Plasma hypoxanthine levels in newbom infants: A specific indicator of hypoxia

Saugstad, Ola Didrik; Gluck, Louis

doi:10.1515/jpme.1982.10.6.266

Cited by 56 publications

(29 citation statements)

References 24 publications

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“…In an other clinical study [21] the correlation between hypoxanthine on the one and pH or base deficit on the other side are very high. However, they are determined essentially by the extremes, fairly compatible with survival and were treated among our patients.…”

Section: Discussionmentioning

confidence: 80%

“…Since the 1950's the determination of lactate [5] has been discussed in this respect; more recently work by SAUGSTAD [17,18] in determining hypoxanthine levels in the plasma of neonates has found wide attention. Elevated hypoxanthine levels under hypoxic conditions have been documented in many studies in animals [19,20,22,24,25], as well as human newborns |2, 7, 13,17,21,23]. In this work we will present reference data of hypoxanthine and lactate levels in healthy mature newborns in the first five days of life, as well as those in newborns requiring oxygen therapy, and those in well prematures.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns

Jung¹,

Lun²,

Zinsmeyer³

et al. 1985

Journal of Perinatal Medicine

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 96%

The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns

Jung¹,

Lun²,

Zinsmeyer³

et al. 1985

Journal of Perinatal Medicine

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show abstract

“…Further, it has, by now, been well established that hypoxanthine accumulates in tissues (33), plasma (30,32,34,35), and other body fluids (12,23,25) during hypoxia. When high concentrations of oxygen are administered to the hypoxic patient, large amounts of free radicals may be produced by the hypoxanthine/xanthine oxidase system.…”

Section: Abbreviationmentioning

confidence: 99%

Hypoxanthine and Oxygen Induced Lung Injury: A Possible Basic Mechanism of Tissue Damage?

et al. 1984

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Summaryoxygen exposure with simultaneous intravenous hypoxanthine infusion. Lung injury was induced in young rats by a continuous infusion of hypoxanthine intravenously and breathing 100% oxygen for 48 h (group 1). Control animals were rats infused glucose and MATERIALS AND METHODSbreathing 100% oxygen (group 2), rats infused hypoxanthine in room air (group 3), and untreated rats (group 4). In group 1 rats interstitial and alveolar edema was found with a tendency toward marked margination of polymorphonuclear neutrophils in small vessels (P < 0.025 compared with group 2). The main elastase inhibitor alphal-antitrypsin (a-1-PI) was significantly elevated in group 1; 2-, 3-and 5-fold, respectively, when compared with groups 2, 3, and 4. The surfactant phopholipids from alveolar lavage were normal in all groups. The protein-rich fraction of the lavage fluid from group I rats inactivated, however, the surface properties of lung surfactant. Minimum surface tension in group 1 rats was 14.5 dyn/cm compared with 7.0 dyn/cm in group 2, 2.9 dyn/cm in group 3 and 3.5 dyn/cm in group 4 (P < 0.05, group 1 and 2 versus 4). We conclude that the combination of hypoxanthine and high levels of oxygen causes lung injury, possibly via free oxygen radicals. We discuss the possibility that these findings demonstrate a basic pathogenetic mechanism for the hypoxic-hyperoxic insult and can contribute to the understanding of pathogenesis of a variety of diseases both in pediatrics and adult medicine. AbbreviationFree oxygen radicals have been shown to destroy cell membranes by lipid peroxidation (3, 8, 1 1, 2 1). It has been suggested that such radicals play an important role in the pathogenesis of the acute and chronic lung damage among patients treated with oxygen. Many authors have, however, suggested that oxygen must be combined with other more or less unknown factors, before injury occurs ( 14,27).Recently, it has been shown that the hypoxanthine/xanthine oxidase system generates free radicals (7), and that this system potently induces inflammatory changes both in the hamster cheek pouch (22) and the rat lung (16). Further, it has, by now, been well established that hypoxanthine accumulates in tissues (33), plasma (30,32,34,35), and other body fluids (12,23,25) during hypoxia. When high concentrations of oxygen are administered to the hypoxic patient, large amounts of free radicals may be produced by the hypoxanthine/xanthine oxidase system. We, therefore, have raised the question whether the combination of hypoxanthine and oxygen is more damaging than high oxygen alone to the lung. In the present study we evaluated this by investigating experimentally the effect on the rat lung to 100% Young female rats of the Wistar strain, weighing 170-230 g, were used. Four groups were investigated. Group 1, rats infused continuously with 5 mM hypoxanthine dissolved in 5% glucose and exposed to 98-100% oxygen (n = 10). Group 2, rats infused continuously with 5% glucose and exposed to 98-100% oxygen (n = 9). Group 3, rats infused continuously wit...

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“…The literature suggests that the hypoxanthine concentration relates more to postnatal than intranatal hypoxia [1,13,15].…”

Section: Discussionmentioning

confidence: 99%

“…Les distributions de frequence cumulative des naissances normales et compliquees (figure 2) ne varient pas assez pour garantir Putilisation des concentrations d'hypoxanthine dans les vaisseaux ombilicaux comme parametre de distinction entre les nouveaux-nes hypoxiques et non hypoxiques. La litterature suggere que les concentrations d'hypoxanthine depistent plus les hypoxies post-natales qu'intranatales [1,13,15].…”

Section: Introductionunclassified

The relationship of hypoxia to hypoxanthine concentration during pregnancy and delivery

Issel

Lun²,

Pohle³

et al. 1988

Journal of Perinatal Medicine

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Plasma hypoxanthine levels in newbom infants: A specific indicator of hypoxia

Cited by 56 publications

References 24 publications

The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns

The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns

Hypoxanthine and Oxygen Induced Lung Injury: A Possible Basic Mechanism of Tissue Damage?

The relationship of hypoxia to hypoxanthine concentration during pregnancy and delivery

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