Clinical, hematologic, and electrolyte changes with 0.9% sodium chloride or acetated fluids in endurance horses

Fielding, C. Langdon; Magdesian, K. Gary; Meier, Chloe A.; Rhodes, Diane M.

doi:10.1111/j.1476-4431.2012.00745.x

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Historically, saline has been the mainstay fluid of choice in human medicine due to the perception that it is the most physiologically appropriate choice. However, this has been questioned due to concerns regarding the effects of increased chloride load from its administration (58)(59)(60).…”

Section: Balanced Polyionic Vs Salinementioning

confidence: 99%

Current Concepts in Fluid Therapy in Horses

Crabtree

Epstein

2021

Front. Vet. Sci.

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Despite the frequent inclusion of fluid therapy in the treatment of many conditions in horses, there are limited studies available to provide evidenced-based, species-specific recommendations. Thus, equine fluid therapy is based on the application of physiology and extrapolation from evidence in other veterinary species and human medicine. The physiologic principles that underly the use of fluids in medicine are, at first glance, straightforward and simple to understand. However, in the past 20 years, multiple studies in human medicine have shown that creating recommendations based on theory in combination with experimental and/or small clinical studies does not consistently result in best practice. As a result, there are ongoing controversies in human medicine over fluid types, volumes, and routes of administration. For example, the use of 0.9% NaCl as the replacement fluid of choice is being questioned, and the theoretical benefits of colloids have not translated to clinical cases and negative effects are greater than predicted. In this review, the current body of equine research in fluid therapy will be reviewed, connections to the controversies in human medicine and other veterinary species will be explored and, where appropriate, recommendations for fluid therapy in the adult horse will be made based on the available evidence. This review is focused on the decisions surrounding developing a fluid plan involving crystalloids, synthetic colloids, and plasma.

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Section: Balanced Polyionic Vs Salinementioning

confidence: 99%

Current Concepts in Fluid Therapy in Horses

Crabtree

Epstein

2021

Front. Vet. Sci.

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“…Die Elektrolyt-, Laktat-sowie Säure-Base- Bei gesunden anästhesierten Pferden mit alleiniger Verabreichung von 10 ml/kg/h RL konnten keine signifikanten Naund Cl-Veränderungen über eine 150-Minuten-Allgemeinanästhesie festgestellt werden (Boscan et al 2007), ebenso nicht, wenn 5 -10 ml/kg/h RL für 150 Minuten mit 2,5 ml/kg/h 6 % HAES für 60 Minuten kombiniert wurden (Wendt-Hornickle et al 2011). Bei Distanzpferden konnte nach 20 L einer intravenös verabreichten ausgewogenen kristalloiden Flüssigkeit mit Acetat als Buffer eine Erhöhung des Na um 0,68 % und des Cl um 2,94 % beobachtet werden (Fielding et al 2012). In unserer Studie konnten wir die bisherigen Ergebnisse bestätigen.…”

Section: Ergebnisseunclassified

“…Bisherige Studien haben die Anwendung von RL mit und ohne HAES verglichen (WendtHornickle et al 2011), 0.9 % NaCl versus einer ausgewogenen kristalloiden Acetat-Lösung-Infusion untersucht (Fielding et al 2012) und Veränderungen nach HAES-Boli (Ohta et al 2013) …”

Section: Introductionunclassified

Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate- and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and Medetomidine

