Plasma Antioxidant Capacity in Morbidly Obese Patients Before and After Weight Loss

Melissas, John; Malliaraki, Niki; Papadakis, John A.; Taflampas, Panagiotis; Kampa, Marilena; Castanas, Elias

doi:10.1381/096089206776116444

Cited by 47 publications

(29 citation statements)

References 22 publications

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“…In adults, Tsai et al (2009) showed similar findings, a 4% reduction in body weight did not change either plasma or urinary F(2)-isoprostane [51]. Moreover, Melissas et al (2006) did not observe any changes in serum TAC after surgical weight reduction [25].…”

supporting

confidence: 52%

Total antioxidant capacity and oxidative stress after a 10-week dietary intervention program in obese children

et al. 2013

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Dietary and serum total antioxidant capacity (TAC) are considered appropriate tools for investigating the potential healthy effects of dietary antioxidants consumed in mixed diets. The aim was to analyse the impact of a dietary intervention on macronutrient intakes and to evaluate the improvement on oxidative status after weight loss (WL) by 1 measuring dietary and serum TAC, and urinary F2-isoprostane levels as markers of oxidative stress. Forty-four overweight/obese children (mean age 11.5yr) were enrolled to undergo a 10-week WL program. They were dichotomized at the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change, as high (HR) and low responders (LR) after intervention. Subjects were prescribed a fixed full-day meal diet, calculated according to their basal metabolic rate and physical activity levels. A validated foodfrequency questionnaire was used to retrospectively calculate TAC and daily nutrient intake. The HR subjects were able to reduce anthropometric indices and to improve lipid and glucose profile. They also significantly diminished fat intake (p=0.013).Moreover, baseline serum TAC values did significantly predict the reduction in urinary F2 isoprostane [B= -0.236 (-0.393 to -0.078); p=0.014] in the HR group after the WL program. Notably, changes in dietary TAC after the treatment were associated with a decrease in body weight after the 10-week intervention [B=-2.815 (-5.313 to -0.318), p=0.029] in the HR group. The -ΔSerumTAC/ΔDietaryTAC and the -ΔF2Isoprostane/ΔDietaryTAC ratios revealed that the relationships between oxidative markers and antioxidants dietary intake were more favourable in the HR than in the LR group. Conclusion:Our study showed that a 10-week WL program was able to reduce adiposity indices in obese children. Moreover, after the intervention changes in dietary TAC and WL were significantly associated. Our result suggests that specific food with a high TAC content (such as fruits, vegetables and legumes) could be recommended to improve WL.

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confidence: 52%

Total antioxidant capacity and oxidative stress after a 10-week dietary intervention program in obese children

et al. 2013

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“…Melissas and cols. observed that weight loss and decrease in BMI obtained through placing a balloon in the stomach of extremely obese individuals for 6 months, increased the plasma antioxidant capacity (26). Bougoulia and cols.…”

Section: Discussionmentioning

confidence: 97%

The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E

Ramezanipour

Jalali

Sadrzade-Yeganeh

et al. 2014

Arq Bras Endocrinol Metab

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Objective: Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it's relation with vitamins A, E and C intake in 30 obese women. Subjects and methods: General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Results: Glutathione reductase and catalase activities showed a significant increase (P < 0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P = 0.004, r = 0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P = 0.005, r = -0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r = -0.385, r = -0.397, P < 0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. Conclusions: Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy. Arq Bras Endocrinol Metab. 2014;58(7):744-9 Keywords Obesity; enzymic antioxidants; weight reduction RESUMO Objetivo: Nosso objetivo foi avaliar os efeitos da perda de peso sobre as enzimas antioxidantes de eritrócitos, e a relação destas com a ingestão das vitaminas A, E e C. Sujeitos e métodos: Foram coletadas informações gerais e medidas antropométricas, registro alimentar de três dias e amostras de sangue em jejum de 30 mulheres obesas no início do estudo e depois de três meses da intervenção. A perda de peso determinada antes da intervenção foi de 10% do peso. Resultados: As atividades da glutationa redutase e da catalase mostraram aumento significativo (P < 0,01) depois da perda de peso, mas não houve mudanças significativas nas atividades da superóxido dismutase e da glutationa peroxidase. Foi observada uma correlação linear positiva entre a ingestão diária de vitamina C e a enzima superóxido dismutase após a intervenção (P = 0,004, r = 0,507). Houve uma correlação linear negativa entre a ingestão de vitamina E e a atividade da glutationa peroxidase antes da intervenção (P = 0,005, r = -0,5). Foi observada uma correlação negativa entre a ingestão diária de vitamina A e a enzima glutationa redutase antes e depois da intervenção (r = -0,385, r = -0,397, P < 0,05), respectivamente. Não foram observadas correlações significativas entre as vitaminas A, C, E e os níveis e a atividade da catalase. Conclusões: Uma redução de 10% no peso pode ter um papel signifi...

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“…Thus, bilirubin may provide a new marker for the assessment of atherogenic risk as well as a therapeutic target for the modification of atherogenic risk. Indeed, several groups of investigators have demonstrated that weight loss therapy (either by sibutramine or via placement of an intragastric balloon) is associated with a rapid increase in total bilirubin levels and antioxidant capacity 46,47) .…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

Yoshino

Hamasaki

Ishida

et al. 2011

JAT

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Plasma Antioxidant Capacity in Morbidly Obese Patients Before and After Weight Loss

Cited by 47 publications

References 22 publications

Total antioxidant capacity and oxidative stress after a 10-week dietary intervention program in obese children

Total antioxidant capacity and oxidative stress after a 10-week dietary intervention program in obese children

The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

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