Plants Used as Painkiller in Folk Medicine in Turkey-I Stomacache

Erbay, Meryem Şeyda; Anil, Sezin; Melikoğlu, Gülay

doi:10.12991/mpj.2017.0

Cited by 6 publications

(2 citation statements)

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“…Food and therapeutic uses of N. sativa (black cumin) seeds and its fixed oil have a long history in Indian and Islamic culture. N. sativa (NS) has been traditionally used for treatment of various ailments including asthma, bronchitis, rheumatism, headaches, stomach ache and dysentery in Turkish folk medicine [12,13] . Also, Avicenna in his famous book, Canon of Medicine, pointed out several black cumin benefits, such as fatigue and dispiritedness improvement and energy recovery [14]…”

Section: Introductionmentioning

confidence: 99%

“…N. sativa (NS) has been traditionally used for treatment of various ailments including asthma, bronchitis, rheumatism, headaches, stomach ache and dysentery in Turkish folk medicine. [12,13] Also, Avicenna in his famous book, Canon of Medicine, pointed out several black cumin benefits, such as fatigue and dispiritedness improvement and energy recovery. [14] N. damascena L., known as 'Lady in a mist', has also been used in traditional medicine or condiment since ancient times.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect ofNigella sativaandNigella damascenaFixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test

Helvacıoğlu

Charehsaz

Güzelmeriç

et al. 2021

Chemistry & Biodiversity

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The antioxidant and mutagenic/antimutagenic activities of the fixed oils from Nigella sativa (NSO) and Nigella damascena (NDO) seeds, obtained by cold press‐extraction from the cultivar samples, were comparatively investigated for the first time. The antimutagenicity test was carried out using classical and modified Ames tests. The fatty acid composition of the fixed oils was characterized by gas chromatography–mass spectrometry (GC‐MS) while the quantification of thymoquinone in the fixed oils was determined by UPC2. The main components of the NSO and NDO were found to be linoleic acid, oleic acid, and palmitic acid. The results of the Ames test confirmed the safety of NSO and NDO from the viewpoint of mutagenicity. The results of the three antioxidant test methods were correlated with each other, indicating NDO as having a superior antioxidant activity, when compared to the NSO. Both NSO and NDO exhibited a significant protective effect against the mutagenicity induced by aflatoxin B1 in Salmonella typhimurium TA98 and TA100 strains. When microsomal metabolism was terminated after metabolic activation of the mycotoxin, a significant increase in antimutagenic activity was observed, suggesting that the degradation of aflatoxin B1 epoxides by these oils may be a possible antimutagenic mechanism. It is worthy to note that this is the first study to assess the mutagenicity of NSO and NDO according to the OECD 471 guideline and to investigate antimutagenicity of NDO in comparison to NSO against aflatoxin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect ofNigella sativaandNigella damascenaFixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test

Helvacıoğlu

Charehsaz

Güzelmeriç

et al. 2021

Chemistry & Biodiversity

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Medicinal Plants of Northeast Anatolia

Terzioğlu

Çoşkunçelebi

2021

Biodiversity, Conservation and Sustainability in Asia

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Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models

Jaffal

Abbas

2018

Inflammopharmacol

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Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. In this study, the analgesic effect of A. biebersteinii methanolic flower extract was tested in three pain models, namely: writhing, tail-flick and paw-licking (formalin) tests. A. biebersteinii extract inhibited abdominal cramps produced by acetic acid. The effect of A. biebersteinii was better than that of 70 mg/kg indomethacin. In tail flick, A. biebersteinii extract increased latency at 30 min and was as effective as 100 mg/kg diclofenac sodium. In formalin test, A. biebersteinii extracts decreased paw-licking and flinching response in early and late phases. Atropine blocked the action of A. biebersteinii extract (300 mg/kg) in the late phase of formalin test as well as in writhing and tail-flick tests. GC-MS analysis revealed that ascaridole and iso-ascaridole were the main constituents of A. biebersteinii flower extract. In conclusion, this study shows for the first time that the antinociceptive effect of A. biebersteinii is mediated by the cholinergic receptor.

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Plants Used as Painkiller in Folk Medicine in Turkey-I Stomacache

Cited by 6 publications

References 0 publications

Protective Effect ofNigella sativaandNigella damascenaFixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test

Protective Effect ofNigella sativaandNigella damascenaFixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test

Medicinal Plants of Northeast Anatolia

Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models

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