Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner, Stephanie; Reynolds, James C.; Turner, Matthew A.; Heaney, Liam M.

doi:10.1002/ansa.202100067

Cited by 17 publications

(15 citation statements)

References 185 publications

(322 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, a growing variety of scientific disciplines are becoming aware of the potential uses of AMS, particularly in the fields of illness diagnosis, forensics, and environmental. 42…”

Section: Ambient Mass Spectrometry (Ams)mentioning

confidence: 99%

Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview

Kumar

2024

Anal. Methods

View full text Add to dashboard Cite

show abstract

“…As a result, a growing variety of scientific disciplines are becoming aware of the potential uses of AMS, particularly in the fields of illness diagnosis, forensics, and environmental. 42…”

Section: Ambient Mass Spectrometry (Ams)mentioning

confidence: 99%

Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview

Kumar

2024

Anal. Methods

View full text Add to dashboard Cite

show abstract

“…Additional guidelines for evaluation of analytical and safety as well as post-analytical validation put forward by our group can be helpful in this quest. These studies will complement the present report where we suggest PIRL-MS may be an invaluable tool situated to meet the needs of a high speed, sensitive and specific skin cancer diagnostic method, further highlighting the utility of ambient MS in rapid diagnosis.…”

Section: Conclusion and Caveatsmentioning

confidence: 99%

Picosecond Infrared Laser Mass Spectrometry Identifies a Metabolite Array for 10 s Diagnosis of Select Skin Cancer Types: A Proof-of-Concept Feasibility Study

et al. 2022

View full text Add to dashboard Cite

Currently, a large number of skin biopsies are taken for each true skin cancer case detected, creating a need for a rapid, high sensitivity, and specificity skin cancer detection tool to reduce the number of unnecessary biopsies taken from benign tissue. Picosecond infrared laser mass spectrometry (PIRL-MS) using a hand-held sampling probe is reported to detect and classify melanoma, squamous cell carcinoma, and normal skin with average sensitivity and specificity values of 86−95% and 91−98%, respectively (at a 95% confidence level) solely requiring 10 s or less of total data collection and analysis time. Classifications are not adversely affected by specimen's quantity of melanin pigments and are mediated by a number of metabolic lipids, further identified herein as potential biomarkers for skin cancer-type differentiation, 19 of which were sufficient here (as a fully characterized metabolite array) to provide high specificity and sensitivity classification of skin cancer types. In situ detection was demonstrated in an intradermal melanoma mouse model wherein in vivo sampling did not cause significant discomfort. PIRL-MS sampling is further shown to be compatible with downstream gross histopathologic evaluations despite loss of tissue from the immediate laser sampling site(s) and can be configured using selective laser pulses to avoid thermal damage to normal skin. Therefore, PIRL-MS may be employed as a decision-support tool to reduce both the subjectivity of clinical diagnosis and the number of unnecessary biopsies currently required for skin cancer screening.

show abstract

“…This review will delve into the applications and developments of AIMS throughout 2022, continuing from our previous 2020 and 2021 editions 3,4 . Search terms used include ‘ambient ionization’ and individual AIMS technique names using the PubMed database in October and November 2022.…”

Section: Introductionmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

Self Cite

View full text Add to dashboard Cite

The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means of performing rapid analysis of samples in their native state, both in and out of the laboratory. The capacity to eliminate sample preparation and pre‐MS separation techniques, leading to true real‐time analysis, has led to AIMS naturally gaining a broad interest across the scientific community. Since the introduction of the first AIMS techniques in the mid‐2000s, the field has exploded with dozens of novel ion sources, an array of intriguing applications, and an evident growing interest across diverse areas of study. As the field continues to surge forward each year, ambient ionization techniques are increasingly becoming commonplace in laboratories around the world. This annual review provides an overview of AIMS techniques and applications throughout 2022, with a specific focus on some of the major fields of research, including forensic science, disease diagnostics, pharmaceuticals and food sciences. New techniques and methods are introduced, demonstrating the unwavering drive of the analytical community to further advance this exciting field and push the boundaries of what analytical chemistry can achieve.

show abstract

Applications of ambient ionization mass spectrometry in 2021: An annual review

Cited by 17 publications

References 185 publications

Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview

Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview

Picosecond Infrared Laser Mass Spectrometry Identifies a Metabolite Array for 10 s Diagnosis of Select Skin Cancer Types: A Proof-of-Concept Feasibility Study

Applications of ambient ionization mass spectrometry in 2022: An annual review

Contact Info

Product

Resources

About