Plasma oxidized low-density lipoprotein level and miRNA-146a gene expression, as a strong predictor for atherosclerotic coronary artery disease and its associated response to atorvastatin in a sample of the Iraqi population

ApoB gene polymorphism (rs676210) and its pharmacogenetics impact on atorvastatin response among Iraqi population with coronary artery disease

“…In the previous of our publication, some demographic characteristics were studied and demonstrated. However, the mean age, gender, weight, height, BMI, SBP, DBP, and drinking habit differed non significantly between the two study groups (P< 0.05; Table 2) [16].…”

Gene Expression and Methylation Levels of PCSK9 Gene in Iraqi Patients with Coronary Artery Disease

“…The study was ethically approved by the Ministry of Health in Iraq (decree order 3310 on 08/12/2021), through the Scientific Committee of the College of Biotechnology, Al-Nahrain University, carried out between December 2021 and May 2022. Patients diagnosed with ASCAD with TC usually greater than 200mg/dl and LDL-C greater than 160mg/dl (hypercholesterolemia), triglycerides (TG) less than 200 mg/dl whose other lipid levels were normal according to the American heart association (AHA) guidelines, coronary angiography technique should be included with criteria equal to or more than 50 percent stenosis of at least one major coronary vessel due to atherosclerosis and confirmed by two experienced cardiologists ASCAD, and normolipidemic subjects with LDL-C less than 130 mg/dl and TG less than 150 mg/dl 4 . Exclusion criteria were: subjects with the presence of hypertension were previously diagnosed to have hypertension by a clinician.…”

“…A Receiver Operator Curve (ROC) was used to discover if the study parameter could be predictive of ASCAD 4 . As displayed in Table 5, the serum PCSK9 level in a patient with atherosclerotic coronary artery disease has a high predictor of ASCAD with AUC=0.98, with the best Cutioffivalue = 226.29ng/ml, sensitivity 93.20%, and specificity 100%, and displayed a significant difference P= 0.00.…”

“…Those who are uncontrollable (conventional) are: Gender (men are generally at higher risk of CAD); age (simply getting older raises the risk); as well as family history 3 . The initial soft lesion is composed of extracellular fat deposits, foam cells, and a small number of platelets 4 . In Iraq, as stated by the world health organization (WHO), CVD is the major cause of mortality in Iraq exceeding 18.50% of total mortality in 2017 and Iraq ranked the 19th internationally 5 .…”