Plasma levels of antioxidant<i>β</i>‐carotene and α‐tocopherol in uterine cervix dysplasias and cancer

Palan, Prabhudas R.; Mikhail, Magdy S.; Basu, Jayasri; Romney, Seymour L.

doi:10.1080/01635589109514106

Cited by 126 publications

(37 citation statements)

References 29 publications

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“…However, most other studies have found no association of risk of cervical neoplasia with either dietary or serum retinol (Marshall et al, 1983;Harris et al, 1986;Brock et al, 1988;La Vecchia et al, 1988;Palan et al, 1988Palan et al, , 1991Verreault et al, 1989;Cuzick et al, 1990;Ziegler et al, 1990;De Vet et al, 1991;Herrero et al, 1991). Relationships of dietary carotenoids to risk of cervical neoplasia have been inconsistent in previous studies (Marshall et al, 1983;Harris et al, 1986;Brock et al, 1988;La Vecchia et al, 1988;Palan et al, 1988;Cuzick et al, 1990;Ziegler et al, 1990;De Vet et al, 1991;Herrero et al, 1991;VanEenwyk et al, 1991).…”

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confidence: 70%

Serum carotenoids and vitamins and risk of cervical dysplasia from a case–control study in Japan

et al. 1999

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SummaryThe relationships between risk of cervical dysplasia and dietary and serum carotenoids and vitamins were investigated in a case-control study. Cases were 156 women who attended Papanicolaou test screening in nine institutes affiliated with Japan Study Group of Human Papillomavirus (HPV) and Cervical Cancer and had cervical dysplasia newly histologically confirmed. Age-matched controls were selected from women with normal cervical cytology attending the same clinic. Blood sample and cervical exfoliated cells were obtained for measuring serum retinol, α-carotene, β-carotene, zeaxanthin/lutein, cryptoxanthin, lycopene and α-tocopherol and for HPV detection. Higher serum level of α-carotene was significantly associated with decreased risk of cervical dysplasia after controlling for HPV infection and smoking status (odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.04-0.62 for the highest as compared with the lowest tertile). Decreased risk for the highest tertile of serum lycopene (OR = 0.28) was marginally significant. Decreased risks observed for the highest tertiles of β-carotene (OR = 0.65) and zeaxanthin/lutein (OR = 0.53), were not statistically significant. © 1999 Cancer Research Campaign Keywords: cervical dysplasia; carotenoids; human papillomavirus; diet 1234British Journal of Cancer (1999) 81(7), 1234-1237© 1999 Cancer Research Campaign Article no. bjoc.1999 Received 12 November 1998 Revised 8 April 1999 Accepted 13 April 1999Correspondence to: C Nagata Serum carotenoids and cervical dysplasia 1235British Journal of Cancer (1999) 81(7), 1234-1237 © 1999 Cancer Research Campaign match) after the identification of case was approached. About 90% of the first eligible controls agreed to participate in the study.A self-administered questionnaire including demographic factors, smoking and drinking habits, diet, reproductive history and sexual behaviour was distributed to each case and control when she visited the institute to know the result of Papanicolaou test. Diet was assessed by asking about the intake amounts of 22 foods that are retinol-and carotene-rich during the past 7 days. Daily intake of retinol and carotene were estimated using the Standard Tables of Food Composition in Japan (4th revised edition published by the Science and Technology Agency of Japan). The detailed information about the dietary questionnaire including validity was described elsewhere (Shimizu et al, 1996). A total of 167 cases and matched controls responded to the questionnaire.Blood sampling as well as collection of cervical smear samples were performed on the same day. Serum was isolated and frozen at -80°C. The fraction of carotenoids, retinol and tocopherol of the serum samples were extracted into n-hexane, and the concentrations of α-carotene, β-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and α-tocopherol were determined by high-performance liquid chromatography (HPLC) using a slight modification of Nells and Leenheer's method (Nells and De Leenheer, 1983). The serum of cases and matched controls was a...

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confidence: 70%

Serum carotenoids and vitamins and risk of cervical dysplasia from a case–control study in Japan

et al. 1999

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“…The reduced glutathione levels in the plasma and buccal mucosa were determined by the method described by Beutler and Kelly (1963). The vitamin E level in the plasma was determined colorimetrically using the method described by Palan et al (1973). Buccal mucosa vitamin E was measured using the fluorimetric method described by Desai (1984).…”

Section: Biochemical Estimationsmentioning

confidence: 99%

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Manoharan

Wani²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Our aim was to investigate the chemopreventive potential of saffron in DMBA-induced hamster buccal pouch carcinogenesis. Assessment was by monitoring the percentage of tumor bearing hamsters, tumor size as well as the status of detoxification agents, lipid peroxidation and antioxidants. Oral squamous cell carcinomas were induced in the buccal pouch of Syrian golden hamsters by painting them with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. We observed 100% oral tumor formation with severe histopathological abnormalities in all the hamsters treated with DMBA alone, activities of phase I and phase II detoxification enzymes, lipid peroxidation and antioxidants being significantly altered. Though oral administration of saffron completely prevented the formation of tumors, we noticed severe hyperplasia and dysplasia in hamsters treated with DMBA, suggesting that tumors might eventually develop. Oral administration of saffron return detoxification enzymes, lipid peroxidation and antioxidants to normal ranges. The chemopreventive potential of saffron thus is likely due to antioxidant properties and modulating effects on detoxification in favour of the excretion of carcinogenic metabolites during DMBA-induced hamster buccal pouch carcinogenesis.

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“…Vitamin E was determined by Palan et al (1973) method. To 0.5 ml of supernatant, 1.5 ml of ethanol was added, appropriately mixed and centrifuged.…”

Section: Total Protein (Tp) -Albumin (Alb)mentioning

confidence: 99%

Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats

Ujowundu¹,

Igwe²,

Alisi³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl 4 ) induced toxicity. Twenty five male Wistar albino rats were grouped and treated, thus: group I served as normal control, groups II, IV and V were given single dose of 1.2 ml CCl 4 /kg body weight (bwt). Groups IV and V were administered 1.4 and 2.8 ml AB/kg bwt, respectively, while group III animals were administered 1.4 ml AB/kg bwt. Results obtained showed significant (p<0.05) increase in lipid peroxidation and in activities of liver function enzymes, reductions in glutathione concentration and activities of catalase, glutathione peroxidase and reductase in groups administered AB and CCl 4 only as well as in groups treated with AB after CCl 4 exposure. These observations indicate manifestation of oxidative stress induced by excessive consumption of high percentage alcoholic content of the bitter. Similarly, the result trends of other antioxidant parameters studied indicated significant oxidative damage and thus the inability of the alcoholic bitter to ameliorate xenobiotics induced damage.

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Plasma levels of antioxidantβ‐carotene and α‐tocopherol in uterine cervix dysplasias and cancer

Cited by 126 publications

References 29 publications

Serum carotenoids and vitamins and risk of cervical dysplasia from a case–control study in Japan

Serum carotenoids and vitamins and risk of cervical dysplasia from a case–control study in Japan

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats

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