Plasma Exchange in Acute Polyneuropathy

Vanderheyden, Jean-Émile; Kennès, Bernard; Bain, H; Hubert, Cédric; Nève, Pierre

doi:10.1080/22953337.1979.11718692

Cited by 10 publications

(3 citation statements)

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“…Consistent with this hypothesis is the occurrence of GBS in higher than expected frequency after administration of vaccines, both those containing neural tissue as well as those which presumably do not [4,52,571. In addition, there are many similarities between experimental allergic neuritis (EAN), a paralytic disorder that occurs in susceptible animals after inoculation with peripheral nerve antigen, and GBS [67]. The neural lesions in EAN, an immune-mediated disorder, are highly characteristic and virtually indistinguishable from those seen in GBS [6,32,67,701.…”

Section: Evidence For Immunopathogenesis Of Gbsmentioning

confidence: 99%

“…In addition, there are many similarities between experimental allergic neuritis (EAN), a paralytic disorder that occurs in susceptible animals after inoculation with peripheral nerve antigen, and GBS [67]. The neural lesions in EAN, an immune-mediated disorder, are highly characteristic and virtually indistinguishable from those seen in GBS [6,32,67,701. Further, evidence of a hyperactive immune response is present in many patients with GBS.…”

Section: Evidence For Immunopathogenesis Of Gbsmentioning

confidence: 99%

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The role of autoantibody and immune complexes in the pathogenesis of Guillain-Barre syndrome

1981

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Section: Evidence For Immunopathogenesis Of Gbsmentioning

confidence: 99%

Section: Evidence For Immunopathogenesis Of Gbsmentioning

confidence: 99%

The role of autoantibody and immune complexes in the pathogenesis of Guillain-Barre syndrome

1981

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“…Some recent case reports have indicated that plas¬ mapheresis may be of value in the treatment of the acute and chronic forms of GBS. [8][9][10][11][12][13] In the present study, treatment by plasmapheresis was un¬ dertaken with varying success in eight patients with GBS.…”

mentioning

confidence: 99%

Treatment of the Guillain-Barre Syndrome by Plasmapheresis

Osterman¹,

Fagius²,

Säfwenberg³

et al. 1982

Archives of Neurology

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Treatment of acute inflammatory polyneuropathy

1981

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Most patients with acute inflammatory polyneuropathy (AIP) recover spontaneously, but the time course of the illness is unpredictable so that the results of treatment are difficult to assess. Three decades of retrospective reports of steroid treatment fail to demonstrate any striking beneficial effect. In a randomized trial of prednisolone, starting dose 60 mg daily, 21 treated patients improved more slowly than 19 untreated patients. By contrast, in rats immunized with bovine nerve root myelin, prednisolone at 10 mg/kg reduced the severity and duration of experimental allergic neuritis (EAN), the putative animal model for AIP. This discrepancy might reflect the greater difficulty of clinical as opposed to animal therapeutic trials or indicate that EAN is not the appropriate model for the human disease. Immunosuppressive drugs, plasmapheresis and other agents have also been employed, but their efficacy cannot be decided from the available case report. The role of similar agents in chronic progressive and relapsing inflammatory neuropathy cannot yet be resolved, but in some patients steroids do appear to be valuable.

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Plasma Exchange in Acute Polyneuropathy

Cited by 10 publications

References 0 publications

The role of autoantibody and immune complexes in the pathogenesis of Guillain-Barre syndrome

The role of autoantibody and immune complexes in the pathogenesis of Guillain-Barre syndrome

Treatment of the Guillain-Barre Syndrome by Plasmapheresis

Treatment of acute inflammatory polyneuropathy

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