Plasma oxidative parameters and mortality in patients with severe burn injury

Ritter, Cristiane; Andrades, Michael Éverton; Guerreiro, Márcio Osório; Zavaschi, Leonardo; Gelain, Daniel Pens; Souza, Luís Fernando de; Ribeiro, Cyntia Aguiar; Clausell, Nadine Oliveira; Menna-Barreto, Sérgio Saldanha; Moreira, José Cláudio Fonseca; Dal‐Pizzol, Felipe

doi:10.1007/s00134-003-1833-9

Cited by 31 publications

(18 citation statements)

References 15 publications

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“…The evolution of plasma TBARs after burn showed an unexpected decrease in the two groups. However, Lipid peroxidation after burn injury has been largely documented in humans [31,71,72] and animals [73,74]. In the present study and contrastly to selenium [67], zinc status does not seem to be determinant to protect lipids from burn-induced free radical production.…”

Section: Impact Of Low Zinc Status On Burn-induced Oxidative Stresscontrasting

confidence: 81%

Burn-induced Oxidative Stress is Altered by a Low Zinc Status: Kinetic Study in Burned Rats Fed a Low Zinc Diet

Claeyssen

Andriollo-Sanchez

Arnaud

et al. 2008

Biol Trace Elem Res

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As an initial subdeficient status of zinc, considered as an essential antioxidant trace element, is frequent in burned patients, we aim to assess the effects of low zinc dietary intakes on burn-induced oxidative stress, in an animal model. After 8 weeks of conditioning diets containing 80 ppm (control group) or 10 ppm of zinc (depleted group), Wistar rats were 20% TBSA burned and sampled 1-10 days after injury. Kinetic evolutions of zinc status, plasma oxidative stress parameters, and antioxidant enzymes were also studied in blood and organs. The zinc-depleted diet induced, before injury, a significant decrease in zinc bone level and the increase of oxidative stress markers without stimulation of antioxidant enzyme activity. After burn, more markedly in zinc depleted animals than in controls, zinc levels decreased in plasma and bone, while increasing in liver. The decrease of thiol groups and GSH/GSSG ratio and the depression of GPx activity in liver are also moderately emphasized. Nevertheless, depleted zinc status could not be considered as determining for oxidative damages after burn injury. Further investigations must also be done to enlighten the mechanism of beneficial effects of zinc supplementation reported in burned patients.

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Section: Impact Of Low Zinc Status On Burn-induced Oxidative Stresscontrasting

confidence: 81%

Burn-induced Oxidative Stress is Altered by a Low Zinc Status: Kinetic Study in Burned Rats Fed a Low Zinc Diet

Claeyssen

Andriollo-Sanchez

Arnaud

et al. 2008

Biol Trace Elem Res

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“…In a rat model of traumatic brain injury (TBI), an increase in biochemical markers of oxidative and nitrosative stresses were recorded with a concomitant decrease in antioxidants such as ascorbic acid and glutathione [5]. Similar findings have been reported in other conditions such as acute lung injury and severe burn injury [6,7]. Obviously, measuring multiple biochemical parameters, such as total antioxidants, lipid peroxidation, free radical production, protein oxidation, and/or enzyme activity, is time consuming and impractical in a clinical setting.…”

Section: Introductionmentioning

confidence: 65%

Injury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective analysis

Rael

Bar-Or

Salottolo

et al. 2009

Scand J Trauma Resusc Emerg Med

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BackgroundIn critical injury, the occurrence of increased oxidative stress or a reduced antioxidant status has been observed. The purpose of this study was to correlate the degree of oxidative stress, by measuring the oxidation-reduction potential (ORP) of plasma in the critically injured, with injury severity and serum amyloid A (SAA) levels.MethodsA total of 140 subjects were included in this retrospective study comprising 3 groups: healthy volunteers (N = 21), mild to moderate trauma (ISS < 16, N = 41), and severe trauma (ISS ≥ 16, N = 78). For the trauma groups, plasma was collected on an almost daily basis during the course of hospitalization. ORP analysis was performed using a microelectrode, and ORP maxima were recorded for the trauma groups. SAA, a sensitive marker of inflammation in critical injury, was measured by liquid chromatography/mass spectrometry.ResultsORP maxima were reached on day 3 (± 0.4 SEM) and day 5 (± 0.5 SEM) for the ISS < 16 and ISS ≥ 16 groups, respectively. ORP maxima were significantly higher in the ISS < 16 (-14.5 mV ± 2.5 SEM) and ISS ≥ 16 groups (-1.1 mV ± 2.3 SEM) compared to controls (-34.2 mV ± 2.6 SEM). Also, ORP maxima were significantly different between the trauma groups. SAA was significantly elevated in the ISS ≥ 16 group on the ORP maxima day compared to controls and the ISS < 16 group.ConclusionThe results suggest the presence of an oxidative environment in the plasma of the critically injured as measured by ORP. More importantly, ORP can differentiate the degree of oxidative stress based on the severity of the trauma and degree of inflammation.

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“…OS due to effect of dengue infection on protein-bound sulphydryls in human plasma is not well understood [6] . In dengue patients, increased levels of total antioxidant status (TAS) like SOD, GSH, and LPO have been observed, and decreased levels of glutathione peroxidase (GPx) and total hydroperoxides (THP) have been observed as compared to normal [7] .…”

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confidence: 97%

Assessment of biochemical and antioxidative status in patients suffering from dengue fever

Rasool

Malik

Khan

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever (DF) by evaluating biochemical and oxidative status of patients. ELISA IgM antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) showed significant difference. Significant increases in serum alanine amino transferase (ALT) (P=0.000), aspartate amino transferase (AST) (P=0.000), alkaline phosphatase (ALP) (P=0.000), malondialdehyde (MDA) along with significant decreases in total protein (TP) (P=0.000), reduced glutathione (GSH) (P=0.000), superoxide dismutase (SOD), catalase (CAT) (P=0.000), and sialic acid contents (P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants (r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

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Plasma oxidative parameters and mortality in patients with severe burn injury

Cited by 31 publications

References 15 publications

Burn-induced Oxidative Stress is Altered by a Low Zinc Status: Kinetic Study in Burned Rats Fed a Low Zinc Diet

Burn-induced Oxidative Stress is Altered by a Low Zinc Status: Kinetic Study in Burned Rats Fed a Low Zinc Diet

Injury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective analysis

Assessment of biochemical and antioxidative status in patients suffering from dengue fever

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