1982
DOI: 10.1016/s0140-6736(82)90182-9
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Plasma Caffeine Concentrations in Outpatients

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Cited by 45 publications
(15 citation statements)
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“…In our pregnant rats, 0.04 and 0.02% caffeine intakes were calculated to correspond approximately to less than 50 and 25 mg caffcine/kg body weight/day, re spectively, because the consumed volume measurements were rough [5,6], When the maternal and fetal caffeine levels in the morning on gestational day 21 in the present study were compared with those in the eve ning on gestational day 20 in the previous study [5], it was considered that these levels were maintained at least during middle to late pregnancy. Therefore, an adverse effect of maternal caffeine on the fetal cerebrum is possible with a level of 1.5-3.0 jig caffeine/ml in maternal plasma, this concentra tion coinciding with that found on random plasma caffeine measurement in 600 adult outpatients [10].…”
Section: Discussionsupporting
confidence: 72%
“…In our pregnant rats, 0.04 and 0.02% caffeine intakes were calculated to correspond approximately to less than 50 and 25 mg caffcine/kg body weight/day, re spectively, because the consumed volume measurements were rough [5,6], When the maternal and fetal caffeine levels in the morning on gestational day 21 in the present study were compared with those in the eve ning on gestational day 20 in the previous study [5], it was considered that these levels were maintained at least during middle to late pregnancy. Therefore, an adverse effect of maternal caffeine on the fetal cerebrum is possible with a level of 1.5-3.0 jig caffeine/ml in maternal plasma, this concentra tion coinciding with that found on random plasma caffeine measurement in 600 adult outpatients [10].…”
Section: Discussionsupporting
confidence: 72%
“…It is also interesting that caffeine is detected in habitual caffeine-consuming humans at concentrations capable of antagonizing A2AR, 10 -50 M in moderate to heavy caffeine consumers (43,44). Other studies showed that when humans acutely ingested 2-2.5 mg/kg caffeine (corresponding to the amount in two cups of coffee), blood caffeine concentration was ϳ20 M (41,45,46). In contrast, amounts of caffeine much higher than what people usually consume will be required for the immunosuppressive effects of caffeine.…”
Section: Discussionmentioning
confidence: 99%
“…Only one other study has evaluated caffeine plasma concentration in a naturalistic setting. In that study, general medical outpatients were found to have caffeine concentrations between 0.2 and 13.1 mg/l, with a mean of 2.1 mg/l (Smith et al, 1982).…”
Section: Introductionmentioning
confidence: 93%