Effects of Maternal Caffeine Ingestion on the Perinatal Cerebrum

Tanaka, Harumi; Nakazawa, Kazuharu; Arima, Masataka

doi:10.1159/000242672

Cited by 17 publications

(9 citation statements)

References 13 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the 24 h after birth, in the C-C group, which showed a high caffeine concen tration in the cerebrum in this study. This result may support that in previous studies reduced fetal cerebral weight was found to be associated with a high caffeine level in the cerebrum [2,4], In adult rats a caffeine level of 20-30 pg/ml in the plasma or per gram in the brain provokes automutilating behavior sim ilar to that observed in Lesch-Nyhan syn drome [13] and results in remarkable de creases in the plasma levels of tyroxine and tri-iodothyronine, and of their precursors, phenylalanine and tyrosine [14], Further more, a significant reduction in the free tyro sine level in the cerebral cortex has been reported [15], However, there have been no studies on the amino acid levels in offspring exposed to caffeine in utero. Unexpectedly, our present study showed a significantly high tyrosine but not a high phenylalanine level in the cerebrum with low caffeine levels of 1.5-2.0 pg/g wet weight on days 1-5.…”

Section: Discussionsupporting

confidence: 92%

“…In addition to the fetal period examined in our previous studies [1][2][3][4], this investiga tion was an attempt to clarify the effect of maternal caffeine on the neonatal cerebrum during the period of days 1-10 postpartum, which are taken to correspond to the third trimester in human pregnancy. Reduced fe tal cerebral weight [1,2,4] also continued on day 1, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of three modes of maternal oral ingestion for dams were about the same as described previously [2][3][4], The litter size was 11 ± 4 [8] in the W-W, 11 ± 2 [9] in the W-C and 11 ± 3 [11] in the C-C group, respectively (means ± SD [no of dams]). The mean body, cerebrum and liver weights of the neonatal offspring are shown in ta ble 1.…”

Section: Maternal and Neonatal Factorsmentioning

confidence: 99%

“…The possible harmful effect of caffeine in human pregnancy cannot be neglected be cause of the pharmacological and embryofetopathic action of caffeine or its dimethylxanthines under experimental conditions [1][2][3][4], In a previous study we demonstrated the adverse effect of maternal caffeine inges tion on the fetal cerebrum in the rat, which may be associated with the decreased appar ent volume of distribution of caffeine in the maternal plasma and the high caffeine con tent of the fetal cerebrum [1][2][3]. Further more, low caffeine levels of 1.5-3.0 pg caf feine per ml or g wet weight, in mothers and fetuses, lowered the cerebral weight [4], In the present study the effect of maternal caf feine on the levels of free amino acids and one metabolite of catecholamine degrada tion in the neonatal cerebrum was examined to elucidate the factors related to cerebral …”

mentioning

confidence: 99%

See 3 more Smart Citations

Maternal Caffeine Ingestion Increases the Tyrosine Level in Neonatal Rat Cerebrum

Tanaka

Nakazawa²

1990

Neonatology

Self Cite

View full text Add to dashboard Cite

The cerebral free amino acids in neonatal rats, from dams given 0.04% caffeine in the drinking fluid ad libitum before and/or during pregnancy throughout the lactational period, were examined on days 1, 5 and 10. Significantly reduced cerebral weight was observed on day 1 with a mean caffeine level of 7 μg/g wet weight. The tyrosine concentration in the cerebrum, but not that in the liver, was increased on days 1 and 5 with approximate mean caffeine levels of above 1.5–2.0 μg/g wet weight. The tyrosine level showed a positive correlation with the caffeine level in neonatal cerebrum only on day 1 in the group with caffeine ingestion after pregnancy. There was no significant increase in the fetal cerebral concentration of MOPEG-SO₄ on day 5 with maternal caffeine. These results suggest that maternal caffeine disturbs the neonatal cerebrum through tyrosine and tyrosine hydroxylase, and then produces behavioral abnormalities in developing rats.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Maternal and Neonatal Factorsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Maternal Caffeine Ingestion Increases the Tyrosine Level in Neonatal Rat Cerebrum

