Plasma arginine vasopressin concentration in horses undergoing surgery for colic

Abstract

Compared with healthy horses, horses with colic had higher preanesthesia plasma AVP concentrations that did not increase further in response to anesthesia and surgery. Exogenous AVP is associated with decreased splanchnic perfusion in a variety of animal species and, therefore, could be detrimental to horses with colic. Thus, it may be inappropriate to use exogenous AVP in support of blood pressure in anesthetized horses with colic. Further studies are warranted to define appropriate indications for the use of AVP in horses with colic.

Serial plasma vasopressin concentration in healthy and hospitalised neonatal foals

“…Previous studies evaluating the effects of storage of plasma AVP samples at ‐20°C reported loss of plasma AVP activity of up to 50% during the first 3 weeks of storage, followed by 5% loss over a 6 month period . Interestingly, leaving plasma AVP samples at room temperature for up to 1.5 h or repeated freezing and thawing did not alter the recovery of AVP . Apronitin did not prevent the loss of activity during freezing , nor did it influence plasma activity of AVP when blood samples were stored in ice water for up to 105 min , indicating that the supplementation of apronitin is not necessary for sample integrity.…”

“…Interestingly, leaving plasma AVP samples at room temperature for up to 1.5 h or repeated freezing and thawing did not alter the recovery of AVP . Apronitin did not prevent the loss of activity during freezing , nor did it influence plasma activity of AVP when blood samples were stored in ice water for up to 105 min , indicating that the supplementation of apronitin is not necessary for sample integrity. To the authors’ knowledge, no studies have evaluated the effects of freezing at ‐80°C on plasma AVP concentrations.…”

Clinical, hematologic, and electrolyte changes with 0.9% sodium chloride or acetated fluids in endurance horses

“…The decrease in PCV and TPP are expected responses to fluid therapy and the restoration of blood volume. The change in TPP has been used as an assessment of the change in the size of the plasma volume assuming no change in the overall amount of protein . The decrease in heart rate is also consistent with this volume expansion.…”

A Comparison of Hypertonic (7.2%) and Isotonic (0.9%) Saline for Fluid Resuscitation in Horses: A Randomized, Double‐blinded, Clinical Trial

“…Changes in hemoglobin concentration have been used to estimate changes in plasma volume and appear to be inversely related, although this relationship may be less reliable in horses . The change in TPP has been used as an assessment of the change in the size of the plasma volume assuming no change in the overall amount of protein . Based on this assumption, the plasma volume may have expanded as much as 29.1 ± 4.0% in the HSS group.…”

“…22,23 The change in TPP has been used as an assessment of the change in the size of the plasma volume assuming no change in the overall amount of protein. [24][25][26] Based on this assumption, the plasma volume may have expanded as much as 29.1 ± 4.0% in the HSS group. A similar calculation for the ISS group revealed a change of only 12.0 ± 14.6% which was significantly smaller (P < .0001).…”