in well-nourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation.

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Section: Discussionsupporting

confidence: 81%

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

Ristić‐Medić

Takić

Vučić

et al. 2013

J. Clin. Biochem. Nutr.

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“…3,4 This is why impaired PUFA availability may occur in children with unbalanced diet, malabsorption or maldigestion syndrome 5 and diseases of the liver where chain elongation and desaturation of LC PUFA are mainly located. 6,7 Beyond limited bioavailability and metabolism, monitoring of the blood FA becomes increasingly important because a vast number of studies have reported a modified blood PUFA distribution in various diseases. In particular, the most common chronic childhood diseases 8,9 in western countries, for example, asthma, 10, 11, 12 cystic fibrosis, 13,14 obesity, 15,16 diabetes, 17,18 mental health problems especially depression 19,20 and attention-deficity/hyperactivity disorders (ADHD) 21,22 are associated with modifications of the blood FA composition.…”

Section: Introductionmentioning

confidence: 99%

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

et al. 2014

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Objectives:To establish reference values for fatty acids (FA) especially for n-3 and n-6 long-chain polyunsaturated FAs (LC PUFA) in whole-blood samples from apparently healthy 3–8-year-old European children. The whole-blood FA composition was analysed and the age- and sex-specific distribution of FA was determined.Design and subjects:Blood samples for FA analysis were taken from 2661 children of the IDEFICS (identification and prevention of dietary- and lifestyle-induced health effects in children and infants) study cohort. Children with obesity (n=454) and other diseases that are known to alter the FA composition (n=450) were excluded leaving 1653 participants in the reference population.Measurements:The FA composition of whole blood was analysed from blood drops by a rapid, validated gas chromatographic method.Results:Pearson correlation coefficients showed an age-dependent increase of C18:2n-6 and a decrease of C18:1n-9 in a subsample of normal weight boys and girls. Other significant correlations with age were weak and only seen either in boys or in girls, whereas most of the FA did not show any age dependence. For age-dependent n-3 and n-6 PUFA as well as for other FA that are correlated with age (16:0, C18:0 and C18:1n-9) percentiles analysed with the general additive model for location scale and shape are presented. A higher median in boys than in girls was observed for C20:3n-6, C20:4n-6 and C22:4n-6.Conclusions:Given the reported associations between FA status and health-related outcome, the provision of FA reference ranges may be useful for the interpretation of the FA status of children in epidemiological and clinical studies.

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“…However, FA abnormalities have also been described in cholestasis (21,22) and cirrhosis (23,24). We studied the differences in PL-FA composition in CF patients with a severe genotype, with or without CF related liver disease (CFRLD).…”

Section: Introductionmentioning

confidence: 99%

Fatty acid composition of serum phospholipids in cystic fibrosis (CF) patients with or without CF related liver disease

Biervliet

Biervliet²,

Robberecht³

et al. 2010

Clinical Chemistry and Laboratory Medicine

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Plasma phospholipid fatty acid pattern in severe liver disease

Cited by 23 publications

References 32 publications

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

Fatty acid composition of serum phospholipids in cystic fibrosis (CF) patients with or without CF related liver disease

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