Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients

El-Kader, Shehab M Abd; Al-Jiffri, Osama H; Al-Shreef, Fadwa M

doi:10.4314/ahs.v16i2.19

Cited by 15 publications

(23 citation statements)

References 50 publications

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“… 100 , 101 In general, longer periods of regular exercise training show a decrease of many inflammatory cytokines such as TNF-α, IL-2, IL-4, and CRP in COPD patients. 102 Similarly, in murine models, a reduced expression of cell surface markers on circulating immune cells such as vascular adhesion molecule-1 (VCAM-1), ICAM-1, and CD62L was shown after regular treadmill running. Also several other inflammatory cytokines such as IL-1α, MCP-3, MIP-1β, MIP-1α, and CD40L were shown to decrease in smoke-exposed mice after training.…”

Section: Immune-regulating Effects Of Exercise Trainingmentioning

confidence: 97%

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Madani¹,

Alack²,

Richter³

et al. 2018

JIR

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Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system. In the pulmonary system of cigarette smokers, oxidative stress, cellular damage, and a chronic activation of pattern recognition receptors are described which are followed by the translocation of the NF-kB, the release of pro-inflammatory cytokines, chemokines, matrix metalloproteases, and damage-associated molecular patterns. In parallel, smoke pollutants cross directly through the alveolus–capillary interface and spread through the systemic bloodstream targeting different organs. Consequently, LTCS induces a systemic low-grade inflammation and increased oxidative stress in the vascular system. In blood, these processes promote an increased coagulation and endothelial dysfunction. In muscle tissue, inflammatory processes activate catabolic signaling pathways followed by muscle wasting and sarcopenia. In brain, several characteristics of neuroinflammation were described. Regular exercise training has been shown to be an effective nonpharmacological treatment strategy in smoke-induced pulmonary diseases. It is well established that exercise training exerts immune-regulating effects by activating anti-inflammatory signaling pathways. In this regard, the release of myokines from contracting skeletal muscle, the elevations of cortisol and adrenalin, the reduced expression of Toll-like receptors, and the increased mobilization of immune-regulating leukocyte subtypes might be of vital importance. Exercise training also increases the local and systemic antioxidative capacity and several compensatory mechanisms in tissues such as an increased anabolic signaling in muscle or an increased compliance of the vascular system. Accordingly, regular exercise training seems to protect long-term smokers against some important negative local and systemic consequences of smoking. Data suggest that it seems to be important to start exercise training as early as possible.

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Section: Immune-regulating Effects Of Exercise Trainingmentioning

confidence: 97%

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Madani¹,

Alack²,

Richter³

et al. 2018

JIR

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“…In 2010, Van der Vlist et al (van der Vlist and Janssen, 2010 ) conducted a literature review and concluded that endurance or resistance training showed beneficial effects on physical parameters in COPD, despite the absence of any decrease in inflammatory mediators. In 2016, Abd El-Kader et al ( 2016 ) compared the response of inflammatory cytokines after aerobic vs. resistance training and showed that mean values of TNF-α, IL-2, IL-4, IL-6, and C-reactive protein (CRP) were significantly reduced in both groups after 12 weeks of exercise training.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and Metabolic Responses to Different Resistance Training on Chronic Obstructive Pulmonary Disease: A Randomized Control Trial

et al. 2018

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Background: Low-grade inflammation can be present in chronic obstructive pulmonary disease (COPD), which may affect the regulation of muscle protein and body metabolism. Regular exercise show improvement in muscle strength and dyspnea in patients with COPD, however, the response to training on inflammatory and metabolic disorders is unclear. In this study, we compared the effects of resistance training using weight machines and elastic resistance (bands and tubes) on the inflammatory and metabolic responses in patients with COPD.Methods: Patients with COPD were randomized into three groups: elastic band group (EBG), elastic tube group (ETG), and weight machines equipment group (MG). EBG and ETG were analyzed together [elastic group (EG)]. The participants were evaluated for pulmonary function (spirometry), peripheral muscle strength (digital dynamometry), IL-6, TNF-α, IL-10, IL-15 (Immunoassay), glucose, triacylglycerol, total cholesterol, HDL-c, and albumin levels (Enzymatic colorimetric). Blood samples were collected to assess the acute and chronic exercise responses after 12 weeks of training protocol.Results: The patient's mean age was 71.53 ± 6.97 years old. FEV1 (percent predicted) was 50.69 ± 16.67 and 45.40 ± 15.15% for EG and MG, respectively (p = 0.28). All groups increased muscle strength (p < 0.05) with no differences between groups. The acute response to exercise after 12 weeks of training showed improvement of inflammation when compared to baseline. Regarding the chronic effects, it was observed a decrease of all cytokines, except IL-10 (p < 0.05). After 12 weeks of training, the analysis of the metabolic profile presented a reduction in glucose concentration (p < 0.01), with no differences between groups (p = 0.30) and a decrease in triacylglycerol for the EG (p > 0.01).Conclusions: Training with elastic resistances or conventional weight machines showed improvement of inflammation response after 12 weeks of training. Chronically, both training groups showed anti-inflammatory effects, with the EG showing a strong tendency to improve IL-10/TNF-α ratio and IL-10 levels.Trial registration : RBR-6V9SJJ.

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“…All studies found that pulmonary rehabilitation programs or individual physical therapy programs were effective in improving the quality of life [12][13][14][15][16][17], physical endurance [12][13][14][15][16][18][19][20][21][22][23], respiratory muscle strength [13,18,23], reducing symptoms of CoPd [14,16,19,23], improving the function of external breathing [16,[24][25][26], blood parameters [22,27], cognitive functions [21], functional state of muscles [28], survival rates [29,30], and reducing the number of hospital days [31]. The main part of investigations was devoted to the comparison of therapeutic rehabilitation programs that included several components and referred to stable patients with CoPd.…”

Section: Resultsmentioning

confidence: 99%

Physical therapy in chronic obstructive pulmonary disease (analysis of the evidence-based medicine)

Tymruk-Skoropad¹,

Tsizh²,

Vynogradskyi³

et al. 2018

Physiother Quart.

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Introduction. The purpose of the study is to present the forms of rehabilitation used in chronic obstructive pulmonary disease (CoPd) in various centres. Widespread occurrence of CoPd, significant disability, high treatment costs, permanently increasing and more profound knowledge about the pathogenesis and course of CoPd lead to a comprehensive study of respiratory rehabilitation and physical therapy of the disease. Conclusions. in evidence-based medicine databases, in the total number of the published research results pertaining to CoPd, the proportion of studies on rehabilitation makes up 9.8-15.95%, and that of physical therapy constitutes 3.8-11.5%. Taking into consideration the conclusions of systematic reviews with reference to the key role of rehabilitation and physical therapy in the CoPd patients' treatment, close attention should be focused currently on the identification of indispensable components of respiratory rehabilitation and the evaluation of its efficacy.

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Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients

Cited by 15 publications

References 50 publications

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Inflammatory and Metabolic Responses to Different Resistance Training on Chronic Obstructive Pulmonary Disease: A Randomized Control Trial

Physical therapy in chronic obstructive pulmonary disease (analysis of the evidence-based medicine)

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