Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

Wolters, Maike; Schlenz, H.; Foraita, Ronja; Galli, Cláudio; Risé, Patrizia; Moreno, Luís A.; Molnár, Denés; Russo, Paola; Veidebaum, Toomas; Tornaritis, Michael; Vyncke, Krishna; Eiben, Gabriele; Iacoviello, Licia; Ahrens, Wolfgang

doi:10.1038/ijo.2014.139

Cited by 29 publications

(33 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study determined whole blood fatty acid levels and did not find any association of age and gender with EPA, DPA and DHA levels except that EPA was much lower in the 7-year-old age group. A heterogeneous cohort of European children 3 to 8 years old from 8 countries who were well nourished the median EPA levels in the age groups 7 to 9 years was higher compared with our study findings [30]. However, the median DPA and DHA levels were lower by almost half the quantities found in our study.…”

Section: Omega 3 Fatty Acid Levels and Age/gendercontrasting

confidence: 77%

Whole Blood Omega 3 Fatty Acid Levels of HIV Exposed and HIV Unexposed 7 - 10 Years Old Children from a Low Income Country with High Burden of Under-Nutrition

Kuona¹,

Mashavave²,

Dzangare³

et al. 2015

FNS

View full text Add to dashboard Cite

Long chain polyunsaturated fatty acids are essential macronutrients that have several benefits which have been described for children's health. Omega 3 LCPUFA metabolism has been reported to be altered in under-nourished and in HIV infected children. Therefore, we describe Eicosapentaenoic acid, Docosapentaenoic acid and Docosahexaenoic acid levels of HIV infected, HIV exposed uninfected and HIV unexposed uninfected school aged children from a low income country with a high burden of HIV infection and under-nutrition. This cross-sectional study recruited children 7 to 10 years old. Capillary blood was collected on filter paper and whole blood fatty acid analysis done using automated gas liquid chromatography. Kruskal Wallis and Median tests were used to compare the distribution and medians of the Omega 3 LCPUFA among the children according to HIV status, gender, age and nutritional status. A total of 318 children were recruited with 21 (7%) being HIV infected and 116 (37%) being HIV exposed uninfected. Chronic malnutrition was present in 12% of the children. The omega 3 fatty acids were expressed as percent weight of total fatty acids. The medians (interquartile range) for EPA, DPA and DHA for all the children were 0. 19 (0.09), 0.79 (0.19) and 2.14 (0.54) %wt/wt respectively. EPA, DPA and DHA levels were not associated with the HIV status of the children. EPA levels were much lower in the 7-year-age group compared with the 8 and 9 -10-year-age groups. Further studies assessing LCPUFA levels that include larger sample size, children from both urban and rural areas are recommended as this may P. Kuona et al. 486 assist in clearly defining the association of LCPUFA with HIV status in children from low income countries with high burden of under-nutrition.

show abstract

Section: Omega 3 Fatty Acid Levels and Age/gendercontrasting

confidence: 77%

Whole Blood Omega 3 Fatty Acid Levels of HIV Exposed and HIV Unexposed 7 - 10 Years Old Children from a Low Income Country with High Burden of Under-Nutrition

Kuona¹,

Mashavave²,

Dzangare³

et al. 2015

FNS

View full text Add to dashboard Cite

show abstract

“…Hence, desaturase activities may help to identify subjects for whom preventive measures are required. In this context, the recently defined reference values for the estimated desaturase activity in children provide a basis for evaluation (35).…”

Section: Resultsmentioning

confidence: 99%

“…Fasting blood samples were obtained by collecting a drop of blood from a fingertip or by venipuncture. FA in whole blood were separated and determined by a validated gas-liquid chromatography (GLC) method (GC) after direct derivatisation to their methyl esters without prior extraction of total lipids from the samples as described previously (35)(36)(37)(38). The estimated desaturase activities were determined from the product-precursorratios as follows: D9D: 16:1n-7/16:0, D6D: 20:3n-6/18:2n-6, D5D: 20:4n-6/20:3n-6.…”

Section: Anthropometric Measurements Blood Sampling and Analysismentioning

confidence: 99%

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Wolters

Schlenz

Börnhorst

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…FA in whole blood were separated and determined by gas-liquid chromatography after direct derivatisation to their methyl esters without prior extraction of total lipids from the samples in a central laboratory as previously described [30, 31]. This simple and rapid analysis method was validated by several laboratories [31–33].…”

Section: Methodsmentioning

confidence: 99%

Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents – Results from the IDEFICS/I.Family Cohort

et al. 2016

View full text Add to dashboard Cite

BackgroundPolyunsaturated n-3 and n-6 polyunsaturated fatty acids (PUFA) are precursors of biologically active metabolites that affect blood pressure (BP) regulation. This study investigated the association of n-3 and n-6 PUFA and BP in children and adolescents.MethodsIn a subsample of 1267 children aged 2–9 years at baseline of the European IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort whole blood fatty acids were measured by a validated gas chromatographic method. Systolic and diastolic BP was measured at baseline and after two and six years. Mixed-effects models were used to assess the associations between fatty acids at baseline and BP z-scores over time adjusting for relevant covariables. Models were further estimated stratified by sex and weight status.ResultsThe baseline level of arachidonic acid was positively associated with subsequent systolic BP (β = 0.08, P = 0.002) and diastolic BP (β = 0.07, P<0.001). In thin/normal weight children, baseline alpha-linolenic (β = -1.13, P = 0.003) and eicosapentaenoic acid (β = -0.85, P = 0.003) levels were inversely related to baseline and also to subsequent systolic BP and alpha-linolenic acid to subsequent diastolic BP. In overweight/obese children, baseline eicosapentaenoic acid level was positively associated with baseline diastolic BP (β = 0.54, P = 0.005).ConclusionsLow blood arachidonic acid levels in the whole sample and high n-3 PUFA levels in thin/normal weight children are associated with lower and therefore healthier BP. The beneficial effects of high n-3 PUFA on BP were not observed in overweight/obese children, suggesting that they may have been overlaid by the unfavorable effects of excess weight.

show abstract

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

Cited by 29 publications

References 50 publications

Whole Blood Omega 3 Fatty Acid Levels of HIV Exposed and HIV Unexposed 7 - 10 Years Old Children from a Low Income Country with High Burden of Under-Nutrition

Whole Blood Omega 3 Fatty Acid Levels of HIV Exposed and HIV Unexposed 7 - 10 Years Old Children from a Low Income Country with High Burden of Under-Nutrition

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents – Results from the IDEFICS/I.Family Cohort

Contact Info

Product

Resources

About