Plants as pharmaceutical excipients in oral sustained drug delivery systems: A review

Uwah, T. O.; Akpabio, Ekaette; Effiong, D. E.

doi:10.18231/j.joapr.2021.v9.i3.26-38

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Other such hydrocolloids and biopolymers are employed as copolymers, suspenders, or even as matrix-formers [1][2][3][4]. Particularly, as natural polymers, their versatility and safety, desirable properties such as ready availability and positive impact on manufacturing properties makes them preferred [5][6].…”

Section: Introductionmentioning

confidence: 99%

Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet

Akpabio EI,

Effiong DE,

Uwah TO

et al. 2023

GSC Biol. Pharm. Sci.

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Corchorus olitorius gum in the native form has been researched for use in the food and pharmaceutical industry as a viscosity modifier and binder in immediate release oral tablets. This work sought to investigate the gum as matrix former in the sustained release delivery of Ibuprofen. Corchorus gum was cold-extracted from the leafy plant part, dried and solid state characterization carried out. Tablets of ibuprofen were prepared using 20% of the gum as matrix former employing the wet granulation technique. Mechanical properties and the release kinetics, using dissolution studies, of the ibuprofen tablets were investigated. Obtained results were compared with those of tablets made with same concentration of a natural gum (Xanthan) and a synthetic one, Hydroxypropylmethylcellulose (HPMC) respectively. Corchurus gum sustained the release of the drug for up to 8 hours, controlling a constant release at 20% in a sustained release formulation for from half hour to the four and a half hour duration. It also had a better swelling index than Xathan gum and hydroxypropylmethylcellulose (HPMC).Also tablets formulated had good physicomechanical properties that will make the native gum a good choice for use as a sustained release excipient

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Section: Introductionmentioning

confidence: 99%

Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet

Akpabio EI,

Effiong DE,

Uwah TO

et al. 2023

GSC Biol. Pharm. Sci.

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“…The successful development of such a delivery system could potentially improve the therapeutic efficacy and patient compliance in treating IBDs and other colon-associated diseases [6]. This research investigation aims to develop and evaluate novel colon-targeted mesalamine matrix tablets using a combination of pH-sensitive polymers and natural polysaccharides [7]. This tablet may act as a robust system capable of effectively delivering mesalamine to the targeted site of action in the colon by modulating its release for improved therapeutic efficacy in IBD.…”

Section: Introductionmentioning

confidence: 99%

Modulation of mesalamine release from enteric-coated matrix tablets using natural polysaccharides for localized colonic delivery

Sahu,

Choudhury,

Pasa

et al. 2024

JAPR

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Background: Inflammatory bowel diseases (IBD) require effective colon-targeted drug delivery for improved therapeutic efficacy and minimized systemic side effects. Objectives: The objective of this research was to develop and evaluate novel colon-targeted matrix tablet formulations of mesalamine (5-aminosalicylic acid) for the treatment of IBD. Materials and Methods: Mesalamine matrix tablets were prepared by wet granulation technique using pH-sensitive polymers (HPMC K4M) and biodegradable natural polysaccharides (pectin, chitosan, and guar gum). Tablets were characterized for physicochemical properties, drug content, and in vitro drug release. Compatibility studies using FTIR and DSC confirmed no interaction between mesalamine and polymers. The optimized formulations were enteric-coated with Eudragit S100 and ethyl cellulose. Drug release kinetics and stability studies were conducted. Results and Discussion: The uncoated formulations (M3, M6, M7) showed adequate protection against drug release in simulated gastric (0-2 h) and intestinal (2-5 h) fluids. The enteric-coated formulations (ME3, ME6, ME7) exhibited a lag time of around 2 hours and restricted drug release (<5%) in simulated gastric and intestinal fluids up to 5 hours. However, in simulated colonic fluid (pH 6.8) containing 4% rat cecal contents, these formulations showed enhanced drug release (71-83% in 12 h) due to biodegradation of polymeric matrices by colonic enzymes. Drug release kinetics indicated anomalous transport or super case-II transport mechanisms. Stability studies at 40°C/75% RH for 3 months revealed no significant changes. Conclusion: The developed colon-targeted mesalamine matrix tablets demonstrated the potential to protect the drug from release in the upper GIT while facilitating targeted drug delivery to the colon, which could improve therapeutic efficacy and minimize systemic side effects in the treatment of IBD.

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Chitosan and naproxen salts: preparation and characterization

Medeiros

Ferreira

Cavalheiro

2022

J Therm Anal Calorim

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Plants as pharmaceutical excipients in oral sustained drug delivery systems: A review

Cited by 3 publications

References 24 publications

Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet

Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet

Modulation of mesalamine release from enteric-coated matrix tablets using natural polysaccharides for localized colonic delivery

Chitosan and naproxen salts: preparation and characterization

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