Plaque control improves the painful symptoms of oral lichen planus gingival lesions. A short‐term study

Salgado, Daniela S.; Jeremias, Fabiano; Capela, Marisa Veiga; Onofre, Mirian Aparecida; Massucato, Elaine Maria Sgavioli; Orrico, Silvana Regina Perez

doi:10.1111/jop.12093

Cited by 51 publications

(83 citation statements)

References 28 publications

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“…At the end of the oral hygiene protocol, the GCF activity of MMP-1 and MMP-9 in diseased sites was no longer statistically different from healthy control sites in both groups (P < 0.05). 19,20 In spite of the differentiated methodologies, we observed an improvement in periodontal indices, painful symptoms, as well as extension and degree of the gingival lesions in line with that reported in the aforementioned studies, but similarly to others patients did not require any additional corticosteroid medication. Similarly, Guiglia and coworkers combined 0.12% chlorhexidine mouthwashes for 7 days with topical corticosteroid therapy in a protocol that included instructions in the use of a soft-bristle toothbrush, supra-and subgingival scaling.…”

Section: Biochemical Activitysupporting

confidence: 90%

“…15,16 Although a meticulous plaque removal does not bring about complete resolution, a structured control could be effective in improving the oral health-related quality of life and clinically observed gingival lesions. [17][18][19][20] Only one study analysed the clinical effectiveness of powered toothbrushing in motivated OLP patients compared to normal plaque control regimen without any additional advice. [17][18][19][20] Only one study analysed the clinical effectiveness of powered toothbrushing in motivated OLP patients compared to normal plaque control regimen without any additional advice.…”

Section: Introductionmentioning

confidence: 99%

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Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

Bianco

Romano

Maggiora

et al. 2018

Int J Dental Hygiene

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Objectives The aim of this randomized, parallel‐design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients. Methods A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control programme comprising supragingival scaling and polishing, and brush‐specific instructions for a period of 8 weeks. The treatment of interest (test) was the use of a sonic‐powered toothbrush, and the standard treatment (control) was the utilization of a soft‐bristle manual toothbrush for twice‐daily home oral hygiene procedures. Periodontal parameters, patient‐centred outcomes, MMP‐1 and MMP‐9 GCF levels were evaluated at baseline and 8 weeks after starting the programme. Results The plaque control programme resulted in statistically significant reduction in periodontal parameters with consequent improvement in the clinical features, painful symptoms and severity of DG lesions in both groups (all P < 0.001). When a sonic toothbrush was used, there was a more significant decrease in clinical indices, mucosal disease scores and GCF levels of MMP‐1 and MMP‐9. Conclusions This clinical trial reported the effectiveness of a combined protocol based on professional oral hygiene and supervised toothbrushing in OLP patients with DG. The daily use of a sonic toothbrush would seem to perform better in the short term.

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Section: Biochemical Activitysupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

Bianco

Romano

Maggiora

et al. 2018

Int J Dental Hygiene

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“…Nevertheless, the severity of gingival inflammation is positively correlated with the extent and clinical aspect of DG. 13,14 In our study, the ulcerative form of DG was associated with the highest scores for PI and MGI, but there were no statistically significant differences in the SBI scores. The amount of horizontal and vertical bone loss was higher in men compared to women in both groups, which could be related to the presence of associated risk factors for gingival inflammation such as smoking and alcohol intake.…”

Section: Discussioncontrasting

confidence: 50%

Original Research. The Influence of Desquamative Gingivitis on Periodontal Health

Monea

Hantoiu

Stoica

et al. 2017

Journal of Interdisciplinary Medicine

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Background: Desquamative gingivitis (DG) is a non-plaque-induced, blistering and painful condition occurring most frequently on the labial aspect of the attached gingiva of anterior teeth. The incidence of DG is highest around 50 years of age, and usually indicates the presence of oral or systemic diseases. The purpose of our study was to determine the impact of DG on periodontal health by recording the plaque index, gingival index and gingival bleeding index in a group of patients with DG, compared to healthy controls. Materials and methods: Recordings of specific indices were performed in a group of 26 patients with DG and compared with 24 healthy individuals. These were followed by radiographic examinations in order to assess the loss of marginal alveolar bone. Results: The results showed that patients with DG had a statistically significant increase in periodontal indices, with more gingival inflammation and plaque retention compared to the control group (p <0.05). The highest scores for gingival inflammation were recorded in patients with DG, but on radiographic evaluation the difference was related only to gender, men being more affected by alveolar bone loss in both groups (p <0.05). Conclusions: The incidence and severity of gingival inflammation proved to be higher in patients with DG, which calls for better preventive and maintenance treatment protocols in this group of patients. Early diagnosis and initial-phase periodontal treatment are very important in preventing further tissue breakdown.

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“…If the former is the explanation then drugs that block the innate immune response may show efficacy in treating this disease. Curiously, it has been shown that plaque control, one method of reducing infection associated with periodontal disease, simultaneously reduces symptoms of oral lichen planus 55,56 …”

Section: Discussionmentioning

confidence: 99%

Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus

Adami

Yeung

Stucki

et al. 2014

Archives of Oral Biology

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Objective Oral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases. Design Fourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in tissue samples consisting of epithelium, stroma, and immune cells. The mRNA level of twelve of these genes expressed in the epithelium was tested in the three groups. Results Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. Conclusions Because of the large accumulation of T cells in lesions of OLP it has long been thought to be an adaptive immunity malfunction. We provide evidence that there is increased expression of innate immune genes in the epithelium with this illness, suggesting a role for this process in the disease and a possible target for treatment.

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Plaque control improves the painful symptoms of oral lichen planus gingival lesions. A short‐term study

Abstract: It was demonstrated that plaque control was effective in improving the clinical features and painful symptoms of oral lichen planus with gingival involvement.

Cited by 51 publications

References 28 publications

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial

Original Research. The Influence of Desquamative Gingivitis on Periodontal Health

Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus

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