Plasma Catecholamine Levels in Preterm Infants

Greenough, Anne; Lagercrantz, Hugo; Pool, J; Dahlin, Ingrid

doi:10.1111/j.1651-2227.1987.tb10414.x

Cited by 103 publications

(29 citation statements)

References 8 publications

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“…One possible explanation to this finding is that these infants had lower gestational age and did not respond to the catecholamine surge to the same extent as the other infants in agreement with a study particularly on catecholamine levels in preterm infants [2],…”

Section: Discussionsupporting

confidence: 73%

Fetal catecholamines and the Apgar score

Nylund¹,

Dahlin²,

Lagercrantz³

1987

Journal of Perinatal Medicine

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Section: Discussionsupporting

confidence: 73%

Fetal catecholamines and the Apgar score

Nylund¹,

Dahlin²,

Lagercrantz³

1987

Journal of Perinatal Medicine

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“…The increase in neonatal testosterone due to birth hypoxia contrasts with the effects of many other manipulations, including neonatal cooling or anesthesia and maternal exposure to repeated hypoxia, stress, alcohol or toxins during pregnancy, which have been reported to decrease neonatal testosterone [9,10,11,12,13]. Birth hypoxia has been shown to be associated with alterations in levels of a wide variety of circulating hormones [15,16,17,18,19]. These acute hormonal alterations may be pathological, protective or without effect.…”

Section: Discussionmentioning

confidence: 99%

“…Birth hypoxia in humans and in rat models is known to be associated with alterations in a number of circulating hormones, including catecholamines, glucocorticoids, thyroid hormones, endorphin, and others [15,16,17,18,19]. However, it is unknown whether birth hypoxia affects levels of neonatal testosterone.…”

Section: Introductionmentioning

confidence: 99%

Global Birth Hypoxia Increases the Neonatal Testosterone Surge in the Rat

Boksa

Zhang

2008

Neuroendocrinology

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Background/Aims: Global birth hypoxia in rats has been shown to produce long-term changes in central nervous system functions, known to be influenced by neonatal testosterone secretion. Birth hypoxia alters levels of several circulating hormones, but it is unknown if it affects neonatal testosterone. Methods: Using a rat model of acute global hypoxia during cesarean section (C-section) birth, this study tested whether birth hypoxia affects neonatal testosterone. We then evaluated whether the observed hypoxia-induced changes in neonatal testosterone may be mediated via N-methyl-D-aspartate (NMDA) receptor activation and/or altered luteinizing hormone (LH), adrenocorticotropic hormone (ACTH) or corticosterone levels. Longer-term effects of birth hypoxia on testosterone-related function were also assessed. Results: Rats born by C-section + 15 min of anoxia had significantly higher plasma testosterone at 2 and 3 h after birth compared to controls born either vaginally or by C-section. Administration of an NMDA receptor antagonist at birth increased neonatal testosterone in both anoxic pups and controls. Pups exposed to birth anoxia under hypothermic conditions also showed increased neonatal testosterone. Circulating LH, follicle-stimulating hormone and corticosterone in neonates, and testosterone at adulthood were unaffected by birth hypoxia. However, plasma ACTH was significantly increased in anoxic neonates at 2 h after birth. Birth condition had no effect on anogenital distance or juvenile play behavior. Conclusion: It is concluded that birth hypoxia augments plasma testosterone during the critical period of the neonatal testosterone surge, by a mechanism that is independent of NMDA-mediated LH secretion, but may involve increased circulating ACTH.

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“…footnote). In these patients, blood pressure [mean (range)] was 69 mm Hg (47-94) systolic and 43 mm Hg (24-79) diastolic, heart rate was 145 bpm (80-170), arterial pH was 7.4 (7.32-7.57), Poz was 68 mm Hg (54-107) [9][10][11][12][13][14]], and PCO? was 40 mm Hg (24-54) [5][6][7]].…”

Section: Resultsmentioning

confidence: 99%

Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

et al. 1992

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ABSTRACT. In this study, we investigated whether cap-procedures can have ethical and practical limitations, particularly illary plasma catecholamines can be used as a suitable in healthy infants. The aim of this study was to investigate substitute for arterial catecholamines. Analysis was done whether the use of capillary plasma CAT can be an alternative. radioenzymatically. Catecholamine concentrations were not different in arterial and simultaneously collected "ar- Group 1. For comparison of "arterialized" capillary with arteHowever, "arterialization" of capillary blood is important; rial CAT concentrations, two blood samples were taken simulwhen blood was obtained in nine neonates without warming taneously by heel prick from the hyperemic (warmed) foot and their feet, capillary concentrations of noradrenaline were from an indwelling umbilical arterial catheter in 18 infants (five higher than arterial values (p < 0.03) and those of adren-girls, 13 boys) between d 1 and 14 (mean 5.5 d) after birth aline were not different from arterial values. Catecholamine (average gestational age, 35 wk). Their birth weights ranged from concentrations in arterialized capillary plasma collected in 1240 to 4230 g (mean, 2423 g); five were full-term and 13 were healthy full-term infants at 1 h [n = 9; noradrenaline: 6.85 preterm babies. well-known fall ( p < 0.01) in catecholamine levels after from an indwelling umbilical arterial catheter in nine infants delivery. With a highly sensitive analytical technique, cate-(four girls, five boys) between d 1 and 13 (mean 3.3 d) after birth cholamine concentrations can reliably be assessed in mi-(average gestational age, 35 wk); their birth weights ranged from nute samples (100-200 pL) of arterialized capillary blood, 980 to 4730 g (mean, 238 1 g); three were full-term and six were even when concentrations have dropped to low "resting" preterm babies. basal levels. Moreover, the capillary sampling procedure Healthy neonates. Arterialized capillary blood (warmed foot) is simple and safe, can easily be applied to healthy infants, was obtained by heel prick from two groups of apparently and does not have the practical and ethical limitations of healthy, full-term infants, when capillary puncture was done for arterial blood sampling. (Pediatr Res 31: 579-582, 1992) routine medical purposes. All 27 newborns had uneventful neonatal periods; birth weights were 3334 + 294 g (mean +. SD). AbbreviationsTwo groups were studied. Group 3. Eighteen infants (nine girls, nine boys) were studied CAT, catecholamine on approximately their 5th d of life. A, adrenaline Group 4. Nine infants (two girls, seven boys) born during the NA, noradrenaline daytime by uncomplicated deliveries (five vaginally and four by cesarean section) with Apgar scores of 10 at 10 min were studied at 1 h after birth and approximately d 5 (4-6) after birth. The study protocols had been approved by the ethical comPlasma CAT are successfully used to study the stressful peri-mittee of the medical faculty and parental consent was obtain...

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Plasma Catecholamine Levels in Preterm Infants

Cited by 103 publications

References 8 publications

Fetal catecholamines and the Apgar score

Fetal catecholamines and the Apgar score

Global Birth Hypoxia Increases the Neonatal Testosterone Surge in the Rat

Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

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