Fetal catecholamines and the Apgar score

Nylund, L.; Dahlin, Ingrid; Lagercrantz, Hugo

doi:10.1515/jpme.1987.15.4.340

Cited by 14 publications

(6 citation statements)

References 8 publications

(9 reference statements)

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“…In contrast to the studies of GREENOUGH et al [7], PUOLAKKA et al [22], NEWNHAM et al [12], and NYLUND et al [13], we observed a significant correlation between free adrenaline and gestational age, birth length and birth weight. GRA-DERT et al [6] noticed a significant correlation between free adrenaline and the birth weight only.…”

Section: Discussioncontrasting

confidence: 99%

“…An immaturity of pH-and pCO 2 -sensors of preterm neonates may contribute to their inappropriate secretion. Several investigators [7,9,13,26] showed similar results comparing catecholamine levels with the arterial pH and APGAR (l min). The inappropriate catecholamine secretion in preterm neonates is important for their postnatal adaptation to extra-uterine life leading to a higher incidence of hypoglycaemia and hypothermia as well as to wet lungs and respiratory distress syndromes in preterm compared to term neonates.…”

Section: Discussionmentioning

confidence: 68%

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Inappropriate secretion of umbilical plasma catecholamines in preterm compared to term neonates

Schwab¹,

Breitung²,

Stockhausen³

1996

Jpme

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To investigate the gestation and stimulus related catecholamine secretion and degradation at birth free and sulfoconjugated adrenaline, noradrenaline and dopamine were analysed in the umbilical artery and vein of 35 preterm and 75 term neonates. A highly sensitive radioenzymatic assay was used for the determination of free catecholamine levels, sulfoconjugated catecholamines were analysed after addition of 25 mU arylsulfatase type VI. Levels of free catecholamines were significantly lower in preterm as compared to term newborns. Hereby, adrenaline levels significantly correlated with the gestational age, birth weight, and birth length. Sulfoconjugated catecholamine levels were similarly lower, but only sulfoconjugated noradrenaline reached differences of statistical significance. The placental extraction rate of adrenaline and noradrenaline was significantly lower in preterm as compared to term neonates. Only in term but not in preterm neonates, arterial pH- and pCO2-levels significantly correlated with arterial plasma catecholamine levels. Therefore, lower catecholamine levels in preterm compared to term neonates result from lower secretion of catecholamines rather than increased degradation and may contribute to their frequent surfactant deficiency. In addition, the inadequate and diminished catecholamine secretion of preterm neonates may play a significant part in their postnatal adaptation problems like hypoglycaemia, hypothermia and occurrence of wet lungs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 68%

Inappropriate secretion of umbilical plasma catecholamines in preterm compared to term neonates

Schwab¹,

Breitung²,

Stockhausen³

1996

Jpme

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“…Previous studies have demonstrated a significant correlation between catecholamine levels and umbilical cord base status [3,24,27]. A similar relationship was observed in this study.…”

Section: Discussionsupporting

confidence: 91%

“…The elevated catecholamine levels observed in the infants with MSAF in this study are comparable to those previously reported following complicated deliveries without MSAF [3,10,24,28]. Previous studies have demonstrated a significant correlation between catecholamine levels and umbilical cord base status [3,24,27].…”

Section: Discussionsupporting

confidence: 88%

Catecholamine levels and associated cardiovascular responses in infants with meconium-stained amniotic fluid

1992

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Catecholamine levels and associated cardiovascular responses were determined in 21 control and 30 term infants with meconium-stained amniotic fluid (MSAF). Cord arterial blood was obtained for determination for norepinephrine (NE) and epinephrine (EPI) levels; cardiovascular measurements included heart rate and systolic blood pressure at 30 min. Pregnancy was uncomplicated in all cases. The total length of labor 964 +/- 402 versus 555 +/- 312 min (P < 0.001) and active phase of labor 300 +/- 261 versus 135 +/- 104 min (P < 0.001) were significantly longer in MSAF infants when compared to controls. The 1 min Apgar score was < 7 (range 1-6) in 11 of 30 MSAF infants versus 0 of 21 control infants; these 11 infants required positive pressure ventilation for approximately 60 s secondary to transient respiratory depression (RD). The 5 min Apgar score was > 7 in 49 of the 51 infants. Infants with MSAF exhibited a higher PaCO2 (6.89 +/- 1.17 vs 6.24 +/- 1.17 mmHg; P < 0.02) and lower pH (7.25 +/- 0.06 vs 7.29 +/- 0.05; P < 0.02) compared to controls. Infants with transient RD demonstrated the most marked arterial blood gas differences, i.e., PCO2 7.41 +/- 1.30 mmHg (P < 0.001), pH 7.21 +/- 0.07 (P < 0.001) and base deficit -6 +/- 4 versus -3 +/- 2.8 (P < 0.001) when compared to controls. NE and EPI levels were significantly higher in MSAF versus control infants, i.e., 12600 +/- 3040 versus 3740 +/- 1000 pg/ml (SEM) (P < 0.02) and 1550 +/- 250 versus 620 +/- 130 pg/ml (P < 0.001) respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…This study is thus in good agreement with the findings of Sykes et al [20], who established that 73% of infants with severe acidosis had Apgar score > 7. The rise in catecholamines in the hyp oxic fetus has been suggested as an explanation for this [4,[21][22][23]. The catecholamines increase every compo nent of the apgar score except skin colour.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Beta-2-Adrenoceptors and Plasma Catecholamines in Fetal Hypoxia

Santala

Saarikoski²,

Castrén³

et al. 1990

Gynecol Obstet Invest

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Conclusive evidence has been furnished that the Β₂-adrenoceptor density in circulating lymphocytes is related to that of Β₂-adrenoceptors in tissues from the same subjects. This study was designed to evaluate the effect of fetal hypoxia on lymphocyte Β₂-adrenoceptor density. The material consisted of 8 hypoxic newborns, 4 delivered by vacuum extraction and 4 by Caesarean section, after approximately 10 h parturition. The control group consisted of 8 vaginally delivered newborns without hypoxia. Umbilical plasma adrenaline and noradrenaline were significantly elevated in the hypoxic newborns. Their lymphocyte Β₂-adrenoceptor density was lower (p < 0.01) than that in the controls. A plausible explanation for this finding might be downregulation of Β₂-adrenoceptors because of elevated plasma catecholamine level.

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Fetal catecholamines and the Apgar score

Cited by 14 publications

References 8 publications

Inappropriate secretion of umbilical plasma catecholamines in preterm compared to term neonates

Inappropriate secretion of umbilical plasma catecholamines in preterm compared to term neonates

Catecholamine levels and associated cardiovascular responses in infants with meconium-stained amniotic fluid

Lymphocyte Beta-2-Adrenoceptors and Plasma Catecholamines in Fetal Hypoxia

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