ABSTRACT. In this study, we investigated whether cap-procedures can have ethical and practical limitations, particularly illary plasma catecholamines can be used as a suitable in healthy infants. The aim of this study was to investigate substitute for arterial catecholamines. Analysis was done whether the use of capillary plasma CAT can be an alternative. radioenzymatically. Catecholamine concentrations were not different in arterial and simultaneously collected "ar- Group 1. For comparison of "arterialized" capillary with arteHowever, "arterialization" of capillary blood is important; rial CAT concentrations, two blood samples were taken simulwhen blood was obtained in nine neonates without warming taneously by heel prick from the hyperemic (warmed) foot and their feet, capillary concentrations of noradrenaline were from an indwelling umbilical arterial catheter in 18 infants (five higher than arterial values (p < 0.03) and those of adren-girls, 13 boys) between d 1 and 14 (mean 5.5 d) after birth aline were not different from arterial values. Catecholamine (average gestational age, 35 wk). Their birth weights ranged from concentrations in arterialized capillary plasma collected in 1240 to 4230 g (mean, 2423 g); five were full-term and 13 were healthy full-term infants at 1 h [n = 9; noradrenaline: 6.85 preterm babies. well-known fall ( p < 0.01) in catecholamine levels after from an indwelling umbilical arterial catheter in nine infants delivery. With a highly sensitive analytical technique, cate-(four girls, five boys) between d 1 and 13 (mean 3.3 d) after birth cholamine concentrations can reliably be assessed in mi-(average gestational age, 35 wk); their birth weights ranged from nute samples (100-200 pL) of arterialized capillary blood, 980 to 4730 g (mean, 238 1 g); three were full-term and six were even when concentrations have dropped to low "resting" preterm babies. basal levels. Moreover, the capillary sampling procedure Healthy neonates. Arterialized capillary blood (warmed foot) is simple and safe, can easily be applied to healthy infants, was obtained by heel prick from two groups of apparently and does not have the practical and ethical limitations of healthy, full-term infants, when capillary puncture was done for arterial blood sampling. (Pediatr Res 31: 579-582, 1992) routine medical purposes. All 27 newborns had uneventful neonatal periods; birth weights were 3334 + 294 g (mean +. SD). AbbreviationsTwo groups were studied. Group 3. Eighteen infants (nine girls, nine boys) were studied CAT, catecholamine on approximately their 5th d of life. A, adrenaline Group 4. Nine infants (two girls, seven boys) born during the NA, noradrenaline daytime by uncomplicated deliveries (five vaginally and four by cesarean section) with Apgar scores of 10 at 10 min were studied at 1 h after birth and approximately d 5 (4-6) after birth. The study protocols had been approved by the ethical comPlasma CAT are successfully used to study the stressful peri-mittee of the medical faculty and parental consent was obtain...
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