“…3,4 This is why impaired PUFA availability may occur in children with unbalanced diet, malabsorption or maldigestion syndrome 5 and diseases of the liver where chain elongation and desaturation of LC PUFA are mainly located. 6,7 Beyond limited bioavailability and metabolism, monitoring of the blood FA becomes increasingly important because a vast number of studies have reported a modified blood PUFA distribution in various diseases. In particular, the most common chronic childhood diseases 8,9 in western countries, for example, asthma, 10, 11, 12 cystic fibrosis, 13,14 obesity, 15,16 diabetes, 17,18 mental health problems especially depression 19,20 and attention-deficity/hyperactivity disorders (ADHD) 21,22 are associated with modifications of the blood FA composition.…”