Effects of Administration of Adrenocorticotropin, Corticosteroids and Adrenal Inhibitor Metyrapone on Adrenocortical, Pineal and Gonadal Activity in Nocturnal bird, Athene brama and Diurnal bird, Perdicula asiatica

Sudhakumari, C.C.; Haldar, Chandana

doi:10.2108/zsj.18.81

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The detailed reproductive activity in relation to melatonin level and other endocrine organs for this Indian quail species has already been published (15). P asiatica experiences a strong winter stress (i.e.…”

Section: Discussionmentioning

confidence: 99%

Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, Perdicula Asiatica: An in Vivo and in Vitro Study

2010

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Inverse relationship between circulatory levels of glucocorticoids and melatonin has been reported for most of the vertebrates including human beings. We report the importance of glucocorticoid along with melatonin in avian immune regulation in an Indian tropical bird, Perdicula asiatica with in vivo and in vitro approach. Dexamethasone (30llg/bird/day) treatment of the male birds suppressed the immune activity as judged by the spleen activity (mass, anatomy), circulating total leukocyte, and lymphocyte count, blastogenic response, increased % apoptosis and cytokine (IL-2) production by splenocytes. Melatonin (25Ilg/100g B.wt.lday) treatment increased the above-mentioned immune parameters whereas melatonin together with dexamethasone restored the suppressed immune parameters by dexamethasone to control level. In vitro melatonin (2.5 pM) supplementation to splenocyte cultures restored the dexamethasone (211M) suppressed splenocyte proliferation, % apoptosis and IL-2 production. Therefore, melatonin antagonized the suppressive effect of synthetic glucocorticoid on all immune parameters studied in vivo as well as in vitro. Furthermore, exogenous administration of dexamethasone and melatonin treatment altered the circulatory level of corticosterone and melatonin in an inverse manner. It is therefore, suggested that a hormonal trade-off between glucocorticoid and melatonin exists under in vivo and in vitro conditions, being involved in maintenance of the immune function of P. asiatica probably by involving cytokines i,e. IL-2 mediated pathway.

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Section: Discussionmentioning

confidence: 99%

Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, Perdicula Asiatica: An in Vivo and in Vitro Study

2010

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“…In the present scenario of our understanding of pineal-adrenal relationship, it appears to be quite rewarding to study the effect of corticoid inhibitor, metyrapone on such an inconclusive relationship. It needs to be emphasized that vivid search of scientific literature fails to report influence of metyrapone, a corticoid inhibitor simultaneously on pineal and adrenal cytology and function in a single animal species, although it was reported that adrenal gland inhibitor metyrapone elevated pineal gland mass in diurnal bird (Sudhakumari and Halder, 2001). Consequently, the present communication is aimed to offer a first time evidence of the study of the influence of corticoid inhibitor, metyrapone on pineal -adrenal karyomorphology, dynamics and its effect on adrenal content of corticosterone hormone in postpubertal male mice.…”

Section: Introductionmentioning

confidence: 99%

Metyrapone, a corticoid inhibitor, induces inverse changes in pineal and adrenal karyomorphology, dynamics and function in mice (Mus musculus)

2010

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The relationship between pineal and adrenocortical cell morphology, dynamics and function awaits in depth investigation in mammals. In particular, any studies relating these two glands in response to potent adrenocorticoid inhibitor inducing changes in their functional and hormonal relationship appear to be absent. In our present study, we have attempted to investigate the pineal gland and adrenocortical responsiveness from combined morphological and associated hormonal studies. The present experiment utilized postpubertal male mice to study such an interrelationship. Our results reveal that metyrapone, a potent corticoid blocker, at a dose of 50 mg / 100 g body weight, for ten consecutive days induced significant stimulatory changes of the pineal cytomorphology, hypertrophy and hyperplasia, whereas, simultaneously there has been a suppression of adrenal cell morphology and function along with a decreased adrenal corticosterone content (control 0.24±0.08µg/g adrenal tissue vs. metyrapone 0.10±0.01 µg/g adrenal tissue). It may be surmised from the present investigation that corticoid inhibitor, metyrapone simultaneously causes inverse changes in pineal and adrenal function in postpubertal male mice.

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Seasonal changes in adrenal and gonadal activity in the quail, Perdicula asiatica: involvement of the pineal gland

Sudhakumari

Haldar

Senthilkumaran

2001

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Effects of Administration of Adrenocorticotropin, Corticosteroids and Adrenal Inhibitor Metyrapone on Adrenocortical, Pineal and Gonadal Activity in Nocturnal bird, Athene brama and Diurnal bird, Perdicula asiatica

Cited by 3 publications

References 31 publications

Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, Perdicula Asiatica: An in Vivo and in Vitro Study

Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, Perdicula Asiatica: An in Vivo and in Vitro Study

Metyrapone, a corticoid inhibitor, induces inverse changes in pineal and adrenal karyomorphology, dynamics and function in mice (Mus musculus)

Seasonal changes in adrenal and gonadal activity in the quail, Perdicula asiatica: involvement of the pineal gland

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