Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Li, Yuze; Chen, Junyu; Meng, Lingwei; He, Liuying; Liu, Huihui; Xiong, Chenyan; Nie, Zongxiu

doi:10.1021/acs.analchem.1c03087

Cited by 14 publications

(19 citation statements)

References 39 publications

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“…Thus, the energy barrier of epoxidation was lowered, and the rate constant was increased . As shown in Figure S6, two lipid isomers, oleic acid FA 18:1 (9Z) and cis-vaccenic acid FA 18:1 (11Z), were oxidized via BBIE, and the MS results were similar to the previous reports obtained using arc-induced and low-temperature plasma-induced epoxidations. , Therefore, the BBIE coupled with MS/MS can be used to distinguish UFA isomers.…”

Section: Resultssupporting

confidence: 81%

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Gao

Guo

et al. 2022

Anal. Chem.

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Aerosols generated by bubble bursting have been proved to promote the extraction of analytes and have ultrahigh electric fields at their water–air interfaces. This study presented a simple and efficient ionization method, carbon dioxide microbubble bursting ionization (CDMBI), without the presence of an exogenous electric field (namely, zero voltage), by simulating the interfacial chemistries of sea spray aerosols. In CDMBI, microbubbles are generated in situ by continuous input of carbon dioxide into an aqueous solution containing low-concentration analytes. The microbubbles extract low- and high-polarity analytes as they pass through the aqueous solution. Upon reaching the water–air interface, these microbubbles burst to produce charged aerosol microdroplets with an average diameter of 260 μm (8.1–10.4 nL in volume), which are immediately transferred to a mass spectrometer for the detection and identification of extracted analytes. The above analytical process occurs every 4.2 s with a stable total ion chromatogram (relative standard deviation: 9.4%) recorded. CDMBI mass spectrometry (CDMBI-MS) can detect surface-active organic compounds in aerosol microdroplets, such as perfluorooctanoic acid, free fatty acids epoxidized by bubble bursting, sterols, and lecithins in soybean and egg, with the limit of detection reaching the level of fg/mL. In addition, coupling CDMBI-MS with an exogenous voltage yields relatively weak gains in ionization efficiency and sensitivity of analysis. The results suggested that CDMBI can simultaneously accomplish both bubbling extraction and microbubble bursting ionization. The mechanism of CDMBI involves bubbling extraction, proton transfer, inlet ionization, and electrospray-like ionization. Overall, CDMBI-MS can work in both positive and negative ion modes without necessarily needing an exogenous high electric field for ionization and quickly detect trace surface-active analytes in aqueous solutions.

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Section: Resultssupporting

confidence: 81%

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Gao

Guo

et al. 2022

Anal. Chem.

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“…Figures depicting the design and appearance of the MasSpec Pointer (A‐D), the waveform of the pulsed high‐voltage of the device (E), and the use of use of the pointer (F). Reprinted with permission from Li et al., 2021 160 . Copyright 2021 American Chemical Society…”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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“…Such techniques also necessitate highly specialized knowledge for operation, whereas widespread deployment of portable technologies would ideally be usable by nonexperts. In recent years, there has been a trend toward the development of simple "point-and-shoot" systems with automated data analysis to provide the user with simple real-time results (34,35).…”

Section: Future Prospectsmentioning

confidence: 99%

Enhancing the Performance of Analytical Methods to Combat Doping in Sport

Chouinard

2022

LCGC N. Am.

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Ion mobility–mass spectrometry (IM–MS) has become a cornerstone bioanalytical technique over the last two decades. Major advances have included new technology and software that enabled higher resolving power measurements; however, chemistry-based approaches, such as derivatization reactions, have also shown tremendous promise. This article demonstrates our work using IM–MS to detect anabolic steroids and describes how this technology could one day find its way into the anti-doping world.

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Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Cited by 14 publications

References 39 publications

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Applications of ambient ionization mass spectrometry in 2021: An annual review

Enhancing the Performance of Analytical Methods to Combat Doping in Sport

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