Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet

Abstract

Corchorus olitorius gum in the native form has been researched for use in the food and pharmaceutical industry as a viscosity modifier and binder in immediate release oral tablets. This work sought to investigate the gum as matrix former in the sustained release delivery of Ibuprofen. Corchorus gum was cold-extracted from the leafy plant part, dried and solid state characterization carried out. Tablets of ibuprofen were prepared using 20% of the gum as matrix former employing the wet granulation technique. Mechanical properties and the release kinetics, using dissolution studies, of the ibuprofen tablets were investigated. Obtained results were compared with those of tablets made with same concentration of a natural gum (Xanthan) and a synthetic one, Hydroxypropylmethylcellulose (HPMC) respectively. Corchurus gum sustained the release of the drug for up to 8 hours, controlling a constant release at 20% in a sustained release formulation for from half hour to the four and a half hour duration. It also had a better swelling index than Xathan gum and hydroxypropylmethylcellulose (HPMC).Also tablets formulated had good physicomechanical properties that will make the native gum a good choice for use as a sustained release excipient

Potentials of Sterculia tragacantha Lindl seed husk gum as a release modifier in matrix tablet formulation

“…Extracted gum yield was 2.25 %w/w and dried gum powder (Figure 3) was light brown in colour, tasteless, coarse to touch and had a characteristic smell. This yield is similar to that reportedly obtained from the leaves of Corchorus olitorius [16]. Confirmatory tests on the powder were positive for a carbohydrate and gum.…”

“…Organoleptic, confirmatory and pH test: Extracted gum was observed for colour, smell, taste and texture and confirmatory tests, Ruthenium and Molisch tests were done as described in a previous study [16]. Gum pH was also measured using a pH meter in a 1 %w/v solution; test was in triplicate.…”

“…Table 1 presents the formula utilized in the formulation of theophylline granules via wet granulation using previously established methods [16]. Granule flow attributes were evaluated as with the polymer powders.…”

“…Matrix tablets of 400 mg target weight were compressed with a single punch tableting machine (Cadmach, Ahmedabad, India) with an upper punch pressure of 38kN and 15 kN lower punch pressure fitted with a 12.5 mm flat-faced punch. Tablets were allowed to relax for 24 hours before evaluation for weight uniformity, diameter, thickness, hardness, friability using already established methods from previous works [16]. Tablet porosity was calculated using the formula (equation 6)…”