The relationship of hypoxia to hypoxanthine concentration during pregnancy and delivery

Issel, E. P.; Lun, Andreas; Pohle, R; Gross, Johann

doi:10.1515/jpme.1988.16.2.99

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…In experiments with rats, severe hypoxia led to increased hypoxanthine levels and decreased ATP levels in both CSF and brain tissues [112]. The first studies of plasma concentrations of hypoxanthine in humans were performed with cord blood, with increased levels being detected in children with hypoxia [113]; these results have been confirmed by other authors [113][114][115][116][117][118][119][120][121][122], (Table 8), who have reported that hypoxanthine level in cord blood is negatively correlated with Apgar score, and positively correlated with lactate level [96]. It has been suggested that hypoxanthine level is a better predictor of hypoxia-related sequelae than Apgar score or lactate level [96,117,123].…”

Section: Hypoxanthine and Xanthinementioning

confidence: 74%

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Biochemical parameters predictive of neuronal damage in children with neonatal hypoxic ischemia

Castro-Gago

2015

J Pediatr Neurol

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On the basis of the physiopathological mechanisms involved in the brain damage related to hypoxic-ischemic encephalopathy of the newborn, a number of metabolic parameters have been studied with the aim to provide an early and reliable marker of tissue injury for diagnostic and prognostic purpose. Some authors have even suggested that biochemical indicators may be more effective than the results of clinical, Apgar score, pH in cord blood, electroencephalographic and neuroimaging data. In the present review, we discuss the diagnostic and prognostic value of a series of biochemical parameters, with special reference to the diagnosis of neonatal hypoxic-ischemic encephalopathy. For methodological purpose the exposition is structured in the following sections: creatine kinase isoenzymes; lactate; lactate dehydrogenase, aspartate aminotransferase and hydroxibutirate dehydrogenase; excitatory amino acids; glial fibrillary acidic protein; cytokines; neuron-specific enolase; oxypurines; cyclic adenosine monophosphate; and others. The current role of the above mentioned biochemical parameters as predictors of brain damage and the future perspectives on this topic are discussed.

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Section: Hypoxanthine and Xanthinementioning

confidence: 74%

“…19.2 ± 5.8 (n = 4) < 0.005 Issel et al [121] 5.1 ± 1.8 (n = 28) 10.0 ± 3.4 (n = 3) < 0.01 Russell et al [122] 7.8 (2.4-48.9) (n = 8) * 31.9 (7.1-142.9) (n = 7) * < 0.005 NS = Not significant. * = Data are expressed as median (range).…”

Section: Referencesmentioning

confidence: 92%