Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens

Finkina, Ekaterina I.; Melnikova, Daria N.; Bogdanov, Ivan V.; Ovchinnikova, Tatiana V.

doi:10.2174/0929867323666161026154111

Cited by 52 publications

(49 citation statements)

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“…Interestingly, the major alder pollen allergen Aln g 1, but not Bet v 1 from birch pollen, was identified as a major respiratory sensitizer in 18 cases. Both pollen major allergens from the botanic species Fagales belong to the PR‐10 family, a protein family with innate immune function in plants . They are able to ignite Th2 immune responses in humans and animals by their ligand‐binding capacity .…”

Section: Discussionmentioning

confidence: 99%

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Einhorn

Hofstetter

Brandt

et al. 2018

Allergy

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BackgroundCompanion animals are also affected by IgE‐mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles.MethodsCustom‐designed allergen microarray was produced on the basis of the ImmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity. The included horse patients were diagnosed for eczema due to insect bite hypersensitivity, chronic coughing, recurrent airway obstruction and urticaria or were clinically asymptomatic.ResultsHorses showed individual IgE‐binding patterns irrespective of their health status, indicating sensitization. In contrast to European and Japanese human sensitization patterns, frequently recognized allergens were Aln g 1 from alder and Cyn d 1 from Bermuda grass, likely due to specific respiratory exposure around paddocks and near the ground. The most prevalent allergen for 72.5% of the tested horses (37/51) was the 2S‐albumin Fag e 2 from buckwheat, which recently gained importance not only in human but also in horse diet.ConclusionIn line with the One Health concept, covering human health, animal health and environmental health, allergen microarrays provide novel information on the allergen sensitization patterns of the companion animals around us, which may form a basis for allergen‐specific preventive and therapeutic concepts.

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Section: Discussionmentioning

confidence: 99%

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Einhorn

Hofstetter

Brandt

et al. 2018

Allergy

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“…Many aeroallergens belong to specific protein families that can directly interact with microbial constituents, e.g., members of the lipocalin protein family are known to bind to microbial iron-chelators named siderophores [77], thereby directly affecting their virulence and the microbial composition at the mucosal site. Similarly, pollen allergens such as from birch belonging to the pathogenesis-related protein 10 family are components of the innate immunity system in plants and can exert antimicrobial activities at the mucosal linings [83], by capturing iron [84]. As such, allergens may not only trigger asthmatic events by IgE cross-linking, but may alter the microbial composition at mucosal sites per se.…”

Section: Ii) Influence Of Pollen Allergens and Pollutants On Airwaymentioning

confidence: 99%

Dysbiosis of the gut and lung microbiome has a role in asthma

et al. 2020

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Worldwide 300 million children and adults are affected by asthma. The development of asthma is influenced by environmental and other exogenous factors synergizing with genetic predisposition, and shaping the lung microbiome especially during birth and in very early life. The healthy lung microbial composition is characterized by a prevalence of bacteria belonging to the phyla Bacteroidetes, Actinobacteria, and Firmicutes. However, viral respiratory infections are associated with an abundance of Proteobacteria with genera Haemophilus and Moraxella in young children and adult asthmatics. This dysbiosis supports the activation of inflammatory pathways and contributes to bronchoconstriction and bronchial hyperresponsiveness. Exogenous factors can affect the natural lung microbiota composition positively (farming environment) or negatively (allergens, air pollutants). It is evident that also gut microbiota dysbiosis has a high influence on asthma pathogenesis. Antibiotics, antiulcer medications, and other drugs severely impair gut as well as lung microbiota. Resulting dysbiosis and reduced microbial diversity dysregulate the bidirectional crosstalk across the gut-lung axis, resulting in hypersensitivity and hyperreactivity to respiratory and food allergens. Efforts are undertaken to reconstitute the microbiota and immune balance by probiotics and engineered bacteria, but results from human studies do not yet support their efficacy in asthma prevention or treatment. Overall, dysbiosis of gut and lung seem to be critical causes of the increased emergence of asthma.

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“…Exploration of genes associated with pathogen resistance in plants using diverse approaches is a major research focus. The evolution of resistance genes has been observed in numerous model plants [30,31,32]. Expression profiling of genes related to FW resistance in cucumber has not previously been reported.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals ethylene-mediated defense responses to Fusarium oxysporum f. sp. cucumerinum infection in Cucumis sativus

Dong

Wang

Xian

et al. 2020

Preprint

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Background: Fusarium wilt, caused by Fusarium oxysporum f. sp. cucumerinum (Foc), is a severe disease affecting cucumber (Cucumis sativus L.) production worldwide, but mechanisms underlying Fusarium wilt resistance in cucumber remain unknown. To better understanding of the defense mechanisms elicited in response to Foc inoculation, RNA sequencing-based transcriptomic profiling of responses of the Fusarium wilt-resistant cucumber line ‘Rijiecheng’ at 0, 24, 48, 96, and 192 hours after Foc inoculation was performed.Results: We identified 4116 genes that were differentially expressed between 0 hour and other time points after inoculation. All ethylene-related and pathogenesis-related genes from the differentially expressed genes were filtered out. Real-time PCR analysis showed that ethylene-related genes were induced in response to Foc infection. Importantly, after Foc infection and exogenous application of ethephon, a donor of ethylene, the ethylene-related genes were highly expressed. In response to exogenous ethephon treatment in conjunction with Foc inoculation, the infection resistance of cucumber seedlings was enhanced and endogenous ethylene biosynthesis increased dramatically. Conclusion: Collectively, ethylene signaling pathways play a positive role in regulating the defense response of cucumber to Foc infection. The results provide insight into the cucumber Fusarium wilt defense mechanisms and provide valuable information for breeding new cucumber cultivars with enhanced Fusarium wilt tolerance.

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Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens

Cited by 52 publications

References 0 publications

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Dysbiosis of the gut and lung microbiome has a role in asthma

Transcriptome analysis reveals ethylene-mediated defense responses to Fusarium oxysporum f. sp. cucumerinum infection in Cucumis sativus

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