“…For example, injections of ACTH, corticosterone or deoxycorticosterone will induce ovulation (van Tienhoven, 1961 ; Etches & Cunningham, 1976) and LH release (Wilson & Sharp, 1976a, Etches & Croze, 1983), injections of dexamethasone will inhibit ovulation and LH release (Soliman & Huston, 1974;Wilson & Lacassagne, 1978) and injections of metyrapone will alter the normal timing of LH release (Wilson & Cunningham, 1981). However, the relevance of the adrenal to normal ovarian function is difficult to test because the amount of corticosterone or ACTH required to induce ovulation exceeds the normal physiological range (Sharp & Beuving, 1978;Etches & Croze, 1983). Furthermore, the physiological interpretation of the effects of drugs such as dexamethasone and metyrapone is complicated by the lack of knowledge of their target tissues and their complete array of effects.…”