Tanaka

Nakazawa²

1990

Neonatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neurodevelopment is not entirely controlled by spatiotemporal gene expression, but also by the external environment of the embryo, which induces the greatest influence during cranial neural crest cell delamination. Previous studies have shown that caffeine can transfer into the embryo from the external environment [9] and accumulate in the fetal brain [10], [11]. Therefore, it is conceivable that maternal ingestion of caffeine can disrupt the normal processes of neurodevelopment; hence caffeine can act as a teratogen.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Caffeine-Induced Teratogenicity on Neurodevelopment Using Early Chick Embryo

Yang

Wang

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

Caffeine consumption is worldwide. It has been part of our diet for many centuries; indwelled in our foods, drinks, and medicines. It is often perceived as a “legal drug”, and though it is known to have detrimental effects on our health, more specifically, disrupt the normal fetal development following excessive maternal intake, much ambiguity still surrounds the precise mechanisms and consequences of caffeine-induced toxicity. Here, we employed early chick embryos as a developmental model to assess the effects of caffeine on the development of the fetal nervous system. We found that administration of caffeine led to defective neural tube closures and expression of several abnormal morphological phenotypes, which included thickening of the cephalic mesenchymal tissues and scattering of somites. Immunocytochemistry of caffeine-treated embryos using neural crest cell markers also demonstrated uncharacteristic features; HNK1 labeled migratory crest cells exhibited an incontinuous dorsal-ventral migration trajectory, though Pax7 positive cells of the caffeine-treated groups were comparatively similar to the control. Furthermore, the number of neurons expressing neurofilament and the degree of neuronal branching were both significantly reduced following caffeine administration. The extent of these effects was dose-dependent. In conclusion, caffeine exposure can result in malformations of the neural tube and induce other teratogenic effects on neurodevelopment, although the exact mechanism of these effects requires further investigation.

show abstract

Epileptogenic action of caffeine during anoxia in the neonatal rat hippocampus

et al. 1999

View full text Add to dashboard Cite

Excessive maternal caffeine consumption can lead to fetal and neonatal pathology, but the underlying mechanisms have not been determined. Here, we report that low doses of caffeine generate seizures when applied in conjunction with brief anoxic episodes in the hippocampus of neonatal rats in vitro. In control conditions, brief (4–6 minutes) anoxic episodes reversibly depressed evoked synaptic responses and blocked the physiological pattern of network activity. In the presence of caffeine (50 μM), similar anoxic episodes generated ictal (29%) or interictal (33%) epileptiform activities often followed during reoxygenation by recurrent spontaneous seizure activity that persisted for several hours. These effects are likely mediated by a blockade of adenosine receptors by caffeine because (1) in control conditions, caffeine antagonized the inhibitory effect of selective A1 receptor agonist N6‐cyclopentyladenosine on excitatory synaptic responses, and (2) epileptogenic effects of caffeine were reproduced by selective A1 receptor antagonist 8‐cyclopentyl‐1,3‐dipropylxanthine and theophylline. Our findings suggest that endogenous adenosine released during anoxia acting via A1 receptors prevents seizures in the neonatal hippocampus and that the antagonism of these receptors by caffeine leads to epileptogenesis. This study suggests concerns about the safety of caffeine in the fetus and newborn. Ann Neurol 1999;46:95–102

show abstract

Effects of Maternal Caffeine Ingestion on the Perinatal Cerebrum

Cited by 17 publications

References 13 publications

Maternal Caffeine Ingestion Increases the Tyrosine Level in Neonatal Rat Cerebrum

Maternal Caffeine Ingestion Increases the Tyrosine Level in Neonatal Rat Cerebrum

Exploring the Caffeine-Induced Teratogenicity on Neurodevelopment Using Early Chick Embryo

Epileptogenic action of caffeine during anoxia in the neonatal rat hippocampus

Contact Info

Product

Resources

About