Plasma homocysteine and folate levels in patients with chronic plaque psoriasis

Malerba, Mario; Gisondi, Paolo; Radaeli, Alessandro; Sala, Raffaella; Calzavara‐Pinton, Piergiacomo; Girolomoni, Giampiero

doi:10.1111/j.1365-2133.2006.07503.x

Cited by 130 publications

(160 citation statements)

References 41 publications

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“…However, unlike these results, patients with psoriasis were found to have high blood homocysteine in other five studies again in our country and five in Italy and one each in Ireland and Norway [20][21][22][23][24][25][26][27][28][29][30][31] . In the literature, studies showing psoriasis being accompanied by high blood homocysteine seem to be predominant (Table 3).…”

contrasting

confidence: 42%

“…After the studies made in 1990s where high levels of homocysteine were found in plasma samples of subjects who had or would likely to have a history of myocardial infarction, ischemic stroke or peripheral vascular disease and the association of homocysteine with atherosclerosis and hypercoagulability had been shown [6][7][8][9][10][11][12] , along with increased attention to the comorbidities of psoriasis, as far as we know, 19 studies have been conducted to explore homocysteine levels in these patients. Homocysteine level was found to be high in 12 and normal in 7 of these studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] . Since this sulfur-containing amino acid is not taken through diet and not producing protein, homocysteine is formed via methionine catabolism 8,11,27 .…”

Section: Introductionmentioning

confidence: 99%

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Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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contrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

View full text Add to dashboard Cite

show abstract

“…Mean plasma homocysteine levels were significantly higher than sex and age matched controls. 29 While Cakmak et al 30 did not observe significant differences in homocysteine, they found that homocysteine levels correlated with Psoriasis Areas and Severity Index (PASI) in the psoriasis group. It is important to note that homocysteine may be a surrogate marker of CVD rather than an etiologic factor, as recent studies of pharmacotherapy to lower homocysteine levels have not impacted vascular outcomes.…”

Section: -27mentioning

confidence: 99%

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

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“…Five mg Folic acid week 1 followed by 1 mg for the next 3 weeks given to patients with plasma Hcy over 15 umol/L reduces chemokines from mononuclear cells [6]. Plasma Hcy correlates directly and FA levels inversely with psoriasis area and severity index (PASI) [7]. Plasma folic acid levels inversely correlate with PASI [8].…”

Section: Introductionmentioning

confidence: 99%

“…A past study showed no benefit treating psoriasis with 6 weeks of twice daily FA 5 milligrams (mg) and 1-2000 micrograms (mcg) B12 [7]. We, however, have published case reports where FA (5-6 mg daily) with vitamins B6 (100 mg daily) and B12 (1000 mcg daily) improves psoriasis in two alcoholics and clears palmar plantar pustulosis, a disorder genetically related to some psoriasis through the CARD14 gene [11,12].…”

Section: Introductionmentioning

confidence: 99%

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson¹

2017

J Transl Sci

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The daily intake of FA of 5% Americans age 50 and over and in one study of psoriatic American women is about 1 mg. A patient with plaque psoriasis on 10 mg lisinopril did not improve on vitamins B12 and B6 alone. When folic acid 5 mg daily was added PASI improved 50%. Three cases of plaque psoriasis flared when given 1-2 mg folic acid (FA), 100 mg vitamin B6 and 1000 mcg daily B12. When daily FA was increased to 4 to 7 mg daily all three cases improved their disease.

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Plasma homocysteine and folate levels in patients with chronic plaque psoriasis

Abstract: Patients with psoriasis may have a tendency to hyperhomocysteinaemia, which may predispose to higher cardiovascular risk. Dietary modification of this risk factor appears relevant to the global management of patients with moderate to severe psoriasis.

Cited by 130 publications

References 41 publications

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

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