Seasonal changes in adrenal and gonadal activity in the quail, Perdicula asiatica: involvement of the pineal gland

Sudhakumari, C.C.; Haldar, Chandana; Senthilkumaran, B.

doi:10.1016/s1096-4959(01)00302-5

Cited by 29 publications

(15 citation statements)

References 34 publications

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“…1a) reflecting that birds were healthy without any severe infection in lungs. Testicular size was maximum during summer as reported earlier (Sudhakumari et al, 2001) for this bird which is a long day breeder. Furthermore fig.…”

Section: Discussionsupporting

confidence: 80%

“…For plasma melatonin, radioimmunoassay was done following the modified method of Rollag and Niswender (1976) as published by Singh and Haldar (2007a, b) and RIA kit from Immunochemical Corporation, Carson, USA was used for plasma testosterone assay. The validation of RIA was performed as described earlier (Sudhakumari et al, 2001). The sensitivity for melatonin RIA was 18-20 ng/ml and for testosterone RIA was 6 ng/ml.…”

Section: Hormonal Analysismentioning

confidence: 99%

“…Many studies have been performed regarding reproductive aspects of this and other bird species (Haldar and Ghosh, 1990;Sudhakumari et al, 2001;Goymann et al, 2006) and seasonal immunity (Singh and Haldar, 2006). In north India at the vicinity of Varanasi (lat.…”

Section: Introductionmentioning

confidence: 99%

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Annual variation in lung associated immunity and season dependent invasion of Alternaria alternata in lungs of Indian jungle bush quail, Perdicula asiatica

Haldar

2012

Animal Biol

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The purpose of this study was to evaluate annual variation in lung associated immune system (LAIS) along with general immunity ofPerdiculaasiaticaan Indian tropical bird. Variation in immunological parameters such as size of bronchus associated lymphoid tissue (BALT) and non-BALT nodules, percent stimulation ratio (%SR) of isolated lung lymphocytes, total leukocyte count (TLC) and lymphocyte count (LC) was noted along with circulatory hormonal levels i.e. melatonin and testosterone for two consecutive years. Lowest immune status in terms of small BALT and non-BALT nodular size, %SR, TLC and LC was noted in the month of April. Considering the relation between annual variation of the peripheral hormones melatonin and testosterone and immune status of this bird, we observed an inverse relationship. It could be that high testosterone (an immunosuppressor) and low melatonin (an immunostimulator) levels during summer months are responsible for low immunity. While studying annual variation in LAIS we observed a fungal pathogenAlternaria alternatapresent in the lungs only during April suggesting that invasion occurred at a particular month of harvest (April). During the month of April low lung immune status was recorded, which could be responsible for such an invasion. This bird is a game bird and consumed as food by common rural people. If this fungus is being ingested along with the birds it may cause diseases like bronchitis, asthma, etc. in human being. Hence, gaming of this bird during summer month (April) should be avoided.

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Section: Discussionsupporting

confidence: 80%

Section: Hormonal Analysismentioning

confidence: 99%

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Annual variation in lung associated immunity and season dependent invasion of Alternaria alternata in lungs of Indian jungle bush quail, Perdicula asiatica

Haldar

2012

Animal Biol

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“…Sudhakumari et al. [15] reported that plasma melatonin levels are inversely related to the levels of lipids (phospholipids, free and esterified cholesterol) and corticosterone. It was observed that the elevated levels of TG and LDL‐C in diabetic subjects are related to the oxidative susceptibility of lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

“…These data are consistent with those reported by El-Hendy et al [14], where cholesterol, TG and LDL-C were found to be increased in the serum of zinc-deficient rats. Sudhakumari et al [15] reported that plasma melatonin levels are inversely related to the levels of lipids (phospholipids, free and esterified cholesterol) and corticosterone. It was observed that the elevated levels of TG and LDL-C in diabetic subjects are related to the oxidative susceptibility of lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin

et al. 2006

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Glycemic control and prevention of secondary complications are the most important goals of using pharmacologic treatment of diabetes mellitus (DM). The inadequate responses to oral hypoglycemic agents may be attributed to inadequate postreceptor events even when insulin levels are quite sufficient, and associated with oxidative stress induced by long-term hyperglycemia. The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin, which act through this pathway. This project was designed to evaluate the effects of melatonin and zinc on the lipid profile and renal function in type 2 DM patients poorly controlled with metformin. A placebo-controlled, double-blind clinical trial was performed in which 46 type 2 diabetic patients were selected and allocated into three groups. These groups were treated with single daily oral doses of both 10 mg of melatonin and 50 mg of zinc acetate alone: 10 mg of melatonin and 50 mg of zinc acetate in addition to the regularly used metformin or placebo, given at bedtime for 90 days. Fasting lipid profiles and microalbuminuria (MAU) were measured before initiating the treatments (zero time) and after 30 and 90 days of treatment. Daily administration of melatonin and zinc improved the impaired lipid profile and decreased the level of MAU; the addition of this treatment regimen in combination with metformin improved the tissue responses to this oral hypoglycemic agent. In conclusion, the combination of melatonin and zinc acetate, when used alone or in combination with metformin, improves DM-related complications such as the impaired lipid profile and MAU in type 2 DM patients.

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Role of Pineal Gland in Relieving Environmental Stress

Sejian

Bahadur

Bharti

et al. 2012

Environmental Stress and Amelioration in Livestock Production

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Seasonal changes in adrenal and gonadal activity in the quail, Perdicula asiatica: involvement of the pineal gland

Cited by 29 publications

References 34 publications

Annual variation in lung associated immunity and season dependent invasion of Alternaria alternata in lungs of Indian jungle bush quail, Perdicula asiatica

Annual variation in lung associated immunity and season dependent invasion of Alternaria alternata in lungs of Indian jungle bush quail, Perdicula asiatica

Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin

Role of Pineal Gland in Relieving Environmental Stress

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