Treatment of the Guillain-Barre Syndrome by Plasmapheresis

Osterman, P. O.; Fagius, Jan; Säfwenberg, Jan; Danersund, Antero; Wallin, B. Gunnar; Nordesjö, Lars‐Olof

doi:10.1001/archneur.1982.00510150018005

Cited by 37 publications

(7 citation statements)

References 30 publications

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“…Also the time in the respirator was significantly shortened among those given plasma exchange com pared to those not so treated. General care may have been more intensive also, so that comparisons are perhaps not valid [7,13,14], The need for hospitalization was equally long in non-exchanged and plasma-exchanged groups. Of course, more severely paralyzed cases were overrepresented in the plasma-exchange group.…”

Section: Discussionmentioning

confidence: 99%

Survey of Guillain-Barré Syndrome in Southern Finland

1991

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All acute Guillain-Barré syndrome (GBS) cases identified in the county of Uusi-maa in southern Finland from 1981–1985 were analyzed. The incidence varied from 0.5 to 2.1 per 100,000 population. An antecedent event of possible etiologic significance was reported in 10% of the cases. Plasma exchange therapy was introduced during these years. Less children than expected fell ill, perhaps because of vaccinations, but a rise in the incidence of GBS in 1985 occurred during a nation-wide oral poliovirus vaccination campaign. A total of 19.4% of the patients needed respirator treatment, and plasma exchange therapy was given to 27.4% of these patients, among whom the time in respirator was shortened compared to equally affected individuals not given plasma exchange. The mortality was lower in the recent compared to the earlier period. This may be due to plasma exchange therapy.

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Section: Discussionmentioning

confidence: 99%

Survey of Guillain-Barré Syndrome in Southern Finland

1991

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“…Plasmapheresis was reported to improve the clinical course of GBS and chronic relapsing inflammatory polyneuropathy [21,67,84,96,123]. Nevertheless, within the time this treatment can be effective, most untreated patients will improve spontaneously.…”

Section: Experimental Models and Guillain-barr6 Syndromementioning

confidence: 99%

Immunology of Guillain-Barré syndrome

Steiner

Abramsky

1985

Springer Semin Immunopathol

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“…However, in our experience, these agents have not proved effective and are rarely justified, since they may further compromise an aiready perilous clinical situation. Treatment of Guillain-Barre patients with plasmapheresis (Osterman et al, 1982) sometimes leads to a rapid dramatic improvement of clinical signs. This suggests the involvement of circulatory factors in the pathogenesis of this disease, as has also been indicated by immunocytochemical studies (Dalakas and Engel, 1980;Nyland et al, 1981) and experimental data .…”

Section: Clinical Featuresmentioning

confidence: 99%

Myelin

1984

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Treatment of the Guillain-Barre Syndrome by Plasmapheresis

Cited by 37 publications

References 30 publications

Survey of Guillain-Barré Syndrome in Southern Finland

Survey of Guillain-Barré Syndrome in Southern Finland

Immunology of Guillain-Barré syndrome

Myelin

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