Plasma concentrations of insulin-like growth factor, triiodothyronine, thyroxine, and insulin in cows during different physiological states

Simonov, M. R.; Влизло, В. В.; Petruh, I. M.

doi:10.15407/agrisp3.03.017

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Specifically, a positive correlation has been found between the IGF-1 levels in bovine blood and milk [20]. In turn, the IGF-1 level in the blood depends on the levels of other hormones, which are correlated with the former one [21]. Along with other hormones, IGF-1 is involved in the formation of lactation dominance and contributes to overcoming the energy deficit, which is inherent to ruminants at the beginning of lactation [22,23].…”

Section: Discussionmentioning

confidence: 97%

Levels of insulin-like growth factor in bovine, goat, and sheep milk in different lactation periods: The etiological factor of cancer in humans

et al. 2021

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Background and Aim: Despite the positive aspects of consuming dairy products, there are also some reservations. Recently, a large number of publications have demonstrated convincing evidence of a relationship between the intake of dairy products and the development of cancer in humans. This study aimed to determine the level of insulin-like growth factor [IGF], which can cause cancer in consumers, in the milk of farm animals (cows, goats, and sheep) obtained at different stages of lactation. Materials and Methods: Enzyme-linked immunosorbent assay and statistical method were used for data processing. The IGF level in milk was determined using an enzyme-linked immunosorbent assay. Milk was collected from cows of Holstein and Ukrainian Black-and-White dairy breed, goats of Alpine and Saanen breed, and sheep of Tsigai and East Friesian breed. Milk samples in cows were collected at the beginning, on the peak, and at the end of lactation. Results: The obtained results showed that the highest IGF level was detected in milk obtained at the beginning of lactation, but its level depended on the animal species. More specifically, the highest level of the hormone was typical for goat's milk and for cow's milk of Holstein breed. Slightly lower values were revealed in the milk of cows of Black-and-White Ukrainian breed and sheep. During lactation, the absolute content of IGF in the milk of all studied animal species decreased. It should be noted that the most pronounced decrease in the IGF level in milk during lactation was noted in sheep (25-40 times), and minor changes were observed in goats (12-14 times). The results also showed that there were individual variations in the IGF level in milk in farm animals. Conclusion: The highest IGF level was noted in goat's milk, and the lowest level was observed in sheep's milk. Cow's milk, in this regard, had an intermediate IGF level. The level of this particular hormone depends on the period of lactation and the individual characteristics of the animal. It is advisable to include IGF as one of the assessment factors of dairy products' safety because this hormone can cause cancer in consumers of milk and dairy products.

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Section: Discussionmentioning

confidence: 97%

Levels of insulin-like growth factor in bovine, goat, and sheep milk in different lactation periods: The etiological factor of cancer in humans

et al. 2021

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“…У частини хворих корів одночасно діагностували пододерматит, мастит, ендометрит. Враховуючи те, що симптоми ураження печінки є загальними, а типові симптоми діагностуються в поодиноких випадках, тому для встановлення її патології важливим є проведення лабораторних досліджень крові (Kalaitzakis et al, 2010;Simonov & Vlizlo, 2015).…”

Section: результати та їх обговоренняunclassified

“…3). Печінка є основним органом, який забезпечує сталу концентрацію глюкози в крові завдяки процесам синтезу і розпаду глікогену та гліконеогенезу (Simonov et al, 2016). Встановлена нами гіпоглікемія у хворих на жирову гепатодистрофію корів сприяє активізації глікогенезу і утворення глюкози з глікогену печінки і м'язів.…”

Section: рис 2 вміст сечовини у сироватці крові корівunclassified

Protein-synthesizing, bile-forming, urea-forming and carbohydrate functions in cows with fatty degeneration of the liver

et al. 2021

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In dairy farms of Ukraine, where highly productive dairy cows are kept, liver lesions are often diagnosed in the postpartum period. Postmortem studies of the liver of cows that were forcibly slaughtered showed that in mostly animals were diagnosed with fatty degeneration of the liver. The main causes of fatty hepatosis were violations of the structure of rations, imbalance of feeding on essential nutrients and biologically active substances, low content of easily digestible carbohydrates and high protein content. The study was performed on cows aged 4–5 years with productivity for the previous lactation of 5.600–7.500 L of milk, in a winter-stall period of keeping, 2–3 weeks after calving. According to clinical and biochemical blood tests, two groups of cows were formed – 50 clinically healthy and 50 cows with fatty liver disease. In cows diagnosed with fatty liver degeneration, the disease was manifested by decreased productivity and fatness, loss of appetite, oppression, hypotony of the rumen, reticulum and omasum. In some cows, there was pain at the liver area, increasing boundaries of hepatic dullness, jaundice of the visible mucous membranes and sclera. The blood serum of all cows with fatty liver disease established a decrease in albumin content, indicating impaired protein synthesis function of the liver. In some cows, the content of total protein in the serum increased due to globulin fractions, mainly gamma globulins. The ratio between the content of albumins and globulins decreased, which indicates the development in the blood of sick animals dysproteinemia. The development of fatty infiltration of the liver caused an increase in the concentration of bile acids in the serum of all sick cows. This is due to reduced conjugation and excretion of cholates by affected hepatocytes from the bile capillaries. The formation, absorption, conjugation, and excretion of bilirubin in the bile is disturbed, which causes the accumulation of total and conjugated bilirubin in the serum of sick animals. The cholesterol content in the blood of cows decreased, caused a violation of the esterification of its esters by hepatocytes. The established changes in the content of bile acids, total and conjugated bilirubin, and cholesterol in the blood of sick cows indicate a violation of bile secretion, bile production, and cholestasis development. In some cows with fatty liver degeneration, urea formation function and carbohydrate function are impaired, leading to a decrease in blood urea content and glucose.

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Plasma concentrations of insulin-like growth factor, triiodothyronine, thyroxine, and insulin in cows during different physiological states

Cited by 2 publications

References 17 publications

Levels of insulin-like growth factor in bovine, goat, and sheep milk in different lactation periods: The etiological factor of cancer in humans

Levels of insulin-like growth factor in bovine, goat, and sheep milk in different lactation periods: The etiological factor of cancer in humans

Protein-synthesizing, bile-forming, urea-forming and carbohydrate functions in cows with fatty degeneration of the liver

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