Plasma‐based ambient mass spectrometry: Recent progress and applications

Yue, Hanlu; He, Fang; Zhao, Zhongjun; Duan, Yixiang

doi:10.1002/mas.21712

Cited by 25 publications

(25 citation statements)

References 270 publications

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“…However, for nonpolar compounds, such as paraffin wax, MasSpec Pointer shows an overwhelming advantage for nanoESI. These results are consistent with previous reports that plasma-based ion sources are more suitable for nonpolar compounds than spray-based ion sources . Both MasSpec Pointer and LTP generate similar ion types, such as [M + H] + , [M + NH 4 ] + , and [M + O – 3H] + .…”

Section: Resultssupporting

confidence: 92%

“…The oxidation may result from the high concentration of reactive oxygen species (ROS) in the plasma generated from MasSpec Pointer. 27 The proposed mechanisms of the oxidations of caffeine 28 and citric acid are shown in Scheme S1. In addition, other compounds such as daily necessities and agrochemical can also be well determined using MasSpec Pointer in both modes (Figure S3).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…These results are consistent with previous reports that plasma-based ion sources are more suitable for nonpolar compounds than spray-based ion sources. 27 Both MasSpec Pointer and LTP generate similar ion types, such as [M + H] + , [M + NH 4 ] + , and [M + O − 3H] + . It seems that the signal intensity of the background ions of LTP is higher than that of MasSpec Pointer.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Interestingly, oxidation peaks of both caffeine and citric acid were found in the spectra. The oxidation may result from the high concentration of reactive oxygen species (ROS) in the plasma generated from MasSpec Pointer . The proposed mechanisms of the oxidations of caffeine and citric acid are shown in Scheme S1.…”

Section: Resultsmentioning

confidence: 99%

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Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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Current ambient ionization sources for mass spectrometry (MS) are typically connected to gas cylinders, high-voltage supply, injection pump, and other accessory equipment, which hinder the popularization of MS in the field of on-site detection. Here, we developed a wireless pocket-size "MasSpec Pointer" (weights 65 g) based on arc discharge powered by a 3.7 V polymer Li battery for ambient ionization MS. A high voltage of 5600 V and 20 kHz was generated from the boost coil to penetrate air and form a plasma. The relative standard deviation (RSD) of the high-voltage pulses is 3.8%, leading to a stable discharge and a good quantification performance. A mini diaphragm pump was used to cool the plasma from ∼600 to ∼40 °C and to blow the plasma into a jet, which facilitates sampling. MasSpec Pointer can work well at both positive-and negative-ion modes without any modification and can quickly test gaseous, liquid, or solid samples. The limit of detection of this device for atrazine (an agrochemical) is lower than 0.1 ng/mL. MasSpec Pointer has shown its ability to pinpoint the double-bond location of fatty acid isomers without derivatization reagents or light illumination. Agrochemicals from the surface of an apple and daily chemicals from the surface of a finger were detected successfully using MasSpec Pointer coupled with a miniature mass spectrometer. We believe the "point-and-shoot" device coupled with mini-MS brings the hope for an age of detecting chemicals on-site by nonprofessionals.

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Section: Resultssupporting

confidence: 92%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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“… 3 − 5 The nature of the discharge is influenced by different factors, but mostly the power supply (direct-current, alternative-current (AC), or microwave) and the selected discharge gas define the plasma discharge behavior. 6 , 7 The design versatility and the expanded chemical coverage granted by plasma-based ion sources, enabling ionization of both polar and low polar species, are one of their unique desirable features. 8 , 9 One of the more versatile and flexible approaches in plasma-based devices are those based on dielectric barrier discharges (DBDs).…”

Section: Introductionmentioning

confidence: 99%

Dielectric Barrier Discharge Ionization Mechanisms: Polycyclic Aromatic Hydrocarbons as a Case of Study

et al. 2022

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Dielectric barrier discharge ionization (DBDI) is a versatile tool for small-molecule mass spectrometry applications, helping cover from polar to low polar molecules. However, the plasma gas-phase interactions are highly complex and have been scarcely investigated. The ionization mechanisms of plasmas have long been assumed to be somewhat similar to atmospheric pressure chemical ionization (APCI). Here, we evaluated the ionization mechanisms of a two-ring DBDI ion source, using different discharge gases to analyze vaporized liquid samples. Polycyclic aromatic hydrocarbons (PAHs) were used as model analytes to assess the mechanisms' dominance: protonation, [M + H] + , or radical ion species formation, [M] •+ . In the present work, two different ionization trends were observed for APCI and DBDI during the PAH analysis; the compounds with proton affinities (PA) over 856 kJ/mol were detected as [M + H] + when APCI was used as ionization source. Meanwhile, independently of the PA, DBDI showed the prevalence of charge exchange reactions. The addition of dopants in the gas-phase region shifted the ionization mechanisms toward charge exchange reactions, facilitating the formation of [M] •+ ion species, showing anisole a significant boost of the PAH radical ion species signals, over nine times for Ar-Prop-DBDI analysis. The presence of high-energy metastable atoms (e.g., He M ) with high ionization potentials (IE = 19.80 eV) did not show boosted PAH abundances or extensive molecule fragmentation. Moreover, other species in the plasma jet region with closer and more appropriate IE, such as N 2 B 3 Π g excited molecules, are likely responsible for PAH Penning ionization.

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Synthetic dyes: A mass spectrometry approach and applications

Millbern

Trettin

et al. 2022

Mass Spectrometry Reviews

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Synthetic dyes are found in a wide variety of applications today, including but not limited to textiles, foods, and medicine. The analysis of these molecules is pertinent to several fields such as forensics, environmental monitoring, and quality control, all of which require the sensitivity and selectivity of analysis provided by mass spectrometry (MS). Recently, there has been an increase in the implementation of MS evaluation of synthetic dyes by various methods, with the majority of research thus far falling under electrospray ionization and moving toward direct ionization methods. This review covers an overview of the chemistry of synthetic dyes needed for the understanding of MS sample preparation and spectral results, current fields of application, ionization methods, and fragmentation trends and works that have been reported in recent years.

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Plasma‐based ambient mass spectrometry: Recent progress and applications

Cited by 25 publications

References 270 publications

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Dielectric Barrier Discharge Ionization Mechanisms: Polycyclic Aromatic Hydrocarbons as a Case of Study

Synthetic dyes: A mass spectrometry approach and applications

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