Mayer¹,

Bettschart‐Wolfensberger²,

Junge³

et al. 2014

PHK

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Zusammenfassung: Ziel der Studie war es, den Effekt von zwei Ringer-Laktat-Lösungen (Fresenius ® = RLF, Bichsel ® = RLB) auf Elektrolytund Laktatkonzentration sowie Säure-Basen-Status beim Pferd während einer 6-stündigen Allgemeinanästhesie zu untersuchen. Zehn Pferde wurden mit 10 ml/kg/h RLF oder RLB während der Allgemeinanästhesie infundiert. Natrium (Na), Kalium (K), Chlorid (Cl), ionisiertes Kalzium (iCa), Laktat, pH, pCO 2 und Basenüberschuss (BE) wurden vor und alle 30 Minuten nach Einleitung bestimmt (M30 -M360). Unterschiede zwischen den Gruppen wurden mittels Mann-Whitney-U-Tests analysiert. Statistische Signifikanz wurde bei p < 0,05 festgelegt. Es gab keine signifikanten Unterschiede für Na, K, Cl, pH und BE. Das iCa war bei M150 signifikant höher mit RLF (p = 0,025), war jedoch in beiden Gruppen bereits bei M30 tief und fiel bis M360 weiter ab. Die Laktatkonzentration stieg über die Zeit an und war bei M120 (p = 0,016) und M360 (p = 0,036) signifikant höher mit RLB. Es konnten keine klinisch relevanten Unterschiede nach Verabreichung von RLF oder RLB bei den Elektrolyt-und Laktatkonzentrationen sowie beim Säure-Basen-Status über eine Allgemeinanästhesiezeit von 6 h gezeigt werden.Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate-and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and MedetomidineThe aim of this study was to compare the effect of two Ringer-Lactate solutions (Fresenius ® = RLF, Bichsel ® = RLB) on electrolyte and lactate concentrations as well as acid-base status of horses undergoing 6 h of general anaesthesia. Ten horses were allocated to receive either RLF or RLB at 10 ml/kg/hour during anaesthesia. Na, K, Cl, ionized Ca, lactate, pH, pCO 2 and BE were measured before and every 30 minutes after induction throughout anaesthesia (M30 -M360). Differences between groups were assessed with Mann-Whitney-U-test. Statistical significance was set at p < 0,05. There were no significant differences in Na, K and Cl, pH, pCO 2 and BE. Ionized Ca was significantly higher with RLF at M150 (p = 0,025), but was already low in both groups at M30 and decreased further until M360. Lactate concentrations increased in both groups over time and was significantly higher with RLB at M120 (p = 0,016) and M360 (p = 0,036). There were no clinically significant differences in electrolyte and lactate concentration as well as acid-base-status after administration of either RLF or RLB during six-hour general anaesthesia in horses. Einleitung

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“…When given intravenously, isotonic crystalloid administration has predominantly demonstrated effective volume expansive effects in veterinary studies. The described biochemical changes include reductions in packed cell volume (PCV), total plasma proteins (TP), and haemoglobin content which have been presumed as subsequent to haemodilution (Tollofsrud et al 2001;Fielding et al 2012;Valverde et al 2008;Muir et al 2011;Rose et al 1980). Results of multiple studies involving modest to large infusion volumes have consistently found no changes in serum sodium or calcium.…”

Section: Introductionmentioning

confidence: 99%

“…Results of multiple studies involving modest to large infusion volumes have consistently found no changes in serum sodium or calcium. (Tollofsrud et al 2001;Fielding et al 2012;Valverde et al 2008;Rose et al 1980;Rohrig 2012;Rohrig et al 2014). Changes in potassium have varied between null (Tollofsrud et al 2001;Fielding et al 2012;Rose et al 1980;Rohrig et al 2014) to increased (Valverde et al 2008;Rohrig 2012) with intravenous infusion.…”

Section: Introductionmentioning

confidence: 99%

Pilot study on the effect of subcutaneous administration of lactated Ringer's solution on biochemistry parameters in healthy euvolemic cats.

Smith¹,

Greer²

2016

Veterinary Medicine & Sci

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Subcutaneous fluid administration is a commonly used therapy in veterinary practice. Its safety and efficacy have been demonstrated in human clinical studies, but have only rarely been discussed in the veterinary literature. This prospective observational study was performed to evaluate changes during a 24 h period in serum biochemistries associated with administration of lactated Ringer's solution subcutaneously to healthy cats. Lactated Ringer's solution was administered subcutaneously once to ten healthy, euvolemic cats at a dose of 22 mL kg−1. Blood biochemistry analytes were sampled at baseline and at serial time points for a total of 24 h. Changes in biochemical analytes at each time point were compared to baseline and evaluated for statistical significance. Serum blood urea nitrogen (BUN) was significantly less than baseline at 4, 6, 12, 18, and 24 h post‐infusion. Serum creatinine was significantly less than baseline at 2, 4 and 6 h. Packed cell volume (PCV) was significantly less than baseline at 6, 12, 18, and 24 h. Total plasma proteins were significantly less than baseline at all time points. Serum electrolytes did not change from baseline at any time point. Urine specific gravity was significantly increased from baseline only at 6 h post‐Lactated Ringer's solution (LRS) administration. Subcutaneous administration of lactated Ringer's solution appears to result in haemodilution with minimal change to serum electrolyte concentrations in clinically normal, euvolemic cats.

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Clinical, hematologic, and electrolyte changes with 0.9% sodium chloride or acetated fluids in endurance horses

Cited by 6 publications

References 22 publications

Current Concepts in Fluid Therapy in Horses

Current Concepts in Fluid Therapy in Horses

Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate- and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and Medetomidine

Pilot study on the effect of subcutaneous administration of lactated Ringer's solution on biochemistry parameters in healthy euvolemic cats.

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