Plantas e constituintes químicos empregados em Odontologia: revisão de estudos etnofarmacológicos e de avaliação da atividade antimicrobiana in vitro em patógenos orais

Vieira, Denise Regina Pontes; Amaral, Flávia Maria Mendonça do; Maciel, Márcia C.G.; Nascimento, Flávia R.F.; Libério, A.S.

doi:10.1590/s1516-05722014000100020

Cited by 12 publications

(16 citation statements)

References 68 publications

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“…It was also observed, in this study, a moderate antifungal potential 28 before species of the genus Candida (CIM=1 mg/ mL) . S. officinalis showed fungistatic profile, with values of CFM, between 1-2 mg/mL, inhibiting the visible growth of yeasts.…”

Section: Resultssupporting

confidence: 80%

“…It was observed that the extract of S. officinalis has antimicrobial activity against species of Streptococcus, considered strong (S. mutans, S. mitis, S. sanguis: CIM=0.25 mg/mL) to moderate (S. salivarius: CIM=0.5mg/mL) S. oralis: CIM=1 mg/mL), according to the classification established by Aligiannis et al 28 . The extract of S. officinalis showed bacteriostatic profile, with inhibition of the growth of the microorganism without causing its death, which can be positive, if considered the imbalance of the oral microbiota produced by antibacterial substances.…”

Section: Resultsmentioning

confidence: 99%

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In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

et al. 2019

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The emergence of multidrug-resistant strains to antibiotics has motivated the search for new substances with antimicrobial activity, especially those derived from medicinal plants. Salvia officinalis L. is a medicinal plant that arouses scientific interest due to being associated with multiple therapeutic effects. The purpose of this study was to evaluate the in vitro antimicrobial potential of S. officinalis L. against pathogens in the oral cavity. The antimicrobial potential of the ethanol extract of leaf of S. officinalis L was evaluated by broth microdilution, with determination of minimum inhibitory concentration (MIC) and Minimum bactericidal/Fungicide concentration (MBC / MFC), against the species Streptococcus mutans, Streptococcus mitis, Streptococcus oralis, Streptococcus salivarius, Streptococcus sanguis, Candida albicans, Candida glabrata, Candida guillermond, Candida krusei and Candida tropicalis. The extract showed moderate antifungal potential before Candida species (MIC = 1 mg/mL). And for the species of Streptococcus, the antimicrobial activity was from moderate to strong whose MIC ranged from 0.25 to 1 mg/mL. In this study, the extract from the leaves of S. officinalis L. presented oral cavity antimicrobial activity against pathogens. These results point to S. officinalis as a possible source of active ingredients in the development of formulations with antimicrobial activity of dental use.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

et al. 2019

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“…Regarding secondary metabolites Palombo et al, Viera et al, Milonova et al, among others, have directly associated plant extracts and fractions antimicrobial activity against oral cavity bacteria with secondary metabolite content, such as phenols, polyphenols, flavonoids, terpenes and alkaloids, among others [28,120,121].…”

Section: Anticariogenic and Antiperiodontal Activitiesmentioning

confidence: 99%

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

et al. 2019

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Berberis goudotii is an endemic Colombian plant found in the paramo ecosystem. It has been used in food preparation and as a medicinal plant for diverse treatments. Additionally, it is used as a mouthwash to strengthen the gums and combat throat irritations and periodontitis. The present research evaluated Berberis goudotii aerial parts extract and fractions antimicrobial activities. Ultrasonic-assisted extraction was used to attain total ethanol-water extract. Solid-liquid fractionation was used to obtain hexane fraction. The residue was dispersed in water and liquid-liquid fractionation was carried-out to acquire dichloromethane, butanol and water fractions. Preliminary phytochemical analysis was performed on total extract and phenol, polyphenol, flavonoid, and proanthocyanidin, while tannin content was quantified. Antimicrobial activity assessment was performed by agar diffusion method using disks and wells employing Ceftazidime as a positive control against Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lactobacillus casei, Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Antimicrobial activity was determined as relative percentage inhibition (RPI), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Phenols (92.5 ± 7.7 mg GA/10 g), polyphenols (87.7 ± 8.1 mg PG/10 g) and tannins (44.1 ± 4.3 mg PG/10 g) were among the highest secondary metabolites observed. Total extract presented an MBC of 1.0 µg/µL against cariogenic bacteria (Streptococcus mutans and Streptococcus sobrinus) and 0.12 µg/µL against bacteria associated with periodontal disease (Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum). Butanol and hexane fractions showed antiperiodontal activity with MBC of 0.12 and 1.0 µg/µL, respectively. In conclusion, Berberis goudotii total extract demonstrated antimicrobial activity against cariogenic and periodontal microorganisms, on the other hand, hexane and butanol fractions displayed antiperiodontal activity.

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“…Nesse ínterim, a seleção das plantas para estudos farmacológicos e toxicológicos é um passo relevante, principalmente no fornecimento da matéria-prima para produção de novos medicamentos eficientes contra microorganismos de interesse em saúde bucal (RATES, 2001;FEJERSKOV;KIDD, 2005;VIEIRA et al, 2014).…”

Section: Introductionunclassified

Mini revisão: BIOATIVOS DE Libidibia ferrea E SUAS AÇÕES EM ODONTOLOGIA

Drozino¹,

Zulin²,

Casagrande³

et al. 2017

Arq Mudi

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Compostos bioativos de plantas são de extrema importância para a produção de novos medicamentos, principalmente quando se trata da medicina complementar. Em tratamentos odontológicos, dores e incômodos são recorrentes, levando o paciente, muitas vezes a interromperem ou pararem o tratamento sem o conhecimento de seu dentista. Dessa forma, bioativos e fitoterápicos, como os de Libidibia ferrea, que apresentam eficiência no tratamento de enfermidades bucais e ação contra microrganismos patógenos, são uma alternativa para tratamentos odontológicos mais eficientes. O extrato de L. ferrea favorece o interesse científico pela indústria odontológica e farmacêutica, por apresentar atividades analgésicas, anti-inflamatórias e de ação anti-bacteriana contra patógenos da cavidade bucal. A ineficiência de alguns compostos sintéticos, o alto custo na produção de alopáticos e o interesse da população por tratamentos menos agressivos favorecem a pesquisa científica nesse ramo. Por hora, mesmo com a comprovação da eficiência e da produção de medicamentos baseada em compostos bioativos de L. ferrea, seu uso é um tanto restrito em odontologia, um desafio a ainda ser explorado pela comunidade científica.

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Plantas e constituintes químicos empregados em Odontologia: revisão de estudos etnofarmacológicos e de avaliação da atividade antimicrobiana in vitro em patógenos orais

Cited by 12 publications

References 68 publications

In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

Mini revisão: BIOATIVOS DE Libidibia ferrea E SUAS AÇÕES EM ODONTOLOGIA

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