Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson, Peter J.

doi:10.15761/jts.1000193

Cited by 4 publications

(6 citation statements)

References 41 publications

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“…High levels of folic acid and vitamin B12 are known to improve the pathological condition related to psoriasis. 57 As reported in Table 2 , our data indicated low levels of folic acid and vitamin B12 at T0, whereas an increase in the concentration was registered at T1. Hypocalcemia was observed as a risk factor in psoriasis.…”

Section: Discussionsupporting

confidence: 70%

“…Biochemical and clinical parameters indicated a general improvement in the metabolites’ concentration known to be related to the condition of psoriasis: folic acid, vitamin B12, calcium, bilirubin, cortisol, LDL, and total cholesterol. High levels of folic acid and vitamin B12 are known to improve the pathological condition related to psoriasis . As reported in Table , our data indicated low levels of folic acid and vitamin B12 at T0, whereas an increase in the concentration was registered at T1.…”

Section: Discussionmentioning

confidence: 97%

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Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

et al. 2020

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Psoriasis is an inflammatory disease of the epidermis based on an immunological mechanism involving Langerhans cells and T lymphocytes that produce pro-inflammatory cytokines. Genetic factors, environmental factors, and improper nutrition are considered triggers of the disease. Numerous studies have reported that in a high number of patients, psoriasis is associated with obesity. Excess adipose tissue, typical of obesity, causes a systemic inflammatory status coming from the inflammatory active adipose tissue; therefore, weight reduction is a strategy to fight this pro-inflammatory state. This study aimed to evaluate how a nutritional regimen based on a ketogenic diet influenced the clinical parameters, metabolic profile, and inflammatory state of psoriasis patients. To this end, 30 psoriasis patients were subjected to a ketogenic nutritional regimen and monitored for 4 weeks by evaluating the clinical data, biochemical and clinical parameters, NMR metabolomic profile, and IL-2, IL-1β, TNF-α, IFN-γ, and IL-4 concentrations before and after the nutritional regimen. Our data show that a low-calorie ketogenic diet can be considered a successful strategy and therapeutic option to gain an improvement in psoriasis-related dysmetabolism, with significant correction of the full metabolic and inflammatory status.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

et al. 2020

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“…The results indicate neither a beneficial nor an adverse effect. Aronson [125] reported that a patient with plaque psoriasis on 10 mg lisinopril did not improve on vitamins B12 and B6 alone. When folic acid (FA) 5 mg daily was added PASI improved by 50%.…”

Section: Targeting Hcy As a Strategy For Treatment Of Psoriasismentioning

confidence: 99%

Homocysteine and psoriasis

Lin

Meng²,

Song

2019

Bioscience Reports

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Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the production of the pro-inflammatory cytokines in related to psoriasis. Hcy can induce nuclear factor kappa B activation, which is critical in the immunopathogenesis of psoriasis. There may be a link between the oxidative stress state in psoriasis and the effect of HHcy. Hydrogen sulfide (H2S) may play a protective role in the pathogenesis of psoriasis and the deficiency of H2S in psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of psoriasis is most likely established, Hcy can be a potential therapeutic target for the treatment of psoriasis. Systemic folinate calcium, a folic acid derivative, and topical vitamin B12 have found to be effective in treating psoriasis.

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“…Moreover, a significant reduction in the standard parameters was recorded (DLQI, VAS pain, and VAS pruritus), while PASI scores showed a significant 50% reduction [ 7 ]. Ps is known to lead to deregulated biochemical parameters in terms of folic acid, vitamin B12, calcium, bilirubin, cortisol, LDL, and total cholesterol [ 143 ]. After the diet, all these parameters significantly improved.…”

Section: Nutritional Therapeutical Strategies In Psoriasismentioning

confidence: 99%

Insights into Nutritional Strategies in Psoriasis

et al. 2023

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Psoriasis, an autoimmune chronic inflammatory skin condition, has a high incidence in the general population, reaching 2–4%. Its pathogenesis involves an interplay of genetic factors, immune disturbances, and environmental factors. Within the environmental factors that aid the appearance of this autoimmune skin disease, the Western lifestyle and overall diet play important roles in the steady growth in psoriasis prevalence. Furthermore, psoriasis is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Accumulating evidence suggests that obesity is an important risk factor for psoriasis. Moreover, obesity aggravates established psoriasis, and a reduction in the body mass index can improve the clinical outcomes of psoriasis and increase the efficacy of standard psoriasis therapies. The possible connection between this autoimmune disease and obesity relies on the fact that white adipose tissue is an essential endocrine organ that secretes an array of immune mediators and inflammatory and metabolic factors with pro-inflammatory action. Thus, immune-mediated mechanisms in both psoriasis and obesity conditions are common factors. This paper describes the factors that link obesity with skin autoimmune disease and highlights the importance of the stimulatory or regulatory effects of nutrients and food in psoriasis and the possible improvement of psoriasis through nutritional strategies.

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Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Cited by 4 publications

References 41 publications

Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

Homocysteine and psoriasis

Insights into Nutritional Strategies in Psoriasis